Archives of Plastic Surgery

  • 제43권6호
  • /
  • Pages.498-505
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  • 2016
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  • 2234-6163(pISSN)
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  • 2234-6171(eISSN)
대한성형외과학회 (Korean Society of Plastic and Reconstructive Surgeons)
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Comparison of Saccharina japonica-Undaria pinnatifida Mixture and Minoxidil on Hair Growth Promoting Effect in Mice

  • Park, Ki Soo (Department of Plastic and Reconstructive Surgery, Daegu Catholic University Medical Center, Catholic University of Daegu School of Medicine) ;
  • Park, Dae Hwan (Department of Plastic and Reconstructive Surgery, Daegu Catholic University Medical Center, Catholic University of Daegu School of Medicine)
  • 투고 : 2016.01.29
  • 심사 : 2016.09.13
  • 발행 : 2016.11.18
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초록

Background Algae have traditionally been used for promotion of hair growth. Use of hair regrowth drugs, such as minoxidil, is limited due to side effects. The aim of this study was to examine a mixture of Saccharina japonica and Undaria pinnatifida (L-U mixture) on hair growth and to compare the promoting effect of hair growth by a 3% minoxidil and a L-U mixture. Methods To evaluate the hair growth-promoting activity, saline, 50% ethanol, 3% minoxidil, and the L-U mixture were applied 2 times a day for a total of 14 days on the dorsal skin of C57BL/6 mice after depilation. Analysis was determined by using a high-resolution hair analysis system, real-time polymerase chain reaction, and H&E staining. Results On day 14, the hair growth effect of the L-U mixture was the same as that of the 3% minoxidil treatment. The L-U mixture significantly (P<0.05) stimulated hair growth-promoting genes, as vascular endothelial growth factor (VEGF) and insulin-like growth factor -1. Increase of VEGF was observed in the L-U mixture group compared with minoxidil and the negative control. In contrast, the L-U mixture suppressed the expression of transforming growth factor-${\beta}1$, which is the hair loss-related gene. In histological examination in the L-U mixture and minoxidil groups, the induction of an anagen stage of hair follicles was faster than that of control groups. Conclusions This study provides evidence that the L-U mixture can promote hair growth in mice, similar to the effect from minoxidil, and suggests that there is potential application for hair loss treatments.

