Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
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Toxicity and safety classification of 4 animal medicines - Focusing on venoms from bee, snake, blister beetle and scolopendrid -

일부 동물성 한약재의 독성과 안전성등급화 - 봉독, 사독, 반묘와 오공을 중심으로 -

  • Park, Yeongchul (GLP Center, Catholic University of Daegu) ;
  • Lee, Sundong (Dept. of Preventive Korean Medicine, School of Korean Medicine, Sangji University)
  • 박영철 (대구가톨릭대학교 GLP센터) ;
  • 이선동 (상지대학교 한의과대학 예방의학교실)
  • Received : 2016.03.23
  • Accepted : 2016.04.22
  • Published : 2016.04.30
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Abstract

Objectives : About 13% of the medicines used by traditional korean medicines(TKM), are called animal medicines and are derived from non-herbal sources such as animals and insects. However, the clinical use of these preparations from animal medicines is often based on tradition and belief, rather than on evidence of toxicity and efficacy. As a result, animal medicines containing toxin have caused serious problems from injecting patients with venom. Here, various venoms frequently used as TKM were reviewed in terms of their instinct toxity and tried to estimate their safety classification. Methods : The estimation of safety classification was based on human equivalent dose(HED)-based MOS (margin of safety) and clinical dose applied for patients. Results and Conclusions : Except that of snake venom due to no clinical dose, they were evaluated as class 3 for bee venom, class 4 for cantharidin, toxin from blister beetle, and class 1 for venom from scolopendrid. In conclusion, animal medicines showed a wide range of safety classification from class 1 to class 4. This wide range is estimated to result from extremely limited applications of each venom for patients because of their strong toxicity. However, it should be cautious for application in clinics since animal medicines can produce anaphylactic reactions particularly after veinous administration even with a tiny amount of venom.

Keywords

References

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