References
- Rocca, W. A., Petersen, R. C., Knopman, D. S., Hebert, L. E., Evans, D. A., Hall, K. S., Ga,o S., Unverzagt, F. W., Langa, K. M., Larson, E. B. and White, L. R. (2011) Trends in the incidence and prevalence of Alzheimer’s disease, dementia, and cognitive impairment in the United States. Alzheimers Dement 7: 80-93. https://doi.org/10.1016/j.jalz.2010.11.002
- 조맹제, 김기웅, 김명희, 김문두, 김봉조, 김신겸, 김정란(2008) 치매 노인 유병률 조사, 보건복지가족부, 서울, 한국.
- Bartus, R. T., Dean, R. L. 3rd., Beer, B. and Lippa, A. S. (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217: 408-414. https://doi.org/10.1126/science.7046051
-
Chang, J. S., Lee, B. S. and Kyung, Y. G. (1992) Changes in
$\gamma$ -amino butyric acid(GABA) and the main constituents by a treatment conditions and of an aerobically treated green tea leaves. J. Korean Food Sci. Technol. 24: 315-319. - Choi, W. H., Um, M. Y., Ahn, J. Y., Kim, S. R., Kang, M. H. and Ha, T. Y. (2004). Acetylcholinesterase inhibitory activity and protective effect against cytotoxicity of perilla seed methanol extract. J. Korean Food Sci. Technol. 36: 1026-1031.
- Davies, P. and Maloney, A. J. (1976) Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2: 1403.
- Dawson, G. R., Bentley, G., Draper, F., Rycroft, W., Iversen, S. D. and Pagella, P. G. (1991) The behavioral effects of hepatic physostigmine: a new cholinesterase inhibitor, interests of long term and working memory in rodents. Pharmacol. Biochem. Behav. 39: 865-871. https://doi.org/10.1016/0091-3057(91)90045-4
- Rogers, S. L., Doody, R. S., Mohs, R. C., and Friedhoff, L. T. (1998) Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Donepezil Study Group. Arch. Intern. Med. 158: 1021-1031. https://doi.org/10.1001/archinte.158.9.1021
- Rosler, M. A., R. Cicin-Sain, A., Gauthier, S., Agid, Y., Dal- Bianco, P., Stahelin, H. B., Hartman, R. and Gharabawi, M. (1999) Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial. BMJ. 318(7184): 633-638.
- 조태동 (2011) 한국의 허브, 대원사, 서울.
- Kim, J. H., Cho, C. W., Tai, B. H., Yang, S. Y., Choi, G. S., Kang, J. S. and Kim, Y. H. (2015) Soluble epoxide hydrolase inhibitory activity of selaginellin derivatives from Selatinella tamariscina. Molecules 20: 21405-21414. https://doi.org/10.3390/molecules201219774
- Nguyen, P. H., Ji, D. J., Han, Y. R., Choi, J. S. Rhyu, D. Y., Min, B. S. and Woo, M. H. (2015) Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects. Bioorg. Med. Chem. 23: 3730-3737. https://doi.org/10.1016/j.bmc.2015.04.007
- Hsin, C. H., Wu, B. C., Chuang, C. Y., Yang, S. F., Hsieh, Y. H., Ho, H. Y., Lin, H. P., Chen, M. K. and Lin, C. W. (2013) Selaginella tamariscina extract suppresses TPA-induced invasion and metastasis through inhibition of MMP-9 in human nasopharyngeal carcinoma HONE-1 cells. BMC Complementary & Alternative Medicine 13: 234. https://doi.org/10.1186/1472-6882-13-234
- Yang, J. S., Lin, C. W., Hsieh, Y. S., Cheng, H. L., Leu, K. H., Yang, S. F. and Lu, K. S. (2013) Selaginella tamariscina( Beauv.) processes antimetastatic effects on human osteosarcoma cells by decreasing MMP-2 and MMP-9 secretions via p38 and Akt signaling pathways. Food Chem. Toxicol. 59: 801-807. https://doi.org/10.1016/j.fct.2013.06.028
- Cao, Y., Wu, Y., Zhou, X., Qian, F., Fan, H. and Wang, Q. (2012) Simultaneous determination of seleginellins and flavonoids in Selaginella tamariscina and S. pulvinata by HPLC. Zhongguo Zhong Yao Za Zhi 37: 1254-1258.
