Radiation Oncology Journal

  • 제34권3호
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  • Pages.193-201
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  • 2016
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  • 2234-1900(pISSN)
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  • 2234-3156(eISSN)
대한방사선종양학회 (The Korean Society for Radiation Oncology)
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Radiation therapy for gastric mucosa-associated lymphoid tissue lymphoma: dose-volumetric analysis and its clinical implications

  • Lim, Hyeon Woo (Proton Therapy Center, Research Institute and Hospital, National Cancer Center) ;
  • Kim, Tae Hyun (Proton Therapy Center, Research Institute and Hospital, National Cancer Center) ;
  • Choi, Il Ju (Center for Gastric Cancer, Research Institute and Hospital, National Cancer Center) ;
  • Kim, Chan Gyoo (Center for Gastric Cancer, Research Institute and Hospital, National Cancer Center) ;
  • Lee, Jong Yeul (Center for Gastric Cancer, Research Institute and Hospital, National Cancer Center) ;
  • Cho, Soo Jeong (Center for Gastric Cancer, Research Institute and Hospital, National Cancer Center) ;
  • Eom, Hyeon Seok (Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center) ;
  • Moon, Sung Ho (Proton Therapy Center, Research Institute and Hospital, National Cancer Center) ;
  • Kim, Dae Yong (Proton Therapy Center, Research Institute and Hospital, National Cancer Center)
  • 투고 : 2016.07.10
  • 심사 : 2016.08.04
  • 발행 : 2016.09.30
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초록

Purpose: To assess the clinical outcomes of radiotherapy (RT) using two-dimensional (2D) and three-dimensional conformal RT (3D-CRT) for patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma to evaluate the effectiveness of involved field RT with moderate-dose and to evaluate the benefit of 3D-CRT comparing with 2D-RT. Materials and Methods: Between July 2003 and March 2015, 33 patients with stage IE and IIE gastric MALT lymphoma received RT were analyzed. Of 33 patients, 17 patients (51.5%) were Helicobacter pylori (HP) negative and 16 patients (48.5%) were HP positive but refractory to HP eradication (HPE). The 2D-RT (n = 14) and 3D-CRT (n = 19) were performed and total dose was 30.6 Gy/17 fractions. Of 11 patients who RT planning data were available, dose-volumetric parameters between 2D-RT and 3D-CRT plans was compared. Results: All patients reached complete remission (CR) eventually and median time to CR was 3 months (range, 1 to 15 months). No local relapse occurred and one patient died with second primary malignancy. Tumor response, survival, and toxicity were not significantly different between 2D-RT and 3D-CRT (p > 0.05, each). In analysis for dose-volumetric parameters, $D_{max}$ and CI for PTV were significantly lower in 3D-CRT plans than 2D-RT plans (p < 0.05, each) and $D_{mean}$ and V15 for right kidney and $D_{mean}$ for left kidney were significantly lower in 3D-CRT than 2D-RT (p < 0.05, each). Conclusion: Our data suggested that involved field RT with moderate-dose for gastric MALT lymphoma could be promising and 3D-CRT could be considered to improve the target coverage and reduce radiation dose to the both kidneys.

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참고문헌

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