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참고문헌

  1. Ambrosio GB. Minoxidil in resistant hypertension. Lancet 1977;2:1087.
  2. Paus R. Therapeutic strategies for treating hair loss. Drug Discov Today Ther Strat 2006;3:101-10. https://doi.org/10.1016/j.ddstr.2006.03.004
  3. Price VH, Menefee E. Quantitative estimation of hair growth. I. androgenetic alopecia in women: effect of minoxidil. J Invest Dermatol 1990;95:683-7. https://doi.org/10.1111/1523-1747.ep12514348
  4. Cotsarelis G, Millar SE. Towards a molecular understanding of hair loss and its treatment. Trends Mol Med 2001;7:293-301. https://doi.org/10.1016/S1471-4914(01)02027-5
  5. Danilenko DM, Ring BD, Pierce GF. Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy. Mol Med Today 1996;2:460-7. https://doi.org/10.1016/1357-4310(96)10045-9
  6. Philpott MP, Sanders DA, Kealey T. Effects of insulin and insulin-like growth factors on cultured human hair follicles: IGF-I at physiologic concentrations is an important regulator of hair follicle growth in vitro. J Invest Dermatol 1994;102:857-61. https://doi.org/10.1111/1523-1747.ep12382494
  7. McElwee KJ, Huth A, Kissling S, et al. Macrophage-stimulating protein promotes hair growth ex vivo and induces anagen from telogen stage hair follicles in vivo. J Invest Dermatol 2004;123:34-40. https://doi.org/10.1111/j.0022-202X.2004.22712.x
  8. Kang JI, Kim EJ, Kim MK, et al. The promoting effect of Ishige sinicola on hair growth. Mar Drugs 2013;11:1783-99. https://doi.org/10.3390/md11061783
  9. Kang JI, Kim SC, Han SC, et al. Hair-Loss Preventing effect of Grateloupia elliptica. Biomol Ther (Seoul) 2012;20:118-24. https://doi.org/10.4062/biomolther.2012.20.1.118
  10. Bak SS, Ahn BN, Kim JA, et al. Ecklonia cava promotes hair growth. Clin Exp Dermatol 2013;38:904-10. https://doi.org/10.1111/ced.12120
  11. Cho JY, Kang JY, Khan MN, et al. Anti-inflammatory activities of Undaria pinnatifida and Laminaria japonica (Phaeophyta). J Fish Sci Technol 2007;10:127-32.
  12. Ha WH, Park DH. Effect of seaweed extract on hair growth promotion in experimental study of C57BL/6 mice. Arch Craniofac Surg 2013;14:1-10. https://doi.org/10.7181/acfs.2013.14.1.1
  13. Hirata N, Tokunaga M, Naruto S, et al. Testosterone 5alpha-reductase inhibitory active constituents of Piper nigrum leaf. Biol Pharm Bull 2007;30:2402-5. https://doi.org/10.1248/bpb.30.2402
  14. Junlatat J, Sripanidkulchai B. Hair growth-promoting effect of Carthamus tinctorius floret extract. Phytother Res 2014;28:1030-6. https://doi.org/10.1002/ptr.5100
  15. Kumar N, Rungseevijitprapa W, Narkkhong NA, et al. 5alpha-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment. J Ethnopharmacol 2012;139:765-71. https://doi.org/10.1016/j.jep.2011.12.010
  16. Jung HA, Oh SH, Choi JS. Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity. Bioorg Med Chem Lett 2010;20:3211-5. https://doi.org/10.1016/j.bmcl.2010.04.093
  17. Bae SJ, Choi YH. Methanol extract of the seaweed Gloiopeltis furcata induces G2/M arrest and inhibits cyclooxygenase-2 activity in human hepatocarcinoma HepG2 cells. Phytother Res 2007;21:52-7. https://doi.org/10.1002/ptr.2020
  18. Khan MN, Yoon SJ, Choi JS, et al. Anti-edema effects of brown seaweed (Undaria pinnatifida) extract on phorbol 12-myristate 13-acetate-induced mouse ear inflammation. Am J Chin Med 2009;37:373-81. https://doi.org/10.1142/S0192415X09006837
  19. Leonard SG, Sweeney T, Bahar B, et al. Effect of maternal seaweed extract supplementation on suckling piglet growth, humoral immunity, selected microflora, and immune response after an ex vivo lipopolysaccharide challenge. J Anim Sci 2012;90:505-14. https://doi.org/10.2527/jas.2010-3243
  20. Yang JH. Topical application of fucoidan improves atopic dermatitis symptoms in NC/Nga mice. Phytother Res 2012;26:1898-903. https://doi.org/10.1002/ptr.4658
  21. Kimura J, Maki N. New loliolide derivatives from the brown alga Undaria pinnatifida. J Nat Prod 2002;65:57-8. https://doi.org/10.1021/np0103057
  22. Yang X, Kang MC, Lee KW, et al. Antioxidant activity and cell protective effect of loliolide isolated from Sargassum ringgoldianum subsp. coreanum. Algae 2011;26:201-8. https://doi.org/10.4490/algae.2011.26.2.201
  23. Hibino T, Nishiyama T. Role of TGF-beta2 in the human hair cycle. J Dermatol Sci 2004;35:9-18. https://doi.org/10.1016/j.jdermsci.2003.12.003
  24. Zhang D, Lijuan G, Jingjie L, et al. Cow placenta extract promotes murine hair growth through enhancing the insulin - like growth factor-1. Indian J Dermatol 2011;56:14-8. https://doi.org/10.4103/0019-5154.77544

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  2. Do Kimchi and Cheonggukjang Probiotics as a Functional Food Improve Androgenetic Alopecia? A Clinical Pilot Study vol.38, pp.1, 2016, https://doi.org/10.5534/wjmh.180119
  3. Algae as an attractive source for cosmetics to counter environmental stress vol.772, pp.None, 2016, https://doi.org/10.1016/j.scitotenv.2020.144905