대한한의학방제학회지 (Herbal Formula Science)

  • 제24권4호
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  • Pages.283-288
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  • 2016
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
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참옻 추출물의 MCF-7 인체 유방암 세포에서 증식 억제효과

Inhibitory effect of Rhus verniciflua Stokes extract in MCF-7 human breast cancer cells

  • 김민성 (부산대학교 한의학전문대학원) ;
  • 안원근 (부산대학교 한의학전문대학원) ;
  • 이장천 (부산대학교 한의학전문대학원)
  • Kim, Min Sung (Pusan National University School of Korean Medicine) ;
  • An, Won Gun (Pusan National University School of Korean Medicine) ;
  • Lee, Jang Cheon (Pusan National University School of Korean Medicine)
  • 투고 : 2016.11.03
  • 심사 : 2016.11.17
  • 발행 : 2016.11.30
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초록

Objectives : The purpose of this study was to investigate the anti-cancer effects of extract of Rhus verniciflua Stokes (RVS) in human breast cancer cell lines. Methods : In cultured human breast cancer MCF-7 cells, we investigated growth inhibitory effect of RVS. MCF-7 cells were cultured with various concentrations (0, 200, 300, and 400 ug/ml) of RVS at $37^{\circ}C$ for 24 h. We performed CCK-8 assay and flow cytometry for detection of Annexin V-PI staining. Results : As a result, RVS inhibits the cell growth and induction of apoptosis in dose dependent manner in MCF-7 breast cancer cells. Conclusion : RVS has anti-cancer activities and induced apoptosis in human breast cancer MCF-7 cells. Therefore we suggest that RVS can use as a novel class of anti-cancer drugs.

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참고문헌

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