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8 - 9세 어린이의 Molar-Incisor Hypomineraization의 원인 및 유병률에 대한 조사연구

Prevalence and Etiology of Molar Incisor Hypomineralization in Children Aged 8 - 9 Years

  • 김태형 (전북대학교 치의학전문대학원 소아치과학교실 및 구강생체과학연구소) ;
  • 정일용 (전북대학교 치의학전문대학원 소아치과학교실 및 구강생체과학연구소) ;
  • 이대우 (전북대학교 치의학전문대학원 소아치과학교실 및 구강생체과학연구소) ;
  • 김재곤 (전북대학교 치의학전문대학원 소아치과학교실 및 구강생체과학연구소) ;
  • 양연미 (전북대학교 치의학전문대학원 소아치과학교실 및 구강생체과학연구소)
  • Kim, Taehyoung (Department of Pediatric Dentistry and Institute of Oral Bioscience, School of Dentistry, Chonbuk National University) ;
  • Jeong, Ilyong (Department of Pediatric Dentistry and Institute of Oral Bioscience, School of Dentistry, Chonbuk National University) ;
  • Lee, Daewoo (Department of Pediatric Dentistry and Institute of Oral Bioscience, School of Dentistry, Chonbuk National University) ;
  • Kim, Jaegon (Department of Pediatric Dentistry and Institute of Oral Bioscience, School of Dentistry, Chonbuk National University) ;
  • Yang, Yeonmi (Department of Pediatric Dentistry and Institute of Oral Bioscience, School of Dentistry, Chonbuk National University)
  • 투고 : 2016.05.13
  • 심사 : 2016.07.07
  • 발행 : 2016.11.30

초록

본 연구는 전주시 8 - 9세 어린이 950명을 대상으로 임상 검사를 통해 MIH 유병률과 MIH 증상을 보이는 치아의 저광화 정도 및 상태에 대해 알아보았으며, MIH 위험 요인에 관한 설문조사를 통해 병인을 조사하였다. MIH 유병률은 7.1%였으며, 이환된 치아의 저광화 정도는 통계적으로 유의한 차이를 보였다(p < 0.05). 제1대구치가 절치에 비해 이환 빈도가 높았으며, 특히 MIH code 2a와 3은 제1대구치에서만 관찰되었다(p < 0.05). 위험 요인에 대한 설문조사에서는 산모의 스트레스와 항생제 복용, 출생 시 저체중과 출생 후 3년 이내의 입원 경력, 빈번한 호흡기 감염, 고열 그리고 항생제의 장기간 복용이 MIH와 유의한 관련성을 보였다(p < 0.05). 위험 요인들 상호간의 관련성은 임신기간 동안 항생제를 복용한 경우에서만 높은 연관성을 보였다(p < 0.05).

This study examined the prevalence of MIH and severity of hypomineralization exhibited by MIH-affected tooth based on the clinical examination of 950 children between age 8 and 9 in the city of Jeonju. The etiology was also studied utilizing a questionnaire on the MIH risk factors. The prevalence of MIH was 7.1%. The examined MIH-affected teeth showed statically significant difference in the degree of their hypomineralization (p < 0.05). The permanent first molar showed greater frequency of MIH compared to the permanent incisor, and the MIH code 2a and 3 were only observed in the permanent first molar (p < 0.05). From the questionnaire, showed the significant relationship between the occurrence of MIH and risk factors such as stress and antibiotics intake during pregnancy, low birth weight and events like hospital admission, frequent respiratory infection, high fever and long-term antibiotics intake within the three years of children's lives (p < 0.05). Among all the possible risk factors, the antibiotics intake during pregnancy only showed high correlation with the incidence of MIH (p < 0.05).

