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Predictive factors of mortality within 30 days in patients with nonvariceal upper gastrointestinal bleeding

  • Lee, Yoo Jin (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Min, Bo Ram (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Kim, Eun Soo (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Park, Kyung Sik (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Cho, Kwang Bum (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Jang, Byoung Kuk (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Chung, Woo Jin (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Hwang, Jae Seok (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Jeon, Seong Woo (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University School of Medicine)
  • Received : 2014.04.03
  • Accepted : 2014.11.13
  • Published : 2016.01.01

Abstract

Background/Aims: Nonvariceal upper gastrointestinal bleeding (NVUGIB) is a common medical emergency that can be life threatening. This study evaluated predictive factors of 30-day mortality in patients with this condition. Methods: A prospective observational study was conducted at a single hospital between April 2010 and November 2012, and 336 patients with symptoms and signs of gastrointestinal bleeding were consecutively enrolled. Clinical characteristics and endoscopic findings were reviewed to identify potential factors associated with 30-day mortality. Results: Overall, 184 patients were included in the study (men, 79.3%; mean age, 59.81 years), and 16 patients died within 30 days (8.7%). Multivariate analyses revealed that comorbidity of diabetes mellitus (DM) or metastatic malignancy, age ${\geq}65$ years, and hypotension (systolic pressure < 90 mmHg) during hospitalization were significant predictive factors of 30-day mortality. Conclusions: Comorbidity of DM or metastatic malignancy, age ${\geq}65$ years, and hemodynamic instability during hospitalization were predictors of 30-day mortality in patients with NVUGIB. These results will help guide the management of patients with this condition.

