Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
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Understanding of Medical Cannabis and its Regulations: A Suggestion for Medical and Scientific Needs

의료용 대마(大麻)의 이해 및 법적 규제에 대한 고찰: 대마의 치료적, 학술적 필요성 제고

  • Han, Kyungsun (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongguk University) ;
  • Lee, Myeong-Jong (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongguk University) ;
  • Kim, Hojun (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongguk University)
  • 한경선 (동국대학교 한의과대학 한방재활의학과학교실) ;
  • 이명종 (동국대학교 한의과대학 한방재활의학과학교실) ;
  • 김호준 (동국대학교 한의과대학 한방재활의학과학교실)
  • Received : 2016.11.15
  • Accepted : 2016.12.05
  • Published : 2016.12.30
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Abstract

In traditional medicine, Cannabis sativa L. has been used for variety of reasons. Old literatures delineate that Cannabis had been used as anesthetic and analgesic, or to reduce symptoms such as cough, paralysis and so on. Although Cannabis has a long history of medical use, it is illegal in many countries including South Korea. Controversy over decriminalization of Cannabis to allow cannabis for therapeutic use has been around for many years. In order to understand current knowledge on the therapeutic use of medical Cannabis, comprehension of cannabinoids and other constituents of Cannabis is important. Here we reviewed the pharmacological effect of Cannabis and current mandatory regulation over Cannabis in many countries to suggest necessity of research on medical Cannabis.