키워드

참고문헌

  1. Weerheijm KL : Molar incisor hypomineralization (MIH): clinical presentation, aetiology and management. Dental Update, 31:9-12, 2004. https://doi.org/10.12968/denu.2004.31.1.9
  2. Weerheijm KL, Jalevik B, Alaluusua S : Molarincisor hypomineralisation. Caries Res, 35:390-391, 2001. https://doi.org/10.1159/000047479
  3. Fayle SA : Molar incisor hypomineralization: restorative management. Eur J Paediatr Dent, 4:121-126, 2003.
  4. Alaluusua S : Aetiology of Molar-Incisor Hypomineralisation: A systematic review. Eur Arch Paediatr Dent, 11:53-58, 2010. https://doi.org/10.1007/BF03262713
  5. Crombie F, Manton D, Kilpatrick N : Aetiology of molar-incisor hypomineralization: a critical review. Int J Paediatr Dent, 19:73-83, 2009. https://doi.org/10.1111/j.1365-263X.2008.00966.x
  6. Fagrell TG, Ludvigsson J, Koch G, et al. : Aetiology of severe demarcated enamel opacities: an evaluation based on prospective medical and social data from 17,000 children. Swed Dent J, 35:57-67, 2011.
  7. Alaluusua S, Lukinmaa PL, Vartiainen T, et al. : Developing teeth as biomarker of dioxin exposure. Lancet, 353:206, 1999.
  8. Brogardh-Roth S, Matsson L, Klingberg G : Molarincisor hypomineralization and oral hygiene in 10 to 12-yr-old Swedish children born preterm. Eur J Oral Sci, 119:33-39, 2011. https://doi.org/10.1111/j.1600-0722.2011.00792.x
  9. Jalevik B, Noren JG : Enamel hypomineralization of permanent first molars: a morphological study and survey of possible aetiological factors. Int J Paediatr Dent, 10:278-289, 2000.
  10. Weerheijm KL, Duggal M, Hallonsten AL, et al. : Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003. Eur J Paediatr Dent, 4:110-113, 2003.
  11. Jalevik B : Prevalence and diagnosis of Molar-Incisor-Hypomineralisation (MIH): a systematic review. Eur Arch Paediatr Dent, 11:59-64, 2010. https://doi.org/10.1007/BF03262714
  12. Shin JH, An UJ, Jeong TS, et al. : The prevalence of Molar-incisor hypomineralization and status of first molars in primary school children. J Korean Acad Pediatr Dent, 37:179-185, 2010.
  13. William V, Messer LB, Burrow MF : Molar Incisor Hypomineralization Review and Recommendations for Clinical Management. Pediatr Dent, 28:224-232, 2006.
  14. Jälevik B, Klingberg GA : Dental treatment, dental fear and behaviour management problems in children with severe enamel hypomineralization of their permanent first molars. Int J Paediatr Dent, 12:24-32, 2002.
  15. Molar Incisor Hypomineralization: Morphological, Aetiological, Epidemiological and Clinical Considerations. Assessment service. Available from URL: http://cdn.intechopen.com/pdfs/32183.pdf (Assessd on November 3, 2015).
  16. Ng JJ, Eu OC, Nair R, Hong CH : Prevalence of molar incisor hypomineralization (MIH) in Singaporean children. Int J Paediatr Dent, 25:73-78, 2015. https://doi.org/10.1111/ipd.12100
  17. Lygidakis NA, Dimou G, Briseniou E : Molarincisor-hypomineralisation (MIH). Retrospective clinical study in Greek children. I. Prevalence and defect characteristics. Eur Arch Paediatr Dent, 9:200-206, 2008. https://doi.org/10.1007/BF03262636
  18. Garcia-Margarit M, Catala-Pizarro M, Montiel-Company JM, Almerich-Silla JM : Epidemiologic study of molar-incisor hypomineralization in 8-yearold Spanish children. Int J Paediatr Dent, 24:14-22, 2014. https://doi.org/10.1111/ipd.12020
  19. Souza JF, Costa-Silva CM. Cordeiro RC, et al. : Molar incisor hypomineralisation: possible aetiological factors in children from urban and rural areas. Eur Arch Paediatr Dent, 13:164-170, 2012. https://doi.org/10.1007/BF03262865
  20. Calderara PC, Gerthoux PM, Alaluusua S, et al. : The prevalence of Molar Incisor Hypomineralisation (MIH) in a group of Italian school children. Eur J Paediatr Dent, 6:79-83, 2005.
  21. Jasulaityte L, Veerkamp JS, Weerheijm KL : Molar incisor hypomineralization: review and prevalence data from the study of primary school children in Kaunas/Lithuania. Eur Arch Paediatr Dent, 8:87-94, 2007. https://doi.org/10.1007/BF03262575
