Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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The Relationship between Angiotensin-II Type 1 Receptor Gene Polymorphism and Repolarization Parameters after a First Anterior Acute Myocardial Infarction

  • Ozturk, Onder (Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital) ;
  • Ozturk, Unal (Department of Public Health and Neurology, Dicle University Medical Faculty) ;
  • Nergiz, Sebnem (Department of Microbiology, Dicle University Medical Faculty) ;
  • Karahan, M. Zulkif (Department of Cardiology, Diyarbakir Gazi Yasargil Education and Research Hospital)
  • Received : 2015.12.17
  • Accepted : 2016.06.13
  • Published : 2016.11.30
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Abstract

Background and Objectives: Genetic influence on T-wave peak to End (Tpe) time in patients with a first anterior acute myocardial infarction (AMI) is uncertain. A polymorphism in the angiotensin-II type 1 receptor (AT1R) gene was discovered recently. The polymorphism consists of an A or C variant, given three different possible genotypes: AA, AC, CC. The purpose of this study was to determine the effects of polymorphism of the AT1R gene polymorphism on Tpe after a first anterior AMI. Subjects and Methods: The subjects were 142 patients (110 men, 32 women, $58{\pm}13$ years) with a first anterior AMI; ten patients were excluded from this study. Based on the polymorphism of the AT1R gene, they were classified into two groups: Group 1 (AA genotype) of 91 patients and group 2 (AC and CC genotype) of 41 patients. A 12-lead resting ECG was recorded at admission to the coronary care unit in patients with anterior AMI and were manually measured with a ruler. QTc, QTd, QTcd, Tpe, Tpe/QT parameters were measured. Results: There was no significant difference in the baseline characteristics of patients (p>0.05). We found significant reduction in QTc, QTd, QTcd, Tpe, Tpe/QT indices Group 1 (AA genotype) (mean $66{\pm}28ms$) than group 2 (AC and CC genotype) (mean $95{\pm}34ms$) (p<0.05). Conclusion: In patients with a first anterior AMI, AT1R gene polymorphisms may influence on repolarization parameters. Although further studies are required.

