Journal of the Korean Society of Manufacturing Process Engineers (한국기계가공학회지)

The Korean Society of Manufacturing Process Engineers (한국기계가공학회)
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A Study on Fabrication of 3D Porous Scaffold Combined with Polymer Deposition System and a Salt Leaching Method

폴리머 적층 시스템과 염 침출법을 결합한 3차원 다공성 인공지지체 제작

  • Shim, Hae-Ri (Department of Mechanical Engineering, Andong National UNIV.) ;
  • Sa, Min-Woo (Department of Mechanical Engineering, Andong National UNIV.) ;
  • Kim, Jong Young (Department of Mechanical Engineering, Andong National UNIV.)
  • 심해리 (국립안동대학교 기계공학과) ;
  • 사민우 (국립안동대학교 기계공학과) ;
  • 김종영 (국립안동대학교 기계공학과)
  • Received : 2015.12.22
  • Accepted : 2016.03.02
  • Published : 2016.10.31
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Abstract

In this study, we used a polymer deposition system, based on fused deposition modeling, to fabricate the 3D scaffold and then fabricated micro-pores on a 3D scaffold using a salt leaching method. Materials included polycaprolactone (PCL) and sodium chloride (NaCl). The 3D porous scaffolds were fabricated according to blending ratio such as PCL (70 wt%)/NaCl (30 wt%) and PCL (50 wt%)/NaCl (50 wt%). The 3D porous scaffolds were observed by scanning electron microscopy. The results showed that 3D porous scaffolds had a deposition width of $500{\mu}m$, contained a pore size of $500{\mu}m$ and below $100{\mu}m$. To evaluate the 3D porous scaffolds for bone tissue engineering, we carried out the cell proliferation experiment using a CCK-8 and a mechanical strength test using a universal testing machine. In summary, the 3D porous scaffold was found to be suitable for cancellous bone of human in accordance with the result of in-vitro cell proliferation and mechanical strength. Thus, a 3D porous scaffold could be a promising approach for effective bone regeneration.

Keywords

References

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