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Cellmed Orthocellular Medicine and Pharmaceutical Association (셀메드 세포교정의약학회)
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Biological effects of zinc oxide nanoparticles on inflammation

  • Kim, Min-Ho (Department of Computer Aided Mechanical Engineering, Sohae College)
  • Received : 2016.05.01
  • Accepted : 2016.11.18
  • Published : 2016.11.30
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Abstract

With the rapid developments in nanotechnology, an increasing number of nanomaterials have been applied in various aspects of our lives. Recently, pharmaceutical nanotechnology with numerous advantages has growingly attracted the attention of many researchers. Zinc oxide nanoparticles (ZnO-NPs) are nanomaterials that are widely used in many fields including diagnostics, therapeutics, drug-delivery systems, electronics, cosmetics, sunscreens, coatings, ceramic products, paints, and food additives, due to their magnetic, catalytic, semiconducting, anti-cancer, anti-bacterial, anti-inflammatory, ultraviolet-protective, and binding properties. The present review focused on the recent research works concerning role of ZnO-NP on inflammation. Several studies have reported that ZnO-NP induces inflammatory reaction through the generation of reactive oxygen species by oxidative stress and production of inflammatory cytokines by activation of nuclear factor-${\kappa}B$ ($NF-{\kappa}B$). Meanwhile, other researchers reported that ZnO-NP exhibits an anti-inflammatory effect by inhibiting the up-regulation of inflammatory cytokines and the activation of $NF-{\kappa}B$, caspase-1, $I{\kappa}B$ $kinase{\beta}$, receptor interacting protein2, and extracellular signal-regulated kinase. Previous studies reported that size and shape of nanoparticles, surfactants used for nanoparticles protection, medium, and experimental conditions can also affect cellular signal pathway. This review indicated that the anti-inflammatory effectiveness of ZnO-NP was determined by the nanoparticle size as well as various experimental conditions. Therefore, the author suggests that pharmaceutical therapy with the ZnO-NP is one of the possible strategies to overcome the inflammatory reactions. However, further studies should be performed to maximize the anti-inflammatory effect of ZnO-NP to apply as a potential agent in biomedical applications.

Keywords

References

  1. Andoh T, Nagasawa T, Satoh M, Kuraishi Y. Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J Pharmacol Exp Ther. 1998;286:1140-1145.
  2. Babin K, Goncalves DM, Girard D. Nanoparticles enhance the ability of human neutrophils to exert phagocytosis by a Sykdependent mechanism. Biochim Biophys Acta. 2015;1850:2276-2282. https://doi.org/10.1016/j.bbagen.2015.08.006
  3. Barton GM. A calculated response: control of inflammation by the innate immune system. J Clin Invest. 2008;118:413-420. https://doi.org/10.1172/JCI34431
  4. Chang H, Ho CC, Yang CS, Chang WH, Tsai MH, Tsai HT, Lin P. Involvement of MyD88 in zinc oxide nanoparticle-induced lung inflammation. Exp Toxicol Pathol. 2013;65:887-896. https://doi.org/10.1016/j.etp.2013.01.001
  5. Chiang HM, Xia Q, Zou X, Wang C, Wang S, Miller BJ, Howard PC, Yin JJ, Beland FA, Yu H, Fu PP. Nanoscale ZnO induces cytotoxicity and DNA damage in human cell lines and rat primary neuronal cells. J Nanosci Nanotechnol. 2012;12:2126-2135. https://doi.org/10.1166/jnn.2012.5758
