DOI QR코드

DOI QR Code

Is height a risk factor for colorectal adenoma?

  • Pyo, Jeung Hui (Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Hong, Sung Noh (Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Min, Byung-Hoon (Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Chang, Dong Kyung (Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Son, Hee Jung (Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Rhee, Poong-Lyul (Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Jae J. (Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Young-Ho (Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2014.10.16
  • Accepted : 2015.01.08
  • Published : 2016.07.01

Abstract

Background/Aims: Although it is generally known that the risk for all types of cancer increases with adult height, combined and for several common site-specific cancers (including colon and rectal), evidence is limited for adenomas, which are precursors to colorectal cancer. We evaluated the association between height and risk of colorectal adenoma at various stages of the adenoma-carcinoma pathway. Methods: We conducted a retrospective study using data from patients who had undergone a complete colonoscopy as part of a health examination at the Health Promotion Center of Samsung Medical Center between October 13, 2009 and December 31, 2011. A total of 1,347 male subjects were included in our study. Multivariate logistic regression analysis was used to evaluate the association between height and colorectal adenoma. Results: Each 5-cm increase in height was associated with 1.6% and 5.3% higher risks of advanced colorectal adenoma and high-risk colorectal adenoma, respectively, but associations were not significant after adjusting for age, body mass index, metabolic syndrome, alcohol intake, smoking, family history of colorectal cancer, and regular aspirin use (p = 0.840 and p = 0.472, respectively). Conclusions: No clear association was found between colorectal adenoma risk and height. Unlike other site-specific tumors reported to have a consistent relationship with height, the association between colorectal tumor and height remains controversial.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea

