Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Five Genes Regulated by Oryctes rhinoceros nudivirus Infection in the Intestinal Tube of Allomyrina dichotoma

장수풍뎅이(Allomyrina dichotoma)에 Oryctes rhinoceros nudivirus 감염에 의해서 유전자 발현이 조절되는 5개의 유전자

  • Yoo, Bo-Kyung (Department of Biomedical Laboratory Science, College of Health & Welfare, Kyungwoon University) ;
  • Kwon, Kisang (Department of Anatomy and Cell Biology, College of Medicine, Chungnam National University) ;
  • Ko, Young Hwa (Department of Biomedical Laboratory Science, College of Health & Welfare, Kyungwoon University) ;
  • Lee, Eun Ryeong (Department of Anatomy and Cell Biology, College of Medicine, Chungnam National University) ;
  • Choi, Ji-Young (Applied Entomology Division, National Academy of Agricultural Science, RDA) ;
  • Kwon, O-Yu (Department of Biomedical Laboratory Science, College of Health & Welfare, Kyungwoon University)
  • 유보경 (충남대학교 의학전문대학원 해부학교실) ;
  • 권기상 (경운대학교 임상병리학과) ;
  • 고영화 (충남대학교 의학전문대학원 해부학교실) ;
  • 이은령 (경운대학교 임상병리학과) ;
  • 최지영 (농진청 국립농업과학원 곤충산업과) ;
  • 권오유 (충남대학교 의학전문대학원 해부학교실)
  • Received : 2016.10.10
  • Accepted : 2016.10.17
  • Published : 2016.11.30
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Abstract

Korean rhinoceros beetles (Allomyrina dichotoma), which can be found in broad-leaved forests in mountainous habitats and lives for around one year in wild. This beetle is currently popular as a pet and traditionally regarded as a medicine for liver-related diseases in Korea. It is reported that the economic losses in the mass-rearing facilities by virus infection have been increased since the 2010s in Korea. The causing virus for the A. dichotoma was firstly reported as an Oryctes rhinoceros nudivirus (OrNV) in 2015. We, here, observes that serious morphological changes in the intestinal tube from the OrNV-infected beetles, and report five genes, which are regulated by OrNV infection in the intestine; Krueppel-like factor 15 (Klf15), Endoplasmic reticulum aminopeptidase 2 (ERAP2), U5 small nuclear ribonucleoprotein 200 kDa helicase (Snrnp200), Muscleblind-like protein 2a (mbnl2a), and MIMI_L93. The results may provide a clue to the early diagnosis and disease treatment during the mass-rearing facilities of the A. dichotoma.

최근에 장수풍뎅이(Allomyrina dichotoma)는 관상용으로 인기가 높으며, 애벌레는 건강보조식품으로 주목을 받고 있다. 장수풍뎅이의 대량사육 시 발생하는 질병의 원인이 Oryctes rhinoceros nudivirus (OrNV)인 것이 2015년에 처음 보고되었다. 그러나 아직 정확한 진단, 발병기전과 치료방법을 찾지 못하고 있으며 곤충 사육농가에 매년 심각한 경제적 손실을 입고 있다. 본 연구는 장수풍뎅이의 대량사육 시 발생하는 OrNV질병의 조기진단과 치료에 실마리를 제공하기 위하여 OrNV에 감염된 장수풍뎅이의 장(intestine)에서 유전자발현이 조절되는 Klf15, ERAP2, Snrnp200, mbnl2a, MIMI_L93를 보고한다.

Keywords

References

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