Keywords

References

  1. Laragh JH. Renin-angiotensin-aldosterone system for blood pressure and electrolyte homeostasis and its involvement in hypertension, in congestive heart failure and in associated cardiovascular damage (myocardial infarction and stroke). J Hum Hypertens 1995;9:385-90.
  2. Aoki S, Mukae S, Itoh S, et al. The genetic factor in acute myocardial infarction with hypertension. Jpn Circ J 2001;65:621-6. https://doi.org/10.1253/jcj.65.621
  3. De Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International Union of Pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000;52:415-72.
  4. Araujo MA, Menezes BS, Lourenço C, Cordeiro ER, Gatti RR, Goulart LR. The A1166C polymorphism of the angiotensin II type-1 receptor in acute myocardial infarction. Arq Bras Cardiol 2004;83:409-13.
  5. Ozturk O, Ozturk U, Bilici A. The effect of angiotensin II type-1 receptor gene polymorphisms on doppler blood flow parameters of carotid and brachial arteries in patients with myocardial infarction. Echocardiography 2006;23:536-41. https://doi.org/10.1111/j.1540-8175.2006.00258.x
  6. Jeron A, Hengstenberg C, Engel S, et al. The D-allele of the ACE polymorphism is related to increased QT dispersion in 609 patients after myocardial infarction. Eur Heart J 2001;22:663-8. https://doi.org/10.1053/euhj.2000.2297
  7. Porthan K, Marjamaa A, Viitasalo M, et al. Relationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parameters. Heart Rhythm 2010;7:898-903. https://doi.org/10.1016/j.hrthm.2010.03.002
  8. Anvari A, Turel Z, Schmidt A, et al. Angiotensin converting enzymeand angiotensin II receptor 1polymorphism in coronary disease and malignant ventricular arrhythmias. Cardiovasc Res 1999;43:879-83. https://doi.org/10.1016/S0008-6363(99)00143-1
  9. Hamon M, Amant C, Bauters C, et al. Association of angiotensin converting enzyme and angiotensin II type 1 receptor genotypes with left ventricular function and mass in patients with angiographically normal coronary arteries. Heart 1997;77:502-5. https://doi.org/10.1136/hrt.77.6.502
  10. Miller SA, Dykes DD, Polesky HF. Simple salting out procedure for extraction DNA from human nucleoted cells. Nucleic Acids Res 1988;16:1215-9. https://doi.org/10.1093/nar/16.3.1215
  11. Malik M, Batchvarov VN. Measurement, interpretation and clinical potential of QT dispersion. J Am Coll Cardiol 2000;36:1749-66. https://doi.org/10.1016/S0735-1097(00)00962-1
  12. Lin TH, Chiu HC, Su HM, et al. D-allele of ACE polymorphism is associated with increased magnitude of QT dispersion prolongation in elderly Chinese: 4-year follow-up study. Circ J 2007;71:39-45. https://doi.org/10.1253/circj.71.39
  13. Jeunemaitre X, Ledru F, Battaglia S, et al. Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE study. Hum Genet 1997;99:66-73.
  14. Eslami V, Safi M, Taherkhani M, Adibi A, Movahed MR. Evaluation of QT, QT dispersion, and T-wave peak to end time changes after primary percutaneous coronaryintervention in patients presenting with acute T-elevation myocardial infarction. J Invasive Cardiol 2013;25:232-4.
  15. Oikarinen L, Nieminen MS, Viitasalo M, et al. Relation of QT interval and QT dispersion to echocardiographic left ventricular hypertrophy and geometric pattern in hypertensive patients: The LIFE study The Losartan Intervention For Endpoint Reduction. J Hypertens 2001;19:1883-91. https://doi.org/10.1097/00004872-200110000-00025
  16. Day CP, McComb JM, Campbell RW. QT dispersion: an indication of arrhythmia risk in patients with long QT intervals. Br Heart J 1990;63:342-4. https://doi.org/10.1136/hrt.63.6.342
  17. Endoh Y, Kasanuki H, Ohnishi S, Uno M.Unsuitability of corrected QT dispersion as a marker for ventricular arrhythmias and cardiac sudden death after acute myocardial infarction. Jpn Circ J 1999;63:467-70. https://doi.org/10.1253/jcj.63.467
  18. Fujimoto S, Uemura S, Tomoda Y, et al. Effects of exercise training on the heart rate variability and QT dispersion of patients with acute myocardial infarction. Jpn Circ J 1999;63:577-82. https://doi.org/10.1253/jcj.63.577
  19. Takezako T, Zhang B, Serikawa T, Fan P, Nomoto J, Saku K. The D allele of the angiotensin-converting enzyme gene and reperfusioninduced ventricular arrhythmias in patients with acute myocardial infarction. Jpn Circ J 2001;65:603-9. https://doi.org/10.1253/jcj.65.603
  20. Gubaev KI, Nasibullin TR, Zakirova AN, Mustafina OE. Association of polymorphic markers I/D of gene ACE and A1166C of gene AT2R1 with ischemic chronic heart failure in the Russian and Tatar populations of Bashkortostan Republic. Genetika 2006;42:1712-7.
  21. Jin Y, Kuznetsova T, Thijs L, et al. Association of left ventricular mass with the AGTR1 A1166C polymorphism. Am J Hypertens 2012;25:472-8. https://doi.org/10.1038/ajh.2011.244
  22. De Sutter J, Tavernier R, Van De, et al. QT dispersion is not related to infarct size or inducibility in patients with coronary artery disease and life threatening ventricular arrhythmias. Heart 1999;81:533-8. https://doi.org/10.1136/hrt.81.5.533
  23. Blanco RR, Austin H, Vest RN, et al. Angiotensin receptor type 1 single nucleotide polymorphism 1166A/C is associated with malignant arrhythmias and altered circulating miR-155 levels in patients with chronic heart failure. J Card Fail 2012;18:717-23. https://doi.org/10.1016/j.cardfail.2012.06.531
  24. Miller JA, Thai K, Scholey JW. Angiotensin II type 1 receptor gene polymorphism predicts response to losartan and angiotensin II. Kidney Int 1999;56:2173-80. https://doi.org/10.1046/j.1523-1755.1999.00770.x
  25. Spargias KS, Lindsay SJ, Hall AS, Cowan JC, Ball SG.Ramipril reduces QT dispersion in patients with acute myocardial infarction and heart failure. Am J Cardiol 1999;83:969-71. https://doi.org/10.1016/S0002-9149(98)01049-2
  26. Karpanou EA, Vyssoulis GP, Psichogios A, et al. Regression of left ventricular hypertrophy results in improvement of QT dispersion in patients with hypertension. Am Heart J 1998;136:765-8. https://doi.org/10.1016/S0002-8703(98)70119-X