Journal of Cardiovascular Imaging

Korean Society of Echocardiography (한국심초음파학회)
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Clinical Utility of Echocardiography for the Diagnosis and Prognosis in Children with Bronchopulmonary Dsyplasia

  • Choi, Young Earl (Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School) ;
  • Cho, Hwa Jin (Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School) ;
  • Song, Eun Song (Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School) ;
  • Jeong, In Seok (Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hospital, Chonnam National University Medical School) ;
  • Yoon, Namsik (The Heart Center of Chonnam National University Hospital, Chonnam National University Medical School and The Research Institute of Medical Sciences of Chonnam National University) ;
  • Choi, Young Youn (Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School) ;
  • Ma, Jae Sook (Department of Pediatrics, KS Hospital) ;
  • Cho, Young Kuk (Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School)
  • Received : 2016.03.19
  • Accepted : 2016.11.30
  • Published : 2016.12.27
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Abstract

Background: Bronchopulmonary dysplasia (BPD) may result in chronic pulmonary artery hypertension and right ventricular (RV) dysfunction. Various echocardiographic assessments of RV dysfunction have been used to determine whether echocardiographic measurements of premature infants with BPD could provide sensitive measures of RV function that correlates with BPD severity. Methods: Twenty-eight control subjects without BPD (non BPD group), 28 patients with mild BPD, 11 patients with moderate BPD, and six patients with severe BPD underwent echocardiograms with standard measurement such as ejection fraction by M-mode, tricuspid regurgitation pressure gradient, myocardial performance index (MPI) derived from pulse Doppler, and tissue Doppler imaging (TDI) measurements. BPD severity was classified by the NICHD/NHLBI/ORD workshop rating scale. Twenty-eight control subjects without BPD (non BPD group), 28 patients with mild BPD, 11 patients with moderate BPD, and six patients with severe BPD underwent echocardiograms with standard measurement such as ejection fraction by M-mode, tricuspid regurgitation pressure gradient, myocardial performance index (MPI) derived from pulse Doppler, and TDI measurements. BPD severity was classified by the NICHD/NHLBI/ORD workshop rating scale. Results: None of the standard echocardiographic findings was significantly different between the control group and BPD groups. However, mean septal TDI-MPI of the severe BPD group ($0.68{\pm}0.06$) was significantly (p < 0.01) higher than that of the non-BPD ($0.58{\pm}0.10$) or the mild BPD group ($0.59{\pm}0.12$). In addition, mean RV TDI-MPI of the severe BPD group ($0.71{\pm}0.13$) was significantly (p < 0.05) higher than that of the non-BPD group ($0.56{\pm}0.08$) or the mild BPD group ($0.60{\pm}0.125$). Linear regression showed a good correlation between the severity of BPD and RV TDI-MPI (p = 0.01, R = 0.30) or septal TDI-MPI (p = 0.04, R = 0.24). Conclusion: Echocardiographic evaluation of RV function based on an assessment of RV TDI-MPI can provide RV dysfunction parameter in premature infants with BPD.

Keywords

Acknowledgement

Supported by : Chonnam National University Hospital Biomedical Research Institute, National Research Foundation of Korea (NRF)

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