Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Beneficial Effects of Oat (Avena sativa L.) Bran Extract in Loperamide-induced Constipated SD Rats

  • Lee, Sung-Gyu (Department of Medical Laboratory Science, College of Health Science, Dankook University) ;
  • Jang, Hyun-Joo (Taewoong Food Co., Ltd) ;
  • Kang, Hyun (Department of Medical Laboratory Science, College of Health Science, Dankook University)
  • Received : 2016.11.16
  • Accepted : 2016.12.06
  • Published : 2016.12.31
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Abstract

The efficacy of extracts of oat (Avena sativa L.) bran in loperamide-induced constipation in SD rats was evaluated. The rats were divided into six groups of five rats each. The animals in Group 1 (control) and Group 2 (constipated control) were administered with distilled water orally. Groups 3, 4 and 5 comprised of constipated rats administered 100, 200 and 300 mg/kg body weight per day of extract of oat (Avena sativa L.) bran respectively while Group 6 were constipated rats administered bisacodyl (0.25 mg/kg body weight). Constipation was induced by oral administration of loperamide. The feeding characteristics, body weight, fecal properties were monitored. The results show that oats (Avena sativa L.) bran possesses laxative effects in loperamide-induced constipated rats.

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References

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