Asian Pacific Journal of Cancer Prevention

아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Salivary Levels of ErbB2 and CEA in Oral Squamous Cell Carcinoma Patients

  • Honarmand, Marieh (Oral and Dental Disease Research Center, Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences) ;
  • Farhad-Mollashahi, Leila (Oral and Dental Disease Research Center, Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences) ;
  • Nakhaee, Alireza (Department of Biochemistry, School of Medicine, Zahedan University of Medical Sciences) ;
  • Nehi, Masoume (Department of Oral Medicine, Dental School, Zahedan University of Medical Sciences)
  • 발행 : 2016.06.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Oral squamous cell carcinoma (OSCC) is one of the ten most common causes of cancer death worldwide. Assessment of molecular changes can help detect and control lesions. The aim of this study was evaluation of salivary levels of ErbB2 and CEA in OSCC patients. In this case-control study, 27 OSCC patients and 26 healthy controls participated. After obtaining consent and filling out a questionnaire, unstimulated saliva samples were collected from people in the morning for measurement of the two markers using ELISA. Data were analyzed using Mann Whitney U test in SPSS 19 software with P<0.05 considered significant. Subjects were in the age range of 40 to 65 years. \Salivary level CEA was elevated in OSCC samples ($42.6{\pm}21.1ng/ml$) as compared to those of controls ($22.6{\pm}22.1ng/ml$) (p< 0.01), but no significant variation was noted for ErbB2 ($5.2{\pm}1.8ng/ml$ and $4.93{\pm}2.14ng/ml$, p=0.28). The role of ErbB2 as a tumor marker in patients with OSCC must still be regarded as controversial and needs further studies to clarify any significance for early detection or screening. In contrast the salivary level of CEA may find application for early detection of patients.

키워드

참고문헌

  1. Abdullah S, Mustafa K, Gurhan B, Fatih B, Orhan A (2013). CEA and CA 19-9 are still valuable markers for the prognosis of colorectal and gastric cancer patients. Asian Pac J Cancer Prev, 14, 4289-94. https://doi.org/10.7314/APJCP.2013.14.7.4289
  2. Angiero F, Sordo RD, Dessy E, et al (2008). Comparative analysis of c-erbB-2(HER-2/Neu) in squamous cell carcinoma of the tongue: does over- expression exist? And what is its correlation with traditional diagnostic parameters. J Oral Pathol Med, 37,145-50.
  3. Bayrak M, OlmezO F, Kurt E,et al (2013). Prognostic significance of c-erbB2 over expression in patients with metastatic gastric cancer. Clin Transl Oncol, 15, 307-12 https://doi.org/10.1007/s12094-012-0921-0
  4. Bo H, Hui-Qing ZH, Shu-Ping X, et al (2015). Changing patterns of serum CEA and CA199 for evaluating the response to first-line chemotherapy in patients with advanced gastric adenocarcinoma. Asian Pac J Cancer Prev, 16, 3111-16. https://doi.org/10.7314/APJCP.2015.16.8.3111
  5. Boehm MK, Perkins S (2000). Structural models for carcinoembryonic antigen and it's complex with the single-chain FV antibody molecule. FEBS letters. J Oral MaxillofacPathol, 1, 6-11.
  6. Bonne NJ, Wong DT (2012). Salivary biomarker development using genomic, proteomic and metabolomics approaches. Genomic Med, 123, 75-82.
  7. Chen CH, Tsai TL, Yang Ys, Tsai CC (2007). Studies of the serum HER-2/Neu and squamous cell carcinoma-related antigen expression in patients with oral squamous cell carcinoma. J Oral Pathol Med, 36, 83-7. https://doi.org/10.1111/j.1600-0714.2007.00502.x
  8. Chopra V, Thayalan D, VS J, Annasamy R, et al (2015). Salivary Her2/neu levels in differentiation of oral premalignant disorders and oral squamous cell Carcinomas. Asian Pac J Cancer Prev, 16, 5773-7. https://doi.org/10.7314/APJCP.2015.16.14.5773
  9. Da Silva SD1, Cunha IW, Nishimoto IN, et al (2009). Clinicopathological significance of ubiquitin-specific protease 2a(USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas. Oral Oncol, 45, 134-9. https://doi.org/10.1016/j.oraloncology.2009.02.004
  10. Greenberg MS, Glick M, Ship JA (2008). Burket's Oral medicine. 11th ed. Hamilton: Bc Decker Inc, 96-171.
  11. Jie-Xian J, Yan W, Xiao-Qin X, et al(2014). Tumor markers for diagnosis, monitoring of recurrence and prognosis in patients with upper gastrointestinal tract cancer. Asian Pac J Cancer Prev, 15, 10267-72.
  12. Li-Kui Y, Xue-Qing S, Dong-Zhen M (2015).Value of combined detection of serum CEA, CA72-4, CA19-9 and TSGF in the Diagnosis of Gastric Cancer. Asian Pac J Cancer Prev, 16, 3867-70. https://doi.org/10.7314/APJCP.2015.16.9.3867
  13. Liu J, Duan Y (2012). Saliva potential media for disease diagnostics and monitoring. Oral Oncol, 48, 569-77. https://doi.org/10.1016/j.oraloncology.2012.01.021
  14. Normanno N, De Luca A, Bianco C, et al (2006). Epidermal growth factor receptor (EGFR) signaling in cancer. Gene, 366, 2-16. https://doi.org/10.1016/j.gene.2005.10.018
  15. Rafael N, Gideon B, Thomas SH, Raphael F (2006). Concomitant Aanalysis of salivary tumor markers: a new diagnostic tool for oral cancer. Clin Cancer Res, 12, 3979-84. https://doi.org/10.1158/1078-0432.CCR-05-2412
  16. Rautava J, Jee KJ, Miettinen PJ, et al (2008). ERBB receptors in developing, dysplastic and malignant oral epithelia. Oral Oncol, 44, 227-35. https://doi.org/10.1016/j.oraloncology.2007.02.012
  17. Sardari Y, Soheil P, Akbarpoor D. (2012). Her2/Neu expression in head and neck squamous cell carcinoma patient is not significantly elevated. Asian Pac J Cancer Prev, 13, 2891-6. https://doi.org/10.7314/APJCP.2012.13.6.2891
  18. Sebastian S, Settleman J, Reshkin SJ, et al (2006). The complexity of targeting EGFR signalling in cancer: from expression to turnover. Biochim Biophys Acta, 1766, 120-39.
  19. Soulieres D, Senzer NN, Vokes EE, et al (2004). Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol, 22, 77-85. https://doi.org/10.1200/JCO.2004.06.075
  20. Streckfus CF, Bigler L, Dellinger T, et al(2004). The expression of the c-erbB-2 receptor protein in glandular salivary secretions. J Oral Pathol Med, 33, 595-600. https://doi.org/10.1111/j.1600-0714.2004.00255.x
  21. Ulanovski D, Stern Y, Roizman P, et al (2004). Expression of EGFR and c-erbB2 as prognostic factors in cancer of the tongue. Oral Oncol, 40, 532-7. https://doi.org/10.1016/j.oraloncology.2003.11.004
  22. Yakabe T, Nakafusa Y, Sumi K, et al (2010). Clinical significance of CEA and CA 19-9 in postoperative follow-up of colorectal cancer. Ann Surg Oncol, 17, 2349-56. https://doi.org/10.1245/s10434-010-1004-5

피인용 문헌

  1. Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases vol.2018, pp.1875-8630, 2018, https://doi.org/10.1155/2018/6141845