Journal of the korean academy of Pediatric Dentistry (대한소아치과학회지)

Korean Academy of Pediatric Dentistry (대한소아치과학회)
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Evaluation of Remineralization Effects on Enamel Demineralization by Anti-cariogenic Agents using Quantitative Light-induced Fluorescence-digital (QLF-D) in vitro

유치 및 영구치에서 QLF를 이용한 항우식 제품의 재광화 효과 비교

  • Lee, Kkotnim (Division of Pediatric Dentistry, Department of Dentistry, Ewha Womans University Mokdong Hospital) ;
  • Kim, Miae (Division of Pediatric Dentistry, Department of Dentistry, Ewha Womans University Mokdong Hospital) ;
  • Hwang, Inkyung (Division of Pediatric Dentistry, Department of Dentistry, Ewha Womans University Mokdong Hospital) ;
  • Park, Jihyun (Division of Pediatric Dentistry, Department of Dentistry, Ewha Womans University Mokdong Hospital) ;
  • Mah, Yonjoo (Division of Pediatric Dentistry, Department of Dentistry, Ewha Womans University Mokdong Hospital)
  • 이꽃님 (이화여자대학교 의과대학 목동병원 소아치과학교실) ;
  • 김미애 (이화여자대학교 의과대학 목동병원 소아치과학교실) ;
  • 황인경 (이화여자대학교 의과대학 목동병원 소아치과학교실) ;
  • 박지현 (이화여자대학교 의과대학 목동병원 소아치과학교실) ;
  • 마연주 (이화여자대학교 의과대학 목동병원 소아치과학교실)
  • Received : 2016.02.01
  • Accepted : 2016.03.25
  • Published : 2016.11.30
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Abstract

The purpose of this study was to evaluate the difference of remineralization effects of various anti-cariogenic toothpastes on artificial carious lesions in primary and permanent teeth using quantitative light-induced fluorescence-digital (QLF-D) system. Sound human primary (n = 48) and permanent teeth (n = 48) were randomly divided into following groups : control group (Group 1), fluoride toothpaste (Group 2), functionalized tricalcium phosphate (fTCP) + fluoride toothpaste (Group 3), and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) toothpaste (Group 4). Specimens were prepared by exposure in a demineralizing solution and then treated using the different toothpastes twice daily during 14 days. All specimens were analyzed with the QLF-D system. QLF data analysis indicated three different toothpastes showed significant remineralizing effects compared to Group 1 in both primary and permanent teeth. Also, the remineralizing effects in Group 3 and 4 were significantly higher than in Group 2. This study suggested that the toothpastes containing fTCP + fluoride and CPP-ACP have the significant anti-cariogenic effects on enamel demineralization in both primary and permanent teeth, and QLF-D is an useful device to assess the incipient carious lesion and remineralization effects of the anti-cariogenic materials quantitatively. Therefore, clinicians can consider the QLF-D system for the evaluation of demineralization and remineralization in primary and permanent teeth.

본 연구의 목적은 quantitative light-induced fluorescence-digital(QLF-D) 시스템을 이용하여 유치와 영구치에 형성된 탈회된 법랑질에 서로 다른 세 종류의 항우식 제품 적용 후 각각의 재광화 효과를 비교하는 데 있다. 연구를 위해 각 48개의 건전한 유치 및 영구치를 대상으로 대조군(1군), 불소 함유 치약(2군), functionalized tricalcium phosphate(fTCP) + 불소 함유 치약(3군), casein phosphopeptide-amorphous calcium phosphate(CPP-ACP) 함유 치아 크림(4군)으로 무작위 분류하였다. 유치 및 영구치에 법랑질 탈회를 유발한 후, 14일 동안 1일 2회 항우식 제품을 처리하였으며, quantitative light-induced fluorescence(QLF)를 이용하여 재광화 효과를 비교 분석하였다. 연구 결과, 세 종류의 항우식 제품 모두 유치와 영구치에서 대조군인 1군에 비해 우식 병소의 무기질 소실량을 유의하게 감소시켰으며, 치약 제품 간 비교에서는 3군과 4군에서 2군에 비해 유의하게 높은 재광화 효과를 나타냈다. 이를 통하여 fTCP와 불소 함유 치약 및 CPP-ACP 함유치아 크림이 유치와 영구치 모두에서 우수한 재광화 효과를 보인다는 것과, QLF-D가 초기 우식 병소와 항우식 제제의 재광화 효과를 정량적으로 평가함에 있어 유용한 장비임을 알 수 있다. 그러므로 임상가들은 유치와 영구치에서의 탈회 및 재광화 평가 시 QLF-D 시스템의 임상적 적용을 고려할 수 있을 것이다.

Keywords

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