Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Initial Report for the Radiation Effects Research Foundation F1 Mail Survey

  • Milder, CM (Department of Epidemiology, Radiation Effects Research Foundation) ;
  • Sakata, R (Department of Epidemiology, Radiation Effects Research Foundation) ;
  • Sugiyama, H (Department of Epidemiology, Radiation Effects Research Foundation) ;
  • Sadakane, A (Department of Epidemiology, Radiation Effects Research Foundation) ;
  • Utada, M (Department of Epidemiology, Radiation Effects Research Foundation) ;
  • Cordova, KA (Department of Statistics, Radiation Effects Research Foundation) ;
  • Hida, A (Department of Clinical Studies, Radiation Effects Research Foundation) ;
  • Ohishi, W (Department of Clinical Studies, Radiation Effects Research Foundation) ;
  • Ozasa, K (Department of Epidemiology, Radiation Effects Research Foundation) ;
  • Grant, EJ (Department of Epidemiology, Radiation Effects Research Foundation)
  • Published : 2016.04.11
Download PDF
⟨ Previous Next ⟩

Abstract

To study the full health effects of parental radiation exposure on the children of the atomic bomb survivors, the Radiation Effects Research Foundation developed a cohort of 76,814 children born to atomic bomb survivors (F1 generation) to assess cancer incidence and mortality from common adult diseases. In analyzing radiation-associated health information, it is important to be able to adjust for sociodemographic and lifestyle variations that may affect health. In order to gain this and other background information on the F1 cohort and to determine willingness to participate in a related clinical study, the F1 Mail Survey Questionnaire was designed with questions corresponding to relevant health, sociodemographic, and lifestyle indicators. Between the years 2000 and 2006, the survey was sent to a subset of the F1 Mortality Cohort. A total of 16,183 surveys were completed and returned: 10,980 surveys from Hiroshima residents and 5,203 from Nagasaki residents. The response rate was 65.6%, varying somewhat across parental exposure category, city, gender, and year of birth. Differences in health and lifestyle were noted in several variables on comparison across city and gender. No major differences in health, lifestyle, sociodemographics, or disease were seen across parental exposure categories, though statistically significant tests for heterogeneity and linear trend revealed some possible changes with dose. The data described herein provide a foundation for studies in the future.