- Zhang, G. G., Jing, Y., Zhang, H. M., Ma, E.L., Guan, J., Xue, F. N., Liu, H. X. and Sun, X. Y. (2012) Isolation and cytotoxic activity of selaginellin derivative and biflavonoids from Selaginella tamariscina. Planta. Med. 78: 390-392. https://doi.org/10.1055/s-0031-1298175
- Zhang, Y. X., Li, Q. Y., Yan, L. L. and Shi, Y. (2011) Structural characterization and identification of flavonoids in Selaginella tamariscina by liquid chromatography-diodearray detection/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 25: 2173-2186. https://doi.org/10.1002/rcm.5090
- Jung, H. J., Park, K., Lee, I. S., Kim, H. S., Yeo, S. H., Woo, E. R. and Lee, D. G. (2007) S-phase accumulation of Candida albicans by anticandidal effect of amentoflavone isolated from Selaginella tamariscina. Biol. Pharm. Bull. 30: 1969-1971. https://doi.org/10.1248/bpb.30.1969
- Lee, S. H., Oh, W. H., Kim, B. Y., Ahn, S. C., Kang, D.O., Shin, D. I., Kim, J., Mheen, T. I. and Ahn, J. S. (1996) Inhibition of phospholipase C gamma 1 activity by amentoflavone isolated from Selaginella tamariscina. Planta Med. 62: 293-296. https://doi.org/10.1055/s-2006-957887
-
Sasaki, H., Kitoh, Y., Tsukada, M., Miki, K., Koyama, K., Juliawaty, L. D., Hakim, E. H., Takahashi, K. and Kinoshita, K. (2015) Inhibitory activities of biflavonoids against amyloid-
$\beta$ peptide 42 cytotoxicity in PC-12 cells. Bioorg. Med. Chem. Lett. 25: 2831-2833. https://doi.org/10.1016/j.bmcl.2015.04.106 - Zhang, Z., Sun, T., Niu, J. G., He, Z. Q., Liu, Y. and Wang, F. (2015) Amentoflavone protects hippocampal neurons: antiinflammatory, antioxidative and anti apoptotic effects. Neural. Regen. Res. 14: 969-978.
- Morris, R. (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J. NeuroSci. Methods 11: 47-60. https://doi.org/10.1016/0165-0270(84)90007-4
- Van der Zee, E. A., Biemans, B. A. M., Gerkema, M. P. and Daan, S. (2004) Habituation to a test apparatus during associative learning is sufficient to enhance muscarinic acethylcholine receptor-immunoreactivity in rat suprachiasmatic nucleus. J. Neuro. Sci. Res. 78: 508-519. https://doi.org/10.1002/jnr.20300
- Hestrin, S. (1949) The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine and its analytical application. J. Biol. Chem. 180: 249-261.
- Ohkawa, H., Ohishi, N. and Yagi, K. (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95: 351-358. https://doi.org/10.1016/0003-2697(79)90738-3
- Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951) Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265-275.
- Kruger, N. J. (1994) The Bradford method for protein quantitation. Methods Mol. Biol. 32: 9-15
- Bartus, R. T. (2000) On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp. Neurol. 163: 495-529. https://doi.org/10.1006/exnr.2000.7397
- Casado, A., Encarnacion Lopez-Fernandez, M., Concepcion Casado, M. and de La Torre, R. (2008). Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias. Neurochem. Res., 33: 450-458. https://doi.org/10.1007/s11064-007-9453-3
- Woolf, N. J. (1997) A possible role for cholinergic neurons of the basal forebrain and pontomesencephalon in consciousness. Conscious Cong. 6: 574-596. https://doi.org/10.1006/ccog.1997.0319
- Wesnes, K. A., Simpson, P. M., White, L., Pinker S., Jertz, G., Murphy, M. and Sieqfried, K. (1991) Cholinesterase inhibition in the scopolamine model of dementia. Ann. N. Y. Acad. Sci. 640: 268-271. https://doi.org/10.1111/j.1749-6632.1991.tb00231.x
- Palmer, D., Creighton, S., Prado, V. F., Prado, M. A., Choleris, E. and Winters, B. D. (2016) Mice deficient for striatal vesicular acetylcholine transporter (VAChT) display impaired short-term but normal long-term object recognition memory. Behav. Brain Res. 311: 267-278. https://doi.org/10.1016/j.bbr.2016.05.050
- Ho, Y. S., and Crapo, J. D. (1988). Isolation and characterization of complementary DNAs encoding human manganese- containing superoxide dismutase. FEBS. Lett. 229: 256-260. https://doi.org/10.1016/0014-5793(88)81136-0