Radiation Oncology Journal

  • 제34권1호
  • /
  • Pages.59-63
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  • 2016
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  • 2234-1900(pISSN)
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  • 2234-3156(eISSN)
대한방사선종양학회 (The Korean Society for Radiation Oncology)
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Local radiotherapy for palliation in multiple myeloma patients with symptomatic bone lesions

  • Lee, Jeong Won (Department of Radiation Oncology, Kyungpook National University Hospital, Kyungpook National University School of Medicine) ;
  • Lee, Jeong Eun (Department of Radiation Oncology, Kyungpook National University Hospital, Kyungpook National University School of Medicine)
  • 투고 : 2015.09.14
  • 심사 : 2016.01.05
  • 발행 : 2016.03.31
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초록

Purpose: To evaluate the clinical outcomes of symptomatic bone lesions in patients with multiple myeloma (MM) who received local radiotherapy (LRT). Materials and Methods: Fifty-one patients with 87 symptomatic bone lesions treated via LRT were analyzed. LRT was delivered at a median total dose of 21 Gy (range, 12 to 40 Gy) in a median of 7 fractions (range, 4 to 20 fractions). The clinical outcomes of LRT and the factors affecting treatment response were assessed. Results: After a median follow-up time of 66.7 weeks, symptom relief was achieved for 85 of 87 lesions (97.7%). The median time to symptom relief was 7 days from the start of LRT (range, 1 to 67 days). The duration of in-field failure-free survival ranged from 1.1 to 450.9 weeks (median, 66.7 weeks). The radiation dose or use of previous and concurrent chemotherapy was not significantly associated with in-field failure for LRT (p = 0.354, 0.758, and 0.758, respectively). Conclusion: Symptomatic bone lesions in patients with MM can be successfully treated with LRT. A higher radiation dose or the use of concurrent chemotherapy may not influence the in-field disease control. A relatively low radiation dose could achieve remission of symptoms in patients with MM.

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참고문헌

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