Keywords

References

  1. Abouzeid Ali HE, Barber RC, Dubrova YE (2012). The effects of maternal irradiation during adulthood on mutation induction and transgenerational instability in mice. Mutat Res, 732, 21-5. https://doi.org/10.1016/j.mrfmmm.2012.01.003
  2. Barber R, Plumb MA, Boulton E, et al (2002). Elevated mutation rates in the germ line of first- and second-generation offspring of irradiated male mice. Proc Natl Acad Sci USA, 99, 6877-82. https://doi.org/10.1073/pnas.102015399
  3. Barber RC, Hardwick RJ, Shanks ME, et al (2009). The effects of in utero irradiation on mutation induction and transgenerational instability in mice. Mutat Res, 664, 6-12. https://doi.org/10.1016/j.mrfmmm.2009.01.011
  4. Barber RC, Hickenbotham P, Hatch T, et al (2006). Radiationinduced transgenerational alterations in genome stability and DNA damage. Oncogene, 25, 7336-42. https://doi.org/10.1038/sj.onc.1209723
  5. Bernis C, Reher DS (2007). Environmental contexts of menopause in Spain: Comparative results from recent research. Menopause, 14, 777-87. https://doi.org/10.1097/gme.0b013e31803020ff
  6. Chitturi S, Farrell GC, Hashimoto E, et al (2007). Non-alcoholic fatty liver disease in the Asia- Pacific region: Definitions and overview of proposed guidelines. J Gastroen Hepatol, 22, 778-87. https://doi.org/10.1111/j.1440-1746.2007.05001.x
  7. Cullings HM, Fujita S, Funamoto S, et al (2006). Dose estimation for atomic bomb survivor studies: Its evolution and present status. Radiat Res, 166, 219-54. https://doi.org/10.1667/RR3546.1
  8. DSS Research (2014). Calculators: Researcher's toolkit. https://www.dssresearch.com/KnowledgeCenter/toolkitcalculators/statisticalpowercalculators.aspx (accessed October 2014)
  9. Fujiwara S, Suyama A, Cologne JB, et al (2008). Prevalence of adult-onset multifactorial disease among offspring of atomic bomb survivors. Radiat Res, 170, 451-7. https://doi.org/10.1667/RR1392.1
  10. Grant EJ, Furukawa K, Sakata R, et al (2015). Risk of death among children of atomic bomb survivors after 62 years of follow-up: A cohort study. Lancet Oncol, 16, 1316-23. https://doi.org/10.1016/S1470-2045(15)00209-0
  11. Hata J, Ninomiya T, Hirakawa Y, et al (2013). Secular trends in cardiovascular disease and its risk factors in Japanese: Half-century data from the Hisayama Study (1961-2009). Circulation, 128, 1198-205.
  12. Hatano Y, Matsumoto M, Inoue K, et al (2013). Rurality and participation in mass preventive health services: A nationwide descriptive study. Hiroshima J Med Sci, 62, 43-8.
  13. Hayashi M, Iwanaga T, Mitoku K, et al (1999). Getting a high response rate of sexual behavior survey among the general population in Japan: Three different methods of survey on sexual behavior. J Epidemiol, 9, 107-13. https://doi.org/10.2188/jea.9.107
  14. Izumi S, Koyama K, Soda M, et al (2003). Cancer incidence in children and young adults did not increase relative to parental exposure to atomic bombs. Brit J Cancer, 89, 1709-13. https://doi.org/10.1038/sj.bjc.6601322
  15. Johnson TP, Shavitt S, Holbrook AL (2011). Survey response styles across cultures. In 'Cross- cultural research methods in psychology', Eds Matsumoto D., and Van de Vijver F. J. R. Cambridge University Press, New York, NY pp 130-75
  16. Joint US-Japan Working Group (2005). Reassessment of the atomic bomb radiation dosimetry for Hiroshima and Nagasaki. Eds Young RW and Kerr GD. In 'Dosimetry System 2002 DS02 Vol 2', INIS-JP--102, Japan.
  17. Kato H, Schull WJ (1960). Joint JNIH-ABCC Life Span Study of children born of parents exposed to atomic bomb survivors, research plan. No. ABCC TR 4-60
  18. Kato H, Schull WJ, Neel JV (1966). A cohort-type study of survival in the children of parents exposed to atomic bombings. Am J Hum Genet, 18, 339-73.
  19. Kitamura A, Sato S, Naito Y, et al (2001). [Trends in the incidence of cardiovascular diseases and risk factors among urban and rural Japanese males.] Jpn J Public Health, 48, 378-94.
  20. Kodaira M, Ryo H, Kamada N, et al (2010). No evidence of increased mutation rates at microsatellite loci in offspring of A-bomb survivors. Radiat Res, 173, 205-13. https://doi.org/10.1667/RR1991.1
  21. Koyama K, Suyama, A, Grant E J, et al (2002). Health effects study of the children of a-bomb survivors: Mail survey. No. RERF RP 3-02
  22. Little M. P, Wakeford R, Charles MW (1994). An analysis of leukaemia, lymphoma and other malignancies together with certain categories of non-cancer mortality in the first generation offspring (F1) of the Japanese bomb survivors. J Radiol Prot, 14, 203-18. https://doi.org/10.1088/0952-4746/14/3/002