Keywords

References

  1. Marmo R, Koch M, Cipolletta L, et al. Predictive factors of mortality from nonvariceal upper gastrointestinal hemorrhage: a multicenter study. Am J Gastroenterol 2008;103:1639-1647. https://doi.org/10.1111/j.1572-0241.2008.01865.x
  2. Holster IL, Kuipers EJ. Management of acute nonvariceal upper gastrointestinal bleeding: current policies and future perspectives. World J Gastroenterol 2012;18:1202-1207. https://doi.org/10.3748/wjg.v18.i11.1202
  3. Gonzalez-Gonzalez JA, Vazquez-Elizondo G, Garcia-Compean D, et al. Predictors of in-hospital mortality in patients with non-variceal upper gastrointestinal bleeding. Rev Esp Enferm Dig 2011;103:196-203. https://doi.org/10.4321/S1130-01082011000400005
  4. Barkun AN, Bardou M, Kuipers EJ, et al. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med 2010;152:101-113. https://doi.org/10.7326/0003-4819-152-2-201001190-00009
  5. Saltzman JR, Tabak YP, Hyett BH, Sun X, Travis AC, Johannes RS. A simple risk score accurately predicts in-hospital mortality, length of stay, and cost in acute upper GI bleeding. Gastrointest Endosc 2011;74:1215-1224. https://doi.org/10.1016/j.gie.2011.06.024
  6. Rockall TA, Logan RF, Devlin HB, Northfield TC. Risk assessment after acute upper gastrointestinal haemorrhage. Gut 1996;38:316-321. https://doi.org/10.1136/gut.38.3.316
  7. Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for upper-gastrointestinal haemorrhage. Lancet 2000;356:1318-1321. https://doi.org/10.1016/S0140-6736(00)02816-6
  8. Romagnuolo J, Barkun AN, Enns R, Armstrong D, Gregor J. Simple clinical predictors may obviate urgent endoscopy in selected patients with nonvariceal upper gastrointestinal tract bleeding. Arch Intern Med 2007;167:265-270. https://doi.org/10.1001/archinte.167.3.265
  9. Wiley TE, McCarthy M, Breidi L, McCarthy M, Layden TJ. Impact of alcohol on the histological and clinical progression of hepatitis C infection. Hepatology 1998;28:805-809. https://doi.org/10.1002/hep.510280330
  10. Marin-Gabriel JC, Solis-Herruzo JA. Noninvasive assessment of liver fibrosis: serum markers and transient elastography (FibroScan). Rev Esp Enferm Dig 2009;101:787-799.
  11. The 86th Congress of the Japanese Society of Legal Medicine. Okayama, Japan. April 17-19, 2002. Abstracts. Nihon Hoigaku Zasshi 2002;56:1-203.
  12. Jeon SW, Jung MK, Cho CM, et al. Predictors of immediate bleeding during endoscopic submucosal dissection in gastric lesions. Surg Endosc 2009;23:1974-1979. https://doi.org/10.1007/s00464-008-9988-7
  13. Forrest JA, Finlayson ND, Shearman DJ. Endoscopy in gastrointestinal bleeding. Lancet 1974;2:394-397.
  14. Xu HW, Wang JH, Tsai MS, et al. The effects of cefazolin on cirrhotic patients with acute variceal hemorrhage after endoscopic interventions. Surg Endosc 2011;25:2911-2918. https://doi.org/10.1007/s00464-011-1642-0
  15. Mungan Z. An observational European study on clinical outcomes associated with current management strategies for non-variceal upper gastrointestinal bleeding (ENERGIB-Turkey). Turk J Gastroenterol 2012;23:463-477. https://doi.org/10.4318/tjg.2012.0402
  16. Barkun A, Sabbah S, Enns R, et al. The Canadian Registry on Nonvariceal Upper Gastrointestinal Bleeding and Endoscopy (RUGBE): endoscopic hemostasis and proton pump inhibition are associated with improved outcomes in a real-life setting. Am J Gastroenterol 2004;99:1238-1246. https://doi.org/10.1111/j.1572-0241.2004.30272.x
  17. Crooks C, Card T, West J. Reductions in 28-day mortality following hospital admission for upper gastrointestinal hemorrhage. Gastroenterology 2011;141:62-70. https://doi.org/10.1053/j.gastro.2011.03.048
  18. Manguso F, Riccio E, Bennato R, et al. In-hospital mortality in non-variceal upper gastrointestinal bleeding Forrest 1 patients. Scand J Gastroenterol 2008;43:1432-1441. https://doi.org/10.1080/00365520802307989
  19. Leontiadis GI, Molloy-Bland M, Moayyedi P, Howden CW. Effect of comorbidity on mortality in patients with peptic ulcer bleeding: systematic review and meta-analysis. Am J Gastroenterol 2013;108:331-345. https://doi.org/10.1038/ajg.2012.451
  20. Nahon S, Hagege H, Latrive JP, et al. Epidemiological and prognostic factors involved in upper gastrointestinal bleeding: results of a French prospective multicenter study. Endoscopy 2012;44:998-1008. https://doi.org/10.1055/s-0032-1310006
  21. Sung JJ, Tsoi KK, Ma TK, Yung MY, Lau JY, Chiu PW. Causes of mortality in patients with peptic ulcer bleeding: a prospective cohort study of 10,428 cases. Am J Gastroenterol 2010;105:84-89. https://doi.org/10.1038/ajg.2009.507
  22. Chiu PW, Ng EK, Cheung FK, et al. Predicting mortality in patients with bleeding peptic ulcers after therapeutic endoscopy. Clin Gastroenterol Hepatol 2009;7:311-316. https://doi.org/10.1016/j.cgh.2008.08.044
  23. Ishihara M, Kagawa E, Inoue I, et al. Impact of admission hyperglycemia and diabetes mellitus on short- and longterm mortality after acute myocardial infarction in the coronary intervention era. Am J Cardiol 2007;99:1674-1679. https://doi.org/10.1016/j.amjcard.2007.01.044
  24. Cox AJ, Hugenschmidt CE, Wang PT, et al. Usefulness of biventricular volume as a predictor of mortality in patients with diabetes mellitus (from the Diabetes Heart Study). Am J Cardiol 2013;111:1152-1158. https://doi.org/10.1016/j.amjcard.2012.12.044
  25. Thomsen RW, Riis A, Christensen S, Norgaard M, Sorensen HT. Diabetes and 30-day mortality from peptic ulcer bleeding and perforation: a Danish population-based cohort study. Diabetes Care 2006;29:805-810. https://doi.org/10.2337/diacare.29.04.06.dc05-1748
  26. Murata A, Matsuda S, Kuwabara K, Ichimiya Y, Fujino Y, Kubo T. The influence of diabetes mellitus on short-term outcomes of patients with bleeding peptic ulcers. Yonsei Med J 2012;53:701-707. https://doi.org/10.3349/ymj.2012.53.4.701
  27. Larche J, Azoulay E, Fieux F, et al. Improved survival of critically ill cancer patients with septic shock. Intensive Care Med 2003;29:1688-1695. https://doi.org/10.1007/s00134-003-1957-y
  28. Gisbert JP, Khorrami S, Carballo F, Calvet X, Gene E, Dominguez-Munoz E. Meta-analysis: Helicobacter pylori eradication therapy vs. antisecretory non-eradication therapy for the prevention of recurrent bleeding from peptic ulcer. Aliment Pharmacol Ther 2004;19:617-629. https://doi.org/10.1111/j.1365-2036.2004.01898.x

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