Keywords

References

  1. Hillig KW. Genetic evidence for speciation in Cannabis (Cannabaceae). Genet Resour Crop Evol. 2005 ; 52(2) : 161-80. https://doi.org/10.1007/s10722-003-4452-y
  2. Pain S. Cannabis: a potted history. Nature. 2015 ; 525(7570) : S10-1. https://doi.org/10.1038/525S10a
  3. Committee of Korean Medicine Textbook Compilation. Galenic pharmacology. Seoul : Younglimsa. 2006 : 291-2.
  4. Korea National Arboretum [Internet]. Pocheon: Korea National Arboretum; 2014 [cited 2016 Nov 4]. Available from: www.nature.go.kr.
  5. Heo J. Principles and practice of eastern medicine; donguibogam. Seoul : Donguibogam Publishing Company. 1994.
  6. Andre CM, Hausman JF, Guerriero G. Cannabis sativa: the plant of the thousand and one molecules. Front Pland Sci. 2016 ; 7 : 19.
  7. Todd AR. Chemistry of the hemp drugs. Nature. 1940 ; 146 : 829-30. https://doi.org/10.1038/146829a0
  8. Adams R, Loewe S, Jelinek C, Wolff H. Tetrahydrocannabinol homologs with marihuana activity. J Am Chem Soc. 1941 ; 63(7) : 1971-3. https://doi.org/10.1021/ja01852a052
  9. Pertwee RG. Cannabinoid pharmacology: the first 66 years. Br J Pharmacol. 2006 ; 147(S1) : 163-71.
  10. Kalant H. Medical use of cannabis: history and current status. Pain Res Manag. 2001 ; 6(2) : 80-91. https://doi.org/10.1155/2001/469629
  11. Devane WA, Dysarz FA, Johnson MR, Melvin LS, Howlett AC. Determination and characterization of cannabinoid receptor in rat rain. Mol Pharmacol. 1988 ; 34(5) : 605-13.
  12. Devane WA, Hanus L, Breuner A, Pertwee RG, Stevenson LA, Griffin G, et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 1992 ; 258(5090) : 1946-9. https://doi.org/10.1126/science.1470919
  13. Di Marzo V, Piscitelli F. The endocannabinoid system and its modulation by phytocannabinoids. Neurotherapeutics. 2015 ; 12(4) : 692-8. https://doi.org/10.1007/s13311-015-0374-6
  14. Felder CC, Joyce KE, Briley EM, Mansouri J, Mackie K, Blond O, et al. Comparison of the Paharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptor. Mol Pharmacol. 1995 ; 48(3) : 443-50.
  15. Choe S, Yang W, Park Y, Choi H, Chung H. Classification of Cannabis sativa L. by the contents of cannabinoids and the characteristics of stable isotope. Seoul : The Pharmaceutical Society of Korea. 2011 : 264.
  16. Englund AM, Stone J, Morrison PD. Cannabis in the arm: what can we learn from intravenous cannabinoid studies? Curr Pharmaceut Des. 2012; 18(32) : 4906-14. https://doi.org/10.2174/138161212802884618
  17. Burstein S. Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorgan Med Chem. 2015 ; 23(7) : 1377-85. https://doi.org/10.1016/j.bmc.2015.01.059
  18. Russo EB, Burnett A, Hall B, Parker KK. Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res. 2005 ; 30(8): 1037-43. https://doi.org/10.1007/s11064-005-6978-1
  19. Siger A, Nogala-Kalucka M, Lampart-Szczapa E. The content and antioxidant activity of phenolic compounds in cold-pressed plant oils. J Food Lipids. 2008 ; 15(2) : 137-49. https://doi.org/10.1111/j.1745-4522.2007.00107.x
  20. Werz O, Seegers J, Schaible AM, Weinigel C, Barz D, Koeberle A, et al. Cannflavins from hemp sprouts, a novel cannabinoid-free hemp food product, target microsomal prostaglandin-E2 synthase-1 and 5-lipoxygenase. Pharmanutr. 2014 ; 2(3) : 53-60. https://doi.org/10.1016/j.phanu.2014.05.001
  21. Fischedick JT, Hazekamp A, Erkelens T, Choi YH, Verpoorte R. Metabolic fingerprinting of Cannabis sativa L., cannabinoids and terpeenoids for chemotaxonomic and drug stardardization purposes, Phytochemistry. 2010 ; 71(17) : 2058-73. https://doi.org/10.1016/j.phytochem.2010.10.001
  22. Philipsen N, Butler RD. Medical marijuana: a primer on ehtics, evidence, and politics. J Nurse Pract. 2014 ; 10(9) : 633-40. https://doi.org/10.1016/j.nurpra.2014.05.015
  23. Weiss SR. The state of the science on the therapeutic potential of marijuana and Cannabinoids [Internet]. Bethesda, MD: National Institute of Drug Abuse; 2016 [cited 2016 Nov 8]. Avilable from: https://www.judiciary.senate.gov/imo/media/doc/07-13-16%20Weiss%20Testimony.pdf.
  24. Walsh Z, Callaway R, Belle-Isle L, Capler R, Kay R, Lucas P, et al. Cannabis for therapeutic purposes: patient characteristics, access, and reasons for use. Int J Drug Policy. 2013 ; 24(6) : 511-6. https://doi.org/10.1016/j.drugpo.2013.08.010
  25. Reinarman C, Nunberg H, Lanthier F, Heddleston T. Who are medical marijuana patients? Population characteristics from nine California assessment clinics. J Psychoact Drugs. 2011 ; 43(2) : 128-35. https://doi.org/10.1080/02791072.2011.587700
  26. Amar MB. Cannabinoids in medicine: a review of their therapeutic potential. J Ethnopharmacol. 2006 ; 105(1) : 1-25. https://doi.org/10.1016/j.jep.2006.02.001