  23. Maruyama M, Ohira T, Imano H, et al (2012). Trends in sudden cardiac death and its risk factors in Japan from 1981 to 2005: The circulatory risk in communities study (CIRCS). BMJ Open, 2, 573.
  24. Matsumoto D, Van de Vijver FJR (2011). Introduction to the methodological issues associated with cross-cultural research. In ' Cross-cultural research methods in psychology ', Eds Matsumoto D. and Van de Vijver F. J. R. Cambridge University Press, New York, NY, 1-14.
  25. Ministry of Health, Labour, and Welfare (2012). Chapter 5: Results by prefecture, the National Health and Nutrition Survey in Japan, 2010. http://www.mhlw.go.jp/bunya/kenkou/eiyou/dl/h22-houkoku-11.pdf (accessed September 2014)
  26. Mohammad K, Sadat Hashemi SM, Farahani FK (2004). Age at natural menopause in Iran. Maturitas, 49, 321-6. https://doi.org/10.1016/j.maturitas.2004.02.006
  27. National Institute of Health and Nutrition (2006). Summary results of the National Health and Nutrition Survey Japan, 2006. Tokyo, Japan.
  28. National Institute of Health and Nutrition (2007). Outline for the results of the National Health and Nutrition Survey Japan, 2007. Tokyo, Japan.
  29. Neel JV, Schull WJ (1956). The effect of exposure to the atomic bombs on pregnancy and termination in Hiroshima and Nagasaki. National Academy of Sciences, National Research Council, Washington 25, D.C.
  30. Neel JV, Kato H, Schull WJ (1974). Mortality in the children of atomic bomb survivors and controls. Genetics, 76, 311-36.
  31. Neel JV, Satoh C, Goriki K, et al (1988). Search for mutations altering protein charge and/or function in children of atomic bomb survivors: Final report. Am J Hum Genet, 42, 663-76.
  32. Nishi N, Sugiyama H, Hsu WL, et al (2008). Differences in mortality and incidence for major sites of cancer by education level in a Japanese population. Ann Epidemiol, 18, 584-91. https://doi.org/10.1016/j.annepidem.2008.02.003
  33. Nishikawa T, Okamura T, Nakayama H, et al (2015). Effects of a public education campaign on the association between knowledge of early stroke symptoms and intention to call an ambulance at stroke onset: The acquisition of stroke knowledge (ASK) study. J Epidemiol, 2016, [Epub ahead of print].
  34. Ohno Y, Tamakoshi A, JACC Study Group (2001). Japan collaborative cohort study for evaluation of cancer risk sponsored by Monbusho (JACC study). J Epidemiol, 11, 144-50. https://doi.org/10.2188/jea.11.144
  35. Otake M, Schull WJ, Neel JV (1990). Congenital malformations, stillbirths, and early mortality among the children of atomic bomb survivors: A reanalysis. Radiat Res, 122, 1-11. https://doi.org/10.2307/3577576
  36. Rinchik EM, Russell LB, Copeland NG, et al. (1986). Molecular genetic analysis of the dilute- short ear (d-se) region of the mouse. Genetics, 112, 321-42.
  37. Saeki H, Iizuka H, Mori Y, et al (2005). Prevalence of atopic dermatitis in Japanese elementary schoolchildren. Brit J Dermatol, 152, 110-14. https://doi.org/10.1111/j.1365-2133.2004.06271.x
  38. Shiraishi K, Shimura T, Taga M, et al (2002). Persistent induction of somatic reversions of the pink-eyed unstable mutation in F1 mice born to fathers irradiated at the spermatozoa stage. Radiat Res, 157, 661-7. https://doi.org/10.1667/0033-7587(2002)157[0661:PIOSRO]2.0.CO;2
  39. StataCorp LP (2013). Obtaining linear combinations of coefficients. In 'Stata user's guide: Release 13.' Stata Press, College Station, TX pp. 286-7
  40. Tamakoshi A, Ozasa K, Fujino Y, et al (2013). Cohort profile of the Japan collaborative cohort study at final follow-up. J Epidemiol, 23, 227-32. https://doi.org/10.2188/jea.JE20120161
  41. Tanaka S, Tanaka S, Iimur, S, et al (2014). Cohort profile: The Japan diabetes complications study: A long-term follow-up of a randomised lifestyle intervention study of type 2 diabetes. Int J Epidemiol, 43, 1054-62. https://doi.org/10.1093/ije/dyt057
  42. Tatsukawa Y, Cologne JB, Hsu WL, et al (2013). Radiation risk of individual multifactorial diseases in offspring of the atomic-bomb survivors: A clinical health study. J Radiol Prot, 33, 281-93. https://doi.org/10.1088/0952-4746/33/2/281
  43. Yaegashi Y, Onoda T, Morioka S, et al (2014). Joint effects of smoking and alcohol drinking on esophageal cancer mortality in Japanese men: findings from the Japan collaborative cohort study. Asian Pac J Cancer Prev, 15, 1023-9. https://doi.org/10.7314/APJCP.2014.15.2.1023
  44. Yoshimoto Y, Nee, JV, Schull WJ, et al (1990). Malignant tumors during the first 2 decades of life in the offspring of atomic bomb survivors. Am J Hum Genet, 46, 1041-52.
  45. Yoshimoto Y, Schull WJ, Kato H, et al (1991). Mortality among the offspring (F1) of atomic bomb survivors, 1946-85. J Radiat Res, 32, 327-51.