Journal of Korean Biological Nursing Science

Korean society of Biological Nursing Science (한국기초간호학회)
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Current Interventions to Improve Adherence to Immunosuppressants in Liver Transplant Recipients: a Systematic Review

간이식 환자의 면역억제제 복용이행 관련 중재에 관한 체계적 문헌고찰

  • 김소희 (연세대학교 대학원) ;
  • 이영주 (연세대학교 대학원) ;
  • 이선영 (세브란스병원) ;
  • 추상희 (연세대학교 간호대학.김모임간호학연구소)
  • Received : 2016.01.28
  • Accepted : 2016.02.15
  • Published : 2016.02.29
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Abstract

Purpose: Adherence to immunosuppressants is the key to prevent organ rejection in organ transplant recipients. The purpose of this study was to investigate current interventions to improve adherence to immunosuppressants in liver transplant recipients. Methods: A systemic literature search was done using PubMed, Embase, Cochrane Library, CINAHL and four Korean databases to identify experimental studies reported in English or Korean up to and including 2015. We identified eight intervention studies on the adherence to immunosuppressants in liver transplant recipients independently reviewed by two reviewers. The quality and risk of bias of the selected studies were assessed. Results: Education, conversion of regimen, and text messaging were identified as intervention techniques to improve adherence. We found positive results in three out of four studies implementing educational strategies, but the results were not sufficient to draw a definite conclusion. Conversion from a twice-daily tacrolimus-based regimen to a once-daily tacrolimus extended-release formula was used in three adult-only studies and its effectiveness was confirmed. One study showed that improved adherence and outcomes were effected by using text messaging with pediatric patients. Conclusion: Future research is needed to facilitate interventions to improve adherence to immunosuppressants in various ages of patients including pediatric/adolescent liver transplant recipients.

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References

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