  22. Ghanim A, Morgan M, Marino R, Manton D, et al. : Molar-incisor hypomineralisation: prevalence and defect characteristics in Iraqi children. Int J Paediatr Dent, 21:413-421, 2011. https://doi.org/10.1111/j.1365-263X.2011.01143.x
  23. Kevrekidou A, Kosma I, Arapostathis K, Kotsanos N : Molar Incisor Hypomineralization of Eight- and 14-year-old Children: Prevalence, Severity, and Defect Characteristics. Pediatr Dent, 37:455-461, 2015.
  24. Baroni C, Marchionni S : MIH supplementation strategies: prospective clinical and laboratory trial. J Dent Res, 90:371-376, 2011. https://doi.org/10.1177/0022034510388036
  25. Brook AH : Multilevel complex interactions between genetic, epigenetic and environmental factors in the aetiology of anomalies of dental development. Arch Oral Biol, 54:S3-17, 2009. https://doi.org/10.1016/j.archoralbio.2009.09.005
  26. Weerheijm KL : Molar incisor hypomineralization (MIH). Eur J Paediatr Dent, 4:114-120, 2003.
  27. Soviero V, Haubek D, Poulsen S, et al. : Prevalence and distribution of demarcated opacities and their sequelae in permanent 1st molars and incisors in 7 to 13-year-old Brazilian children. Acta Odontol Scand, 67:170-175, 2009. https://doi.org/10.1080/00016350902758607
  28. Alaluusua S : Aetiology of molar-incisor hypomineralisation: a systematic review. Eur Arch Paediatr Dent, 11:53-58, 2010. https://doi.org/10.1007/BF03262713
  29. Pitiphat W, Luangchaichaweng S, Chansamak N, et al. : Factors associated with molar incisor hypomineralization in Thai children. Eur J Oral Sci, 122:265-270, 2014. https://doi.org/10.1111/eos.12136
  30. Stress doesn't always look stressful. Psychologist Connie Lillas uses a driving analogy to describe the three most common ways people. Assessment service. Available from URL: http://www.naturalpath.net.au/articles/2012/feb/4/stress-and-you/ (Assessd on July 5, 2015).
  31. Helpdesk Research Report: The Impact of Conflict on Women's Education. Employment and Health Care 2009. Assessment service. Available from URL: http://www.gsdrc.org/docs/open/hd588.pdf (Assessd on September 4, 2015).
  32. Laisi S, Ess A, Alaluusua S, et al. : Amoxicillin May Cause Molar Incisor Hypomineralization. J Dent Res, 88:132-136, 2009. https://doi.org/10.1177/0022034508328334
  33. Prashanth S, Seema D : Missing links of Molar Incisor Hypomineralization: A review. J Int Oral Health, 4:1-11, 2012.
  34. Roggini M, Pepino D, Capocaccia P, et al. : Respiratory distress in newborn: evaluation of chest X-rays. Minerva Pediatr, 62:217-219, 2010.
  35. Suckling G, Elliott DC, Thurley DC : The production of developmental defects of enamel in the incisor teeth of penned sheep resulting from induced parasitism. Arch Oral Biol, 28:393-399, 1983. https://doi.org/10.1016/0003-9969(83)90134-6
  36. Fearne JM, Elliott JC, Jones SJ, et al. : Deciduous enamel defects in low-birthweight children: correlated X-ray microtomographic and backscattered electron imaging study of hypoplasia and hypomineralization. Anat Embryol, 189:375-381, 1994.
  37. Beentjes VE, Weerheijm KL, Groen HJ : Factors involved in the aetiology of molar incisor hypomineralization (MIH). Eur Arch Paediatr Dent, 3:9-13, 2002.
  38. Tung K, Fujita H, Yamashita Y, Takagi Y : Effect of turpentine-induced fever during the enamel formation of rat incisor. Arch Oral Biol, 51:464-470, 2006. https://doi.org/10.1016/j.archoralbio.2005.12.001
  39. Kwon BM, Bae IH, Jeong TS, et al. : Dental caries status of 14-16 year old adolescents in Yangsan area. J Korean Acad Pediatr Dent, 41:8-16, 2014. https://doi.org/10.5933/JKAPD.2014.41.1.8
  40. Cho SH, Lee HS, Choi HG, et al. : Correlation between caries expierience and new colorimetric caries activity test in children. J Korean Acad Pediatr Dent, 42:30-37, 2015. https://doi.org/10.5933/JKAPD.2015.42.1.30