References

  1. Gunnell D, Okasha M, Smith GD, Oliver SE, Sandhu J, Holly JM. Height, leg length, and cancer risk: a systematic review. Epidemiol Rev 2001;23:313-342. https://doi.org/10.1093/oxfordjournals.epirev.a000809
  2. Batty GD, Shipley MJ, Langenberg C, Marmot MG, Davey Smith G. Adult height in relation to mortality from 14 cancer sites in men in London (UK): evidence from the original Whitehall study. Ann Oncol 2006;17:157-166. https://doi.org/10.1093/annonc/mdj018
  3. Pischon T, Lahmann PH, Boeing H, et al. Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst 2006;98:920-931. https://doi.org/10.1093/jnci/djj246
  4. Levine JS, Ahnen DJ. Clinical practice: adenomatous polyps of the colon. N Engl J Med 2006;355:2551-2557. https://doi.org/10.1056/NEJMcp063038
  5. Winawer SJ, Zauber AG, Ho MN, et al. Prevention of colorectal cancer by colonoscopic polypectomy: the National Polyp Study Workgroup. N Engl J Med 1993;329:1977-1981. https://doi.org/10.1056/NEJM199312303292701
  6. Walter RB, Brasky TM, Buckley SA, Potter JD, White E. Height as an explanatory factor for sex differences in human cancer. J Natl Cancer Inst 2013;105:860-868. https://doi.org/10.1093/jnci/djt102
  7. Hamilton SR, Aaltone LA. Tumors of the colon and rectum. In: Aaltone LA, Hamilton SR; World Health Organization; International Agency for Research on Cancer, eds. Pathology and Genetics of Tumors of the Digestive System. Lyon: IARC Press, 2000:103-143.
  8. Song YM, Smith GD, Sung J. Adult height and cause-specific mortality: a large prospective study of South Korean men. Am J Epidemiol 2003;158:479-485. https://doi.org/10.1093/aje/kwg173
  9. Caan BJ, Coates AO, Slattery ML, Potter JD, Quesenberry CP Jr, Edwards SM. Body size and the risk of colon cancer in a large case-control study. Int J Obes Relat Metab Disord 1998;22:178-184. https://doi.org/10.1038/sj.ijo.0800561
  10. Dales LG, Friedman GD, Ury HK, Grossman S, Williams SR. A case-control study of relationships of diet and other traits to colorectal cancer in American blacks. Am J Epidemiol 1979;109:132-144. https://doi.org/10.1093/oxfordjournals.aje.a112668
  11. Dietz AT, Newcomb PA, Marcus PM, Storer BE. The association of body size and large bowel cancer risk in Wisconsin (United States) women. Cancer Causes Control 1995;6:30-36. https://doi.org/10.1007/BF00051678
  12. Freudenheim JL, Graham S, Marshall JR, Haughey BP, Wilkinson G. A case-control study of diet and rectal cancer in western New York. Am J Epidemiol 1990;131:612-624. https://doi.org/10.1093/oxfordjournals.aje.a115545
  13. Higginson J. Etiological factors in gastrointestinal cancer in man. J Natl Cancer Inst 1966;37:527-545.
  14. Jain M, Cook GM, Davis FG, Grace MG, Howe GR, Miller AB. A case-control study of diet and colo-rectal cancer. Int J Cancer 1980;26:757-768. https://doi.org/10.1002/ijc.2910260609
  15. La Vecchia C, Negri E, Parazzini F, et al. Height and cancer risk in a network of case-control studies from northern Italy. Int J Cancer 1990;45:275-279. https://doi.org/10.1002/ijc.2910450212
  16. Le Marchand L, Wilkens LR, Kolonel LN, Hankin JH, Lyu LC. Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of colorectal cancer. Cancer Res 1997;57:4787-4794.
  17. Manousos O, Souglakos J, Bosetti C, et al. IGF-I and IGFII in relation to colorectal cancer. Int J Cancer 1999;83:15-17. https://doi.org/10.1002/(SICI)1097-0215(19990924)83:1<15::AID-IJC4>3.0.CO;2-Y
  18. Papadimitriou C, Day N, Tzonou A, Gerovassilis F, Manousos O, Trichopoulos D. Biosocial correlates of colorectal cancer in Greece. Int J Epidemiol 1984;13:155-159. https://doi.org/10.1093/ije/13.2.155
  19. Peters RK, Garabrant DH, Yu MC, Mack TM. A case-control study of occupational and dietary factors in colorectal cancer in young men by subsite. Cancer Res 1989;49:5459-5468.
  20. Russo A, Franceschi S, La Vecchia C, et al. Body size and colorectal-cancer risk. Int J Cancer 1998;78:161-165. https://doi.org/10.1002/(SICI)1097-0215(19981005)78:2<161::AID-IJC7>3.0.CO;2-X
  21. Weiss NS, Daling JR, Chow WH. Incidence of cancer of the large bowel in women in relation to reproductive and hormonal factors. J Natl Cancer Inst 1981;67:57-60.
  22. Howe GR, Aronson KJ, Benito E, et al. The relationship between dietary fat intake and risk of colorectal cancer: evidence from the combined analysis of 13 case-control studies. Cancer Causes Control 1997;8:215-228. https://doi.org/10.1023/A:1018476414781
  23. Ahrens EH Jr, Blankenhorn DH, Hirsch J. Measurement of the human intestinal length in vivo and some causes of variation. Gastroenterology 1956;31:274-284.
  24. Ituarte EA, Petrini J, Hershman JM. Acromegaly and colon cancer. Ann Intern Med 1984;101:627-628. https://doi.org/10.7326/0003-4819-101-5-627
  25. Sadahiro S, Ohmura T, Yamada Y, Saito T, Taki Y. Analysis of length and surface area of each segment of the large intestine according to age, sex and physique. Surg Radiol Anat 1992;14:251-257. https://doi.org/10.1007/BF01794949
  26. Hounnou G, Destrieux C, Desme J, Bertrand P, Velut S. Anatomical study of the length of the human intestine. Surg Radiol Anat 2002;24:290-294. https://doi.org/10.1007/s00276-002-0057-y
  27. Giovannucci E. Insulin and colon cancer. Cancer Causes Control 1995;6:164-179. https://doi.org/10.1007/BF00052777
  28. Moore LL, Bradlee ML, Singer MR, et al. BMI and waist circumference as predictors of lifetime colon cancer risk in Framingham Study adults. Int J Obes Relat Metab Disord 2004;28:559-567. https://doi.org/10.1038/sj.ijo.0802606

Cited by

  1. Prevalence and risk factors of colorectal cancer in Asia vol.17, pp.3, 2019, https://doi.org/10.5217/ir.2019.00021