Radiation Oncology Journal

  • 제34권3호
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  • Pages.177-185
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  • 2016
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  • 2234-1900(pISSN)
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  • 2234-3156(eISSN)
대한방사선종양학회 (The Korean Society for Radiation Oncology)
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Preoperative chemoradiotherapy followed by local excision in clinical T2N0 rectal cancer

  • Shin, Young Seob (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Yoon, Yong sik (Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lim, Seok-Byung (Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Yu, Chang Sik (Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Tae Won (Department of Medical Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Chang, Heung Moon (Department of Medical Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, Jin-hong (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ahn, Seung Do (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Sang-Wook (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Choi, Eun Kyung (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Jin Cheon (Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Jong Hoon (Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine)
  • 투고 : 2016.07.12
  • 심사 : 2016.08.30
  • 발행 : 2016.09.30
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초록

Purpose: To investigate whether preoperative chemoradiotherapy (PCRT) followed by local excision (LE) is feasible approach in clinical T2N0 rectal cancer patients. Materials and Methods: Patients who received PCRT and LE because of clinical T2 rectal cancer within 7 cm from anal verge between January 2006 and June 2014 were retrospectively analyzed. LE was performed in case of a good clinical response after PCRT. Patients' characteristics, treatment record, tumor recurrence, and treatment-related complications were reviewed at a median follow-up of 49 months. Results: All patients received transanal excision or transanal minimally invasive surgery. Of 34 patients, 19 patients (55.9%) presented pathologic complete response (pCR). The 3-year local recurrence-free survival and disease free-survival were 100.0% and 97.1%, respectively. There was no recurrence among the patients with pCR. Except for 1 case of grade 4 enterovesical fistula, all other late complications were mild and self-limiting. Conclusion: PCRT followed by an LE might be feasible as an alternative to total mesorectal excision in good responders with clinical T2N0 distal rectal cancer.

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참고문헌

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피인용 문헌

  1. Clinical utility of pretreatment prediction of chemoradiotherapy response in rectal cancer: a review vol.8, pp.1, 2016, https://doi.org/10.1007/s13167-017-0082-x
  2. Predictive value of carcinoembryonic antigen and carbohydrate antigen 19-9 related to downstaging to stage 0–I after neoadjuvant chemoradiotherapy in locally advanced rectal cancer vol.10, pp.None, 2016, https://doi.org/10.2147/cmar.s166417
  3. Oncologic Outcome and Morbidity in the Elderly Rectal Cancer Patients After Preoperative Chemoradiotherapy and Total Mesorectal Excision: A Multi-institutional and Case-matched Control Study vol.269, pp.1, 2016, https://doi.org/10.1097/sla.0000000000002443
  4. Predictive value of changes in the level of carbohydrate antigen 19‐9 in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy vol.22, pp.12, 2020, https://doi.org/10.1111/codi.15355