디지털융복합연구 (Journal of Digital Convergence)

  • 제14권5호
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  • Pages.459-471
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  • 2016
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  • 2713-6434(pISSN)
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  • 2713-6442(eISSN)
한국디지털정책학회 (The Society of Digital Policy and Management)
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백삼, 홍삼, 흑삼 추출물의 생리활성 비교 연구

The comparative study on physiological activity of White ginseng, Red ginseng and Black ginseng extract

  • 장아영 (중부대학교 한방건강관리학과) ;
  • 승윤철 (중부대학교 한방건강관리학과) ;
  • 지중구 (중부대학교 한방건강관리학과)
  • 투고 : 2016.04.08
  • 심사 : 2016.05.20
  • 발행 : 2016.05.28
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초록

이 연구에서는 백삼(WG), 홍삼(RG) 흑삼(BG) 추출물의 효능차이를 비교하고자 항산화 및 항염 활성을 측정하였다. 세포독성 측정 결과 WG, RG, BG 모두 95% 이상의 세포 생존율을 나타내었고, 페놀함량, DPPH, ABTS 라디컬 소거능, ROS 생성량을 조사한 결과 WG와 RG에 비해 BG가 높은 항산화 활성을 보였다. NO생성 저해활성은 RG가, $PGE_2$생성 저해활성은 WG가 높았다. 염증성 사이토카인 생성량 감소에 미치는 영향을 측정한 결과, IL-$1{\beta}$ 생성량의 경우, WG와 RG가, IL-6 생성량의 경우 BG가 가장 큰 것으로 확인하였다. TNF-${\alpha}$ 생성량은 WG, RG, BG 모두 대조군과 비교하여 차이가 없었다. 이상의 분석 자료가 건강기능 식품과 기능성 화장품 원료 개발 등 전 임상단계의 기초적 자료로 가치가 있을 것으로 판단된다.

This study presents a comparative study for differences in efficacy and ingredient of white ginseng(WG), red ginseng(RG), and black ginseng(BG) using anti-oxidative activity test and anti-inflammatory activity test. In the results of cytotoxicity test for WG, RG, and BG, the survival rate of all cells was more than 95%. In the total polyphenol analysis, DPPH, ABTS radical scavenging test, and ROS production test, BG showed higher anti-oxidant activity than WG and RG. RG and WG showed higher inhibition activity of NO production and $PGE_2$ production, respectively. As results of the test for the effect on reduction of inflammatory cytokine production, WG and RG were effective on reduction of IL-$1{\beta}$ production, and BG was effective on reduction of IL-6. In the case of TNF-${\alpha}$ production, there was no difference among samples. This study could be useful basic data for the development of functional food and the fabrication of safe cosmetic.

키워드

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