  6. Contado C. Nanomaterials in consumer products: a challenging analytical problem. Front Chem. 2015;3:48.
  7. Dizaj SM, Lotfipour F, Barzegar-Jalali M, Zarrintan MH, Adibkia K. Antimicrobial activity of the metals and metal oxide nanoparticles. Mater Sci Eng C Mater Biol Appl. 2014;44:278-284. https://doi.org/10.1016/j.msec.2014.08.031
  8. Frederickson CJ, Hernan-dez MD, Goik SA, Morton JD, McGinty JF. Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures: a histofluorescence study. Brain Res. 1988;446:383-386. https://doi.org/10.1016/0006-8993(88)90899-2
  9. Frederickson CJ, Koh JY, Bush AI. The neurobiology of zinc in health and disease. Nat Rev Neurosci. 2005;6:449-462. https://doi.org/10.1038/nrn1671
  10. Fukui H, Iwahashi H, Endoh S, Nishio K, Yoshida Y, Hagihara Y, Horie M. Ascorbic acid attenuates acute pulmonary oxidative stress and inflammation caused by zinc oxide nanoparticles. J Occup Health. 2015;57:118-125. https://doi.org/10.1539/joh.14-0161-OA
  11. Giovanni M, Yue J, Zhang L, Xie J, Ong CN, Leong DT. Pro-inflammatory responses of RAW264.7 macrophages when treated with ultralow concentrations of silver, titanium dioxide, and zinc oxide nanoparticles. J Hazard Mater. 2015;297:146-152. https://doi.org/10.1016/j.jhazmat.2015.04.081
  12. Hackenberg S, Scherzed A, Technau A, Kessler M, Froelich K, Ginzkey C, Koehler C, Burghartz M, Hagen R, Kleinsasser N. Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro. Toxicol In Vitro. 2011;25:657-663. https://doi.org/10.1016/j.tiv.2011.01.003
  13. Harhaj EW, Dixit VM. Deubiquitinases in the regulation of NF-${\kappa}$B signaling. Cell Res. 2011;21:22-39. https://doi.org/10.1038/cr.2010.166
  14. Higgs GA, Moncada S, Vane JR. Eicosanoids in inflammation. Ann Clin Res. 1984;16:287-299.
  15. Horie M, Stowe M, Tabei M, Kuroda E. Pharyngeal aspiration of metal oxide nanoparticles showed potential of allergy aggravation effect to inhaled ovalbumin. Inhal Toxicol. 2015;27:181-190. https://doi.org/10.3109/08958378.2015.1026618
  16. Huang KL, Lee YH, Chen HI, Liao HS, Chiang BL, Cheng TJ. Zinc oxide nanoparticles induce eosinophilic airway inflammation in mice. J Hazard Mater. 2015;297:304-312. https://doi.org/10.1016/j.jhazmat.2015.05.023
  17. Ilves M, Palomaki J, Vippola M, Lehto M, Savolainen K, Savinko T, Alenius H. Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model. Part Fibre Toxicol. 2014;11:38. https://doi.org/10.1186/s12989-014-0038-4
  18. Jansen J, Karges W, Rink L. Zinc and diabetes--clinical links and molecular mechanisms. J Nutr Biochem. 2009;20:399-417. https://doi.org/10.1016/j.jnutbio.2009.01.009
  19. Jeong HJ, Koo HN, Na HJ, Kim MS, Hong SH, Eom JW, Kim KS, Shin TY, Kim HM. Inhibition of TNF-alpha and IL-6 production by Aucubin through blockade of NF-kappaB activation RBL-2H3 mast cells. Cytokine. 2002;18:252-259. https://doi.org/10.1006/cyto.2002.0894
  20. Jeong SH, Kim HJ, Ryu HJ, Ryu WI, Park YH, Bae HC, Jang YS, Son SW. ZnO nanoparticles induce TNF-${\alpha}$ expression via ROS-ERK-Egr-1 pathway in human keratinocytes. J Dermatol Sci. 2013;72:263-273. https://doi.org/10.1016/j.jdermsci.2013.08.002
  21. Kim MH, Jeong HJ. Zinc oxide nanoparticels demoted MDM2 expression to suppress TSLP-induced mast cell proliferation. J Nanosci Nanotechnol. 2016;16:2492-2498. https://doi.org/10.1166/jnn.2016.10785
  22. Kim MH, Jeong HJ. Zinc Oxide Nanoparticles Suppress LPS-Induced NF-${\kappa}$B Activation by Inducing A20, a Negative Regulator of NF-${\kappa}$B, in RAW 264.7 Macrophages. J Nanosci Nanotechnol. 2015;15:6509-6515. https://doi.org/10.1166/jnn.2015.10319
  23. Kim MH, Seo JH, Kim HM, Jeong HJ. Zinc oxide nanoparticles, a novel candidate for the treatment of allergic inflammatory diseases. Eur J Pharmacol. 2014;738:31-39. https://doi.org/10.1016/j.ejphar.2014.05.030
  24. Kumar R, Clermont G, Vodovotz Y, Chow CC. "The dynamics of acute inflammation". J Theor Biol. 2004;230:145-155. https://doi.org/10.1016/j.jtbi.2004.04.044
