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STAT6 and PARP Family Members in the Development of T Cell-dependent Allergic Inflammation

  • Purna Krishnamurthy (Department of Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine) ;
  • Mark H. Kaplan (Department of Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine)
  • Received : 2016.05.04
  • Accepted : 2016.07.20
  • Published : 2016.08.31
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Abstract

Allergic inflammation requires the orchestration of altered gene expression in the target tissue and in the infiltrating immune cells. The transcription factor STAT6 is critical in activating cytokine gene expression and cytokine signaling both in the immune cells and in target tissue cells including airway epithelia, keratinocytes and esophageal epithelial cells. STAT6 is activated by the cytokines IL-4 and IL-13 to mediate the pathogenesis of allergic disorders such as asthma, atopic dermatitis, food allergy and eosinophilic esophagitis (EoE). In this review, we summarize the role of STAT6 in allergic diseases, its interaction with the co-factor PARP14 and the molecular mechanisms by which STAT6 and PARP14 regulate gene transcription.

Keywords

Acknowledgement

The authors dedicate this article to the memory of Shreevrat Goenka who began the PARP14/ARTD8/Coast6 field a decade ago.

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