  27. van Amsterdam J, Brunt T, van den Brink W. The adverse health effects of synthetic cannabionoids with emphasis on psychosis-like effects. J Psychopharmacol. 2015 ; 29(3) : 254-63. https://doi.org/10.1177/0269881114565142
  28. Crean RD, Crane NA, Mason BJ. An evidence-based review of acute and long-term effects of cannabis use on executive cognitive functions. J Addict Med. 2011 ; 5(10) : 1-8. https://doi.org/10.1097/ADM.0b013e31820c23fa
  29. Tuyp BJ. The adverse health effects of persistent cannabis use: Review & recommendations for change. UBC Med J. 2013 : 5(1) ; 24-9.
  30. Hall W. What has research over the past two decades revealed about the adverse health effects of recreational cannabis use? Addiction. 2014 ; 110(1) : 19-35. https://doi.org/10.1111/add.12703
  31. Lichtman A, Martin B. Cannabinoid tolerance and dependence. Handb Exp Pharmacol. 2005 ; 168 : 691-717.
  32. Hirvonen J, Goodwin RS, Li CT, Terry GE, Zoghbi SS, Morse C, et al. Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Mol Psychiatry. 2012 ; 17(6) : 642-9. https://doi.org/10.1038/mp.2011.82
  33. Budney A, Hughes J. The cannabis withdrawal syndrome. Curr Opin Psychiatry. 2006 ; 19(3) : 233-8. https://doi.org/10.1097/01.yco.0000218592.00689.e5
  34. Rubino T, Parolaro D. The impact of exposure to cannabinoids in adolescence: insights from animal models. Biol Psychiatry. 2016 ; 79(7) : 578-85. https://doi.org/10.1016/j.biopsych.2015.07.024
  35. Korea Ministry of Government Legislation [Internet]. Sejong: Korea Ministry of Government Legislation; [cited 2016 Nov 8]. Available from: http://www.law.go.kr/lsInfoP.do?lsiSeq=180797&ancYd=20160203&efYd=20160203&ancNo=14019#0000.
  36. Choi S. Policy of reaction regarding Cannabis. Korean Assoc Policy Studies Autumn Meet. 2014 ; 29 : 45.
  37. Lee CK. The constituents of Korean Cannabis. J Pharm Soc Korea. 1973 ; 17 : 21-6.
  38. Moon YH, Lee BH, Jeong BC, Kim YU, Kim GY. Breeding history of non-drug type hemp variety "Cheungsam" and it's characteristics. Korean J Intl Agri. 2002 ; 14(2) : 119-26.
  39. Kennedy B. How Israel has become global leader in cannabis research [Internet]. Denver, CO: The Cannabist; [cited 2016 Nov 8]. Available from: http://www.thecannabist.co/2016/09/28/israel-cannabis-research/63987/.
  40. Hoffmann DE, Weber E. Medical marijuana and the law. N Engl J Med. 2010 ; 362(16) : 1453-57. https://doi.org/10.1056/NEJMp1000695
  41. Bifulco M, Pisanti S. Medical use of cannabis in europe. EMBO Rep. 2015 ; 16(2) : 130-2. https://doi.org/10.15252/embr.201439742
  42. Spithoff S, Emerson B, Spithoff A. Cannabis legalization: adhering to public health best practice. CMAJ. 2015 ; 187(16) : 1211-6. https://doi.org/10.1503/cmaj.150657
  43. De Petroclellis L, Ligresti A, Moriello AS, Allara M, Bisogno T, Petrosino S. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Br J Pharmacol. 2011 ; 163(7) : 1479-94. https://doi.org/10.1111/j.1476-5381.2010.01166.x
  44. Englund AM, Stone J, Morrison PD. Cannabis in the arm: what can we learn from intravenous cannabinoid studies? Curr Pharmacetu Des. 2012 ; 18(32) : 4906-14. https://doi.org/10.2174/138161212802884618
  45. Wagner H, Ultrich-Merzenich G. Syndergy research: appreoaching a new generation of phytopharmaceuticals. Phytomedicine. 2009 ; 16(2) : 97-110. https://doi.org/10.1016/j.phymed.2008.12.018
  46. Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effect. Br J Pharmacol. 2011 ; 163(7) : 1344-64. https://doi.org/10.1111/j.1476-5381.2011.01238.x
  47. Mehra R, Moore BA, Crothers K, Tetrault J, Fiellin DA. The association between marijuana smoking and lung cancer: a systematic review. Arch Intern Med. 2006 ; 166(13) : 1359-67. https://doi.org/10.1001/archinte.166.13.1359
  48. Gieringer DH. Cannabis "Vaporization" a promising strategy for smoke harm reduction. J Cannabis Ther. 2001 ; 1(3-4) : 153-70. https://doi.org/10.1300/J175v01n03_10
  49. Perez J. Combined cannabinoid therapy via an oromucosal spray. Drugs Today. 2006 ; 42(8) : 495-503. https://doi.org/10.1358/dot.2006.42.8.1021517
  50. Politi M, Peschel W, Wilson N, Zloh M, Prieto JM, Heinrich M. Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on ${\Delta}$ 9-THC and ${\Delta}$ 9-THC-acid. Phytochemistry. 2008 ; 69(2) : 562-70. https://doi.org/10.1016/j.phytochem.2007.07.018
  51. Charavarty I, Sengupta D, Bhattacharyya P, Ghosh JJ. Effect of treatment with cannabis extract on the water and glycogen contents of the uterus in normal and estradiol-treated prepubertal rats. Toxicol Appl pharmacol. 1975 ; 34(3) : 513-6. https://doi.org/10.1016/0041-008X(75)90145-3

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