Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Sirt1 and the Mitochondria

  • Tang, Bor Luen (Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore)
  • Received : 2015.11.24
  • Accepted : 2015.12.31
  • Published : 2016.02.29
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Abstract

Sirt1 is the most prominent and extensively studied member of sirtuins, the family of mammalian class III histone deacetylases heavily implicated in health span and longevity. Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-$1{\alpha}$ (PGC-$1{\alpha}$) has been extensively implicated in metabolic control and mitochondrial biogenesis, which was proposed to partially underlie Sirt1's role in caloric restriction and impacts on longevity. The notion of Sirt1's regulation of PGC-$1{\alpha}$ activity and its role in mitochondrial biogenesis has, however, been controversial. Interestingly, Sirt1 also appears to be important for the turnover of defective mitochondria by mitophagy. I discuss here evidences for Sirt1's regulation of mitochondrial biogenesis and turnover, in relation to PGC-$1{\alpha}$ deacetylation and various aspects of cellular physiology and disease.

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References

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  91. Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1α/NF-κB signaling axis vol.40, pp.4, 2016, https://doi.org/10.1080/10799893.2020.1738483
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  96. Insights into the Role of microRNAs in Colorectal Cancer (CRC) Metabolism vol.12, pp.9, 2020, https://doi.org/10.3390/cancers12092462
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  98. Anti-Obesity Effects of Soybean Embryo Extract and Enzymatically-Modified Isoquercitrin vol.10, pp.10, 2016, https://doi.org/10.3390/biom10101394
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  104. Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch vol.10, pp.None, 2016, https://doi.org/10.1038/s41598-020-58999-0
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  108. Susceptibility to COVID‐19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants vol.35, pp.1, 2016, https://doi.org/10.1002/jbt.22626
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  112. The Oxidative Stress and Chronic Inflammatory Process in Chagas Disease: Role of Exosomes and Contributing Genetic Factors vol.2021, pp.None, 2016, https://doi.org/10.1155/2021/4993452
  113. SIRT1 is Required for Exercise-Induced Beneficial Effects on Myocardial Ischemia/Reperfusion Injury vol.14, pp.None, 2016, https://doi.org/10.2147/jir.s300997
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  115. Inhibition of miRNA-155 Alleviates High Glucose-Induced Podocyte Inflammation by Targeting SIRT1 in Diabetic Mice vol.2021, pp.None, 2016, https://doi.org/10.1155/2021/5597394
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  117. Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis vol.8, pp.None, 2016, https://doi.org/10.3389/fnut.2021.635232
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  120. Sodium-Glucose Cotransporter 2 Inhibitors Work as a “Regulator” of Autophagic Activity in Overnutrition Diseases vol.12, pp.None, 2016, https://doi.org/10.3389/fphar.2021.761842
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  123. Effect of Leptin in Human Sertoli Cells Mitochondrial Physiology vol.28, pp.3, 2021, https://doi.org/10.1007/s43032-020-00328-x
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  128. 13C Metabolic Flux Analysis Indicates Endothelial Cells Attenuate Metabolic Perturbations by Modulating TCA Activity vol.11, pp.4, 2021, https://doi.org/10.3390/metabo11040226
  129. SRT1720 Pretreatment Promotes Mitochondrial Biogenesis of Aged Human Mesenchymal Stem Cells and Improves Their Engraftment in Postinfarct Nonhuman Primate Hearts vol.30, pp.7, 2016, https://doi.org/10.1089/scd.2020.0149
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  131. Nicotinamide ameliorates energy deficiency and improves retinal function in Cav‐1‐/‐ mice vol.157, pp.3, 2016, https://doi.org/10.1111/jnc.15266
  132. Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson’s disease model via AMPK activation vol.42, pp.5, 2016, https://doi.org/10.1038/s41401-020-0487-2
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  147. Ginsenoside Rg3 alleviates septic liver injury by regulating the lncRNA TUG1/miR-200c-3p/SIRT1 axis vol.18, pp.1, 2016, https://doi.org/10.1186/s12950-021-00296-2
  148. RETRACTED ARTICLE: MiR-34a inhibitor protects mesenchymal stem cells from hyperglycaemic injury through the activation of the SIRT1/FoxO3a autophagy pathway vol.12, pp.1, 2021, https://doi.org/10.1186/s13287-021-02183-2
  149. Dietary Phytoestrogens and Their Metabolites as Epigenetic Modulators with Impact on Human Health vol.10, pp.12, 2021, https://doi.org/10.3390/antiox10121893
  150. Potential Health Benefits of Whole Grains: Modulation of Mitochondrial Biogenesis and Energy Metabolism vol.69, pp.47, 2021, https://doi.org/10.1021/acs.jafc.1c05527
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  152. Protective role of mitoquinone against impaired mitochondrial homeostasis in metabolic syndrome vol.61, pp.22, 2021, https://doi.org/10.1080/10408398.2020.1809344
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  155. Mitochondrial homeostasis and redox status in cardiovascular diseases: Protective role of the vagal system vol.178, pp.None, 2022, https://doi.org/10.1016/j.freeradbiomed.2021.12.255
  156. Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function vol.76, pp.1, 2016, https://doi.org/10.1016/j.jhep.2021.09.008
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  158. Bicalutamide Exhibits Potential to Damage Kidney via Destroying Complex I and Affecting Mitochondrial Dynamics vol.11, pp.1, 2022, https://doi.org/10.3390/jcm11010135
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