Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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iRhoms; Its Functions and Essential Roles

  • Lee, Min-Young (Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Nam, Ki-Hoan (Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Choi, Kyung-Chul (Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University)
  • Received : 2015.09.14
  • Accepted : 2015.11.06
  • Published : 2016.03.01
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Abstract

In Drosophila, rhomboid proteases are active cardinal regulators of epidermal growth factor receptor (EGFR) signaling pathway. iRhom1 and iRhom2, which are inactive homologs of rhomboid intramembrane serine proteases, are lacking essential catalytic residues. These are necessary for maturation and trafficking of tumor necrosis factor-alpha (TNF-${\alpha}$) converting enzyme (TACE) from endoplasmic reticulum (ER) to plasma membrane through Golgi, and associated with the fates of various ligands for EGFR. Recent studies have clarified that the activation or downregulation of EGFR signaling pathways by alteration of iRhoms are connected to several human diseases including tylosis with esophageal cancer (TOC) which is the autosomal dominant syndrom, breast cancer, and Alzheimer's disease. Thus, this review focuses on our understanding of iRhoms and the involved mechanisms in the cellular processes.

Keywords

References

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