YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Antigenicity of Purified Bee Venom Gel from Honeybee (Apis mellifera L.) in Guinea Pigs

기니픽에서 정제봉독겔의 광독성 평가

  • Han, Sang Mi (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) ;
  • Hong, In Phyo (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) ;
  • Woo, Soon Ok (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) ;
  • Kim, Se Gun (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) ;
  • Jang, Hye Ri (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) ;
  • Park, Kyun Kyu (Catholic University of Daegu School of Medicine)
  • 한상미 (국립농업과학원 농업생물부) ;
  • 홍인표 (국립농업과학원 농업생물부) ;
  • 우순옥 (국립농업과학원 농업생물부) ;
  • 김세건 (국립농업과학원 농업생물부) ;
  • 장혜리 (국립농업과학원 농업생물부) ;
  • 박관규 (대구가톨릭대학교 의과대학)
  • Received : 2015.12.14
  • Accepted : 2016.02.25
  • Published : 2016.04.30
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Abstract

This study was performed to examine the skin phototoxicity of purified bee venom (Apis mellifera L.) collected using bee venom collector. To confirm whether the gel containing purified bee venom (BV gel) causes photototoxicity when used for the skin medicinal products, phototoxicity testing was conducted using guinea pig models. The BV gel (0.1 ml/site) was administered transdermally to guinea pigs. 8-MOP was used to introduce positive control response. After administration, the guinea pigs were irradiated with UVA ($15J/cm^2$) with doses based on standard phototoxicity study guidelines. In the weight measurement and clinical observation, BV gel groups didn't show any significant changes compared with control group. BV gel groups did not show any symptoms such as erythema and edema formation of skin. This study demonstrated that BV gel has promising potential external treatment for topical uses that do not induce significant levels of skin phototoxicity.

Keywords

References

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