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Combination therapy of cyclosporine and prednisolone in a dog with systemic lupus erythematosus

  • Kim, Yeon-Hee (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kang, Min-Hee (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Hee-Myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • 투고 : 2015.11.11
  • 심사 : 2016.03.02
  • 발행 : 2016.03.31

초록

An 11-year-old, spayed female poodle presented with fever and shifting lameness. Physical examination revealed hyperthermia ($40.6^{\circ}C$), and proteinuria was detected upon urinalysis. Increased neutrophils (83%) and decreased viscosity were revealed upon synovial fluid analysis. Serum antinuclear antibody was positive at 1 : 80. Based on these findings, the dog was diagnosed with systemic lupus erythematosus. Immunosuppressive therapy was initiated with prednisolone and cyclosporine, and the condition was markedly improved after the treatments. This case report describes the clinical and laboratory findings, imaging characteristics and successful outcomes after prednisolone plus cyclosporine therapy in a canine systemic lupus erythematosus case.

키워드

참고문헌

  1. Bennett D. Immune-based non-erosive inflammatory joint disease of the dog. 1. Canine systemic lupus erythematosus. J Small Anim Pract 1987, 28, 871-889. https://doi.org/10.1111/j.1748-5827.1987.tb01314.x
  2. Berent A, Cerundolo R. Systemic lupus erythematosus. Compend Contin Educ Prac Vet 2005, 7, 7-12.
  3. Bonagura JD, Twedt DC. Kirk's Current Veterinary Therapy XV. pp. 268-274, Elsevier Saunders, St. Louis, 2013.
  4. Clements DN, Gear RN, Tattersall J, Carmichael S, Bennett D. Type I immune-mediated polyarthritis in dogs: 39 cases (1997-2002). J Am Vet Med Assoc 2004, 224, 1323-1327. https://doi.org/10.2460/javma.2004.224.1323
  5. Ettinger SJ, Feldman EC. Textbook of Veterinary Internal Medicine. 7th ed. pp. 783-788, Elsevier Saunders, St. Louis, 2009.
  6. Feutren G. Cyclosporin A: recent developments in the mechanism of action and clinical application. Curr Opin Immunol 1989, 2, 239-245. https://doi.org/10.1016/0952-7915(89)90194-5
  7. Harley L, Langston C. Proteinuria in dogs and cats. Can Vet J 2012, 53, 631-638.
  8. Jones DR. Canine systemic lupus erythematosus: new insights and their implications. J Comp Pathol 1993, 108, 215-228. https://doi.org/10.1016/S0021-9975(08)80286-1
  9. Kim J, Kim K, Ko I, Lee K, Na K, Yang M. A case of systemic lupus erythematosus in a dog. Korean J Vet Clin Med 2000, 17, 443-449.
  10. Kruger RM, Franca RT, Amaral AS, Schossler JEW. Polyarthritis due to systemic lupus erythematosus in a dog. Arq Bras Med Vet Zootec 2013, 65, 393-396. https://doi.org/10.1590/S0102-09352013000200014
  11. Lee CW, Na KJ, Lim JS, Seo JW. Systemic lupus erythematosus in a dog, suspected systemic lupus erythematosus in a dog, and autoimmune thrombocytopenic purpura hemorrhagica in a dog. Korean J Vet Clin Med 1996, 13, 81-86.
  12. Littman MP. Protein-losing nephropathy in small animals. Vet Clin North Am Small Anim Pract 2011, 41, 31-62. https://doi.org/10.1016/j.cvsm.2010.09.006
  13. Manger K, Kalden J, Manger B. Cyclosporin A in the treatment of systemic lupus erythematosus: results of an open clinical study. Br J Rheumatol 1996, 35, 669-675. https://doi.org/10.1093/rheumatology/35.7.669
  14. Tizard IR. Veterinary Immunology. 9th ed. pp. 423-428, Elsevier, St. Louis, 2012.

피인용 문헌

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