생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제23권4호
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  • Pages.193-198
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  • 2016
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  • 1225-8709(pISSN)
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  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
권호 표지

강박장애 및 조현병 환자에서의 정량뇌파 소견과 신경인지기능 간의 연관성

Correlation between Quantitative Electroencephalogram Findings and Neurocognitive Functions in Patients with Obsessive-Compulsive Disorder and Schizophrenia

  • 김서영 (서울대학교병원 정신건강의학과) ;
  • 신정은 (서울대학교병원 정신건강의학과) ;
  • 김민주 (서울대학교병원 정신건강의학과) ;
  • 권준수 (서울대학교병원 정신건강의학과) ;
  • 최수희 (서울대학교병원 정신건강의학과)
  • Kim, Seoyoung (Department of Psychiatry, Seoul National University Hospital) ;
  • Shin, Jung Eun (Department of Psychiatry, Seoul National University Hospital) ;
  • Kim, Min Joo (Department of Psychiatry, Seoul National University Hospital) ;
  • Kwon, Jun Soo (Department of Psychiatry, Seoul National University Hospital) ;
  • Choi, Soo-Hee (Department of Psychiatry, Seoul National University Hospital)
  • 투고 : 2016.08.31
  • 심사 : 2016.10.04
  • 발행 : 2016.11.30
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초록

Objectives Obsessive-compulsive disorder (OCD) and schizophrenia have many common clinical and neurocognitive features. However, not all of them share the same underlying mechanism. The aim of this study was to discover evidences that indicate a pathophysiological mechanism specific to OCD by comparing correlations of quantitative electroencephalography (QEEG) patterns and neurocognitive function in patients with OCD and schizophrenia. Methods Resting-state QEEG data of total 265 patients were acquired retrospectively and parameters such as absolute power, relative power and peak frequency were analyzed from the data. Stroop test and Trail Making Test results as well as demographic features were reviewed for this study. The correlation of neurocognitive functions and brain electrical activities in each group were assessed and compared by correlation analysis. Results Compared with the OCD group, the schizophrenia group performed poorly in neurocognitive tests. Mean values of QEEG parameters in patients with OCD and schizophrenia did not show significant differences. Both absolute and relative power of alpha rhythm in central and frontal regions showed significant positive correlation with Stroop test results in OCD patients. Conclusions Findings in this study shows distinctive correlations between frontal executive dysfunction and frontal alpha rhythm in the OCD patients, both of which might be a candidate for endophenotype underlying obsessive rumination.

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참고문헌

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