  25. Kumar V, Cotran RS. Robbins SL. Robbins Basic Pathology. 18th ed. (Philadelphia, USA: Saunders), 2003.
  26. Kwon DJ, Ju SM, Youn GS, Choi SY, Park J. Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-${\kappa}$B and AP-1 activation in RAW 264.7 macrophages. Food Chem Toxicol. 2013;58:479-486. https://doi.org/10.1016/j.fct.2013.05.031
  27. Li CH, Liao PL, Shyu MK, Liu CW, Kao CC, Huang SH, Cheng YW, Kang JJ. Zinc oxide nanoparticles-induced intercellular adhesion molecule 1 expression requires Rac1/Cdc42, mixed lineage kinase 3, and c-Jun N-terminal kinase activation in endothelial cells. Toxicol Sci. 2012;126:162-172. https://doi.org/10.1093/toxsci/kfr331
  28. Liu J, Feng X, Wei L, Chen L, Song B, Shao L. The toxicology of ion-shedding zinc oxide nanoparticles. Crit Rev Toxicol. 2016;46:348-384. https://doi.org/10.3109/10408444.2015.1137864
  29. Majno G, Joris I. Cells, Tissues, and Disease. 2nd ed. (Oxford, UK: Oxford University Press), 2004.
  30. Maremanda KP, Khan S, Jena G. Zinc protects cyclophosphamide-induced testicular damage in rat: Involvement of metallothionein, tesmin and Nrf2. Biochem Biophys Res Commun. 2014;445:591-596. https://doi.org/10.1016/j.bbrc.2014.02.055
  31. Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454:24:428-435.
  32. Nakanishi W, Minami K, Shrestha LK, Ji Q, Hill JP, Ariga K. Bioactive nanocarbon assemblies: Nanoarchitectonics and applications. Nano Today. 2014;9:378-394. https://doi.org/10.1016/j.nantod.2014.05.002
  33. Pati R, Mehta RK, Mohanty S, Padhi A, Sengupta M, Vaseeharan B, Goswami C, Sonawane A. Topical application of zinc oxide nanoparticles reduces bacterial skin infection in mice and exhibits antibacterial activity by inducing oxidative stress response and cell membrane disintegration in macrophages. Nanomedicine. 2014;10:1195-1208. https://doi.org/10.1016/j.nano.2014.02.012
  34. Perkins ND. Integrating cell-signalling pathways with NF-${\kappa}$B and IKK function. Nat Rev Mol Cell Biol. 2007;8:49-62. https://doi.org/10.1038/nrm2083
  35. Roy R, Kumar S, Verma AK, Sharma A, Chaudhari BP, Tripathi A, Das M, Dwivedi PD. Zinc oxide nanoparticles provide an adjuvant effect to ovalbumin via a Th2 response in Balb/c mice. Int Immunol. 2014;26:159-172. https://doi.org/10.1093/intimm/dxt053
  36. Roy R, Parashar V, Chauhan LK, Shanker R, Das M, Tripathi A, Dwivedi PD. Mechanism of uptake of ZnO nanoparticles and inflammatory responses in macrophages require PI3K mediated MAPKs signaling. Toxicol In Vitro. 2013;28:457-467.
