Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

The Neutrophil to Lymphocyte Ratio is an Independent Prognostic Factor in Patients with Metastatic Gastric Cancer

  • Musri, Fatma Yalcin (Department of Medical Oncology, Akdeniz University School of Medicine) ;
  • Mutlu, Hasan (Department of Medical Oncology, Akdeniz University School of Medicine) ;
  • Eryilmaz, Melek Karakurt (Department of Medical Oncology, Akdeniz University School of Medicine) ;
  • Salim, Derya Kivrak (Department of Medical Oncology, Akdeniz University School of Medicine) ;
  • Gunduz, Seyda (Department of Medical Oncology, Antalya Training and Research Hospital) ;
  • Coskun, Hasan Senol (Department of Medical Oncology, Akdeniz University School of Medicine)
  • Published : 2016.04.11
Download PDF
⟨ Previous Next ⟩

Abstract

Inflammation can play an important role in cancer progression and the prognostic importance of neutrophil to lymphocyte ratio (NLR), a marker of inflammation, in cancer is a current investigation topic. In the present study, we aimed to determine whether there is a prognostic link between NLR and metastatic gastric cancer (mGC). A total of 143 patients from the Akdeniz University and Antalya Training and Research Hospital database were retrospectively analyzed. The median NLR value was 3.34. The median overall survival (OS) and median progression-free survival (PFS) were 11.6 and 7.9 months, respectively, in patients with NLR<3.34 while these values were 8.3 and 6.2 months respectively in patients with NLR>3.34 (p<0.001 and p=0.011, respectively). Our study showed that increased NLR is an independent prognostic factor associated with short survival in patients with mGC.

Keywords

References

  1. Cho IR, Park JC, Park CH, et al (2014). Pre-treatment neutrophil to lymphocyte ratio as a prognostic marker to predict chemotherapeutic response and survival outcomes in metastatic advanced gastric cancer. Gastric Cancer, 17, 703-10 https://doi.org/10.1007/s10120-013-0330-2
  2. Colotta F, Allavena P, Sica A, et al (2009). Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis, 30, 1073-81. https://doi.org/10.1093/carcin/bgp127
  3. Fogar P, Sperti C, Basso D, et al (2006). Decreased total lymphocytecounts in pancreatic cancer: an index of adverse outcome. Pancreas, 32, 22-8. https://doi.org/10.1097/01.mpa.0000188305.90290.50
  4. Grivennikov SI, Greten FR, Karin M (2010). Immunity, inflammation, and cancer. Cell, 140, 883-99 https://doi.org/10.1016/j.cell.2010.01.025
  5. Gomez D, Farid S, Malik HZ, et al (2008). Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor aftercurative resection for hepatocellular carcinoma. World J Surg, 32, 1757-62 https://doi.org/10.1007/s00268-008-9552-6
  6. Hanahan D, Weinberg RA (2011) .Hallmarks of cancer: the next generation. Cell, 144, 646-74. https://doi.org/10.1016/j.cell.2011.02.013
  7. Herszenyi L, Tulassay Z (2010) . Epidemiology of gastrointestinal and liver tumors. Eur Rev Med Pharmacol Sci, 14, 249-58.
  8. Jung MR, Park YK, Jeong O, et al (2011). Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer. J Surg Oncol, 104, 504-10. https://doi.org/10.1002/jso.21986
  9. Kaya V, Yildirim M, Demirpence O, et al (2013). Prognostic significance of basic laboratory methods in non- small-cell-lung cancer. Asian Pac J Cancer Prev, 14, 5473-6. https://doi.org/10.7314/APJCP.2013.14.9.5473
  10. Kishi Y, Kopetz S, Chun YS, et al (2009). Blood neutrophil-to-lymphocyte ratio predicts survival in patients with colorectal liver metastases treated with systemic chemotherapy. Ann Surg Oncol, 16, 614-22. https://doi.org/10.1245/s10434-008-0267-6
  11. Martinet L, Garrido I, Filleron T, et al (2011). Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer. Cancer Res, 71, 5678-87. https://doi.org/10.1158/0008-5472.CAN-11-0431
  12. Nakano K, Hosoda M, Yamamoto M, et al (2014) . Prognostic significance of pre-treatment neutrophil: lymphocyte ratio in Japanese patients with breast cancer. Anticancer Res, 34, 3819-24.
  13. Ozdemir Y, Akin ML, Sucullu I, et al (2014). Pretreatment neutrophil/lymphocyte ratio as a prognostic aid in colorectal cancer. Asian Pac J Cancer Prev, 15, 2647-50. https://doi.org/10.7314/APJCP.2014.15.6.2647
  14. Roxburgh CS, McMillan DC (2010) . Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol, 6,149-63. https://doi.org/10.2217/fon.09.136
  15. Sarraf KM, Belcher E, Raevsky E ,et al (2009). Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer. J Thorac Cardiovasc Surg, 137, 425-8. https://doi.org/10.1016/j.jtcvs.2008.05.046
  16. Shimada H, Takiguchi N, Kainuma O, et al (2010). High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer. Gastric Cancer, 13, 170-6. https://doi.org/10.1007/s10120-010-0554-3
  17. Smyth MJ, Dunn GP, Schreiber RD (2006). Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity. Adv Immunol, 90, 1-50. https://doi.org/10.1016/S0065-2776(06)90001-7
  18. Templeton AJ, McNamara MG, Seruga B, et al (2014). Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst, 106, 124. https://doi.org/10.1093/jnci/dju124
  19. Vigano A, Bruera E, Jhangri GS, et al (2000). Clinical survival predictors in patients with advanced cancer. Arch Intern Med, 160, 861-8. https://doi.org/10.1001/archinte.160.6.861
  20. Yamanaka T, Matsumoto S, Teramukai S, et al (2007). The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncol, 73, 215-20. https://doi.org/10.1159/000127412

Cited by

  1. Pre-treatment Peripheral Neutrophil-Lymphocyte Ratio as a Prognostic Marker in Gastric Cancer pp.1941-6636, 2018, https://doi.org/10.1007/s12029-018-0144-x
  2. Clinicopathological and prognostic significance of high circulating lymphocyte ratio in patients receiving neoadjuvant chemotherapy for advanced gastric cancer vol.8, pp.1, 2018, https://doi.org/10.1038/s41598-018-24259-5