  37. Roy R, Parashar V, Chauhan LK, Shanker R, Das M, Tripathi A, Dwivedi PD. Mechanism of uptake of ZnO nanoparticles and inflammatory responses in macrophages require PI3K mediated MAPKs signaling. Toxicol In Vitro. 2014;28:457-467. https://doi.org/10.1016/j.tiv.2013.12.004
  38. Seabra AB, Haddad P, Duran N. Biogenic synthesis of nanostructured iron compounds: applications and perspectives. IET Nanobiotechnol. 2013;7:90-99. https://doi.org/10.1049/iet-nbt.2012.0047
  39. Senapati VA, Kumar A, Gupta GS, Pandey AK, Dhawan A. ZnO nanoparticles induced inflammatory response and genotoxicity in human blood cells: A mechanistic approach. Food Chem Toxicol. 2015;85:61-70. https://doi.org/10.1016/j.fct.2015.06.018
  40. Shapiro SD, Campbell EJ, Welgus HG, Senior RM. Elastin degradation by mononuclear phagocytes. Ann N Y Acad Sci. 1991;624:69-80. https://doi.org/10.1111/j.1749-6632.1991.tb17007.x
  41. Sharma V, Singh P, Pandey AK, Dhawan A. Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles. Mutat Res. 2012;745:84-91. https://doi.org/10.1016/j.mrgentox.2011.12.009
  42. Shembade N, Ma A, Harhaj EW. Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science. 2010;327:1135-1139. https://doi.org/10.1126/science.1182364
  43. Skjot-Arkil H, Barascuk N, Register T, Karsdal MA. Macrophage-mediated proteolytic remodeling of the extracellular matrix in atherosclerosis results in neoepitopes: a potential new class of biochemical markers. Assay Drug Dev Technol. 2010;8:542-552. https://doi.org/10.1089/adt.2009.0258
  44. Song YH, Nam SY, Choi YJ, Kim JH, Kim YS, Jeong HJ. Socioeconomic impact traditional Korean medicine, Pyeongwee-San (KMP6) as an anti-allergic inflammatory drug. TANG. 2002;2:e29.
  45. Spencer LA, Szela CT, Perez SA, Kirchhoffer CL, Neves JS, Radke AL, Weller PF. Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially. J Leukoc Biol. 2009;85:117-123.
  46. Stoehr LC, Endes C, Radauer-Preiml I, Boyles MS, Casals E, Balog S, Pesch M, Petri-Fink A, Rothen-Rutishauser B, Himly M, Clift MJ, Duschl A. Assessment of a panel of interleukin-8 reporter lung epithelial cell lines to monitor the proinflammatory response following zinc oxide nanoparticle exposure under different cell culture conditions. Part Fibre Toxicol. 2015;12:29. https://doi.org/10.1186/s12989-015-0104-6
  47. Stone SF, Isbister GK, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, Ariaratnam A, Jacoby-Alner TE, Cotterell CL, Brown SG. Immune response to snake envenoming and treatment with antivenom; complement activation, cytokine production and mast cell degranulation. PLoS Negl Trop Dis. 2013;7:e2326. https://doi.org/10.1371/journal.pntd.0002326
  48. Taniguchi N. On the Basic Concept of 'Nano-Technology'. In Proceedings of the International Conference on Production Engineering, Tokyo, PartII. (Tokyo, Japan: Japan Society of Precision Engineering), 1974.
  49. Tornatore L, Thotakura AK, Bennett J, Moretti M, Franzoso G. The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation. Trends Cell Biol. 2012;22:557-566. https://doi.org/10.1016/j.tcb.2012.08.001
  50. Tsou TC, Yeh SC, Tsai FY, Lin HJ, Cheng TJ, Chao HR, Tai LA. Zinc oxide particles induce inflammatory responses in vascular endothelial cells via NF-${\kappa}$B signaling. J Hazard Mater. 2010;183:182-188. https://doi.org/10.1016/j.jhazmat.2010.07.010
  51. Wahab R, Kim YS, Mishra A, Yun SI, Shin HS. Formation of ZnO Micro-Flowers Prepared via Solution Process and their Antibacterial Activity. Nanoscale Res Lett. 2010;5:1675-1681. https://doi.org/10.1007/s11671-010-9694-y
  52. Wahab R, Siddiqui MA, Saquib Q, Dwivedi S, Ahmad J, Musarrat J, Al-Khedhairy AA, Shin HS. ZnO nanoparticles induced oxidative stress and apoptosis in HepG2 and MCF-7 cancer cell and their antibacterial activity. Colloids Surf B Biointerfaces. 2014;117:267-276. https://doi.org/10.1016/j.colsurfb.2014.02.038
  53. Whatmore RW. "Nanotechnology--what is it? Should we be worried?" Occupational Medicine. 2006;56:295-299. https://doi.org/10.1093/occmed/kql050

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