Korean journal of food and cookery science (한국식품조리과학회지)

Korean Society of Food and Cookery Science (한국식품조리과학회)
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Effects of Gastrodiae rhizoma on the Liver Function and Alcohol Metabolism in Alcohol Treated Rats

천마 추출물이 알코올을 투여한 흰쥐의 간 기능 및 알코올 대사에 미치는 영향

  • Park, Soon-Ja (Department of Herbal Food Science, Graduate School of Daegu Haany University) ;
  • Kang, Ju-Hyeon (Department of Herbal Food Science, Graduate School of Daegu Haany University) ;
  • Kong, Hyun-Joo (Faculty of Herbal Food Cuisine and Nutrition, Daegu Haany University) ;
  • Hwang, Su-Jung (Faculty of Herbal Food Cuisine and Nutrition, Daegu Haany University) ;
  • Jang, Jung-Hyeon (Division of Cosmetology, Dong-Eui Institute of Technology) ;
  • Yang, Kyung-Mi (Faculty of Herbal Food Cuisine and Nutrition, Daegu Haany University)
  • 박순자 (대구한의대학교 대학원 한방식품학과) ;
  • 강주현 (대구한의대학교 대학원 한방식품학과) ;
  • 공현주 (대구한의대학교 한방식품조리영양학부) ;
  • 황수정 (대구한의대학교 한방식품조리영양학부) ;
  • 장정현 (부산동의과학대학교 피부미용계열) ;
  • 양경미 (대구한의대학교 한방식품조리영양학부)
  • Received : 2016.11.14
  • Accepted : 2016.11.22
  • Published : 2016.12.31
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Abstract

Purpose: This study was conducted to investigate the effect of freeze-dried Gastrodiae rhizoma powder (GR) on the liver function and alcohol metabolism in alcohol treated rats. Methods: The rats were administered various concentrations of GR (100 mg, 200 mg, 300 mg/kg B.W.) for 3 days 1 hour before 50% (v/v) ethanol (3 g/kg B.W.) administration. Two tests focusing on liver function and alcohol metabolism in acute alcohol treatment were carried out. Results: Glutamic oxaloacetic transaminase activity was significantly increased by alcohol treatment, and was decreased by 100 mg GR administration. Acute ethanol treatment led to significant increase in alcohol and acetaldehyde levels of serum and liver. However, 100 mg GR administration led to a significant reduction in increased alcohol level in the serum with decreased alcohol dehydrogenase (ADH) activity and increased acetaldehyde level in liver was significantly reduced by three levels. Conclusion: These results suggest that GR can be effective in enhancing liver function and alcohol metabolism in the alcohol-treated rats. Studies on the appropriate dosage of GR should further be developed to treat alcohol detoxification and stimulate liver function.

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References

  1. Choi GH, Kim JG, Kwon ST. 2011. Protective effects of food including Hovenia dulcis on acute alcohol intoxication. J Korean Soc Food Sci Nutr 40(8):1107-1112. https://doi.org/10.3746/jkfn.2011.40.8.1107
  2. Chung YI, Bae IY, Lee JY, Chun HS, Lee HG. 2009. Protective effects of branched-chain amino acid (BCAA)-enriched corn gluten hydrolysates on ethanol-induced hepatic injury in rats. Korean J Food Sci Technol 41(6):706-711.
  3. Das SK, Vasudevan DM. 2007. Alcohol-induced oxidative stress. Life Sci 81(3):177-187. https://doi.org/10.1016/j.lfs.2007.05.005
  4. Gill K, Amit Z, Smith BR. 1996. The regulation of alcohol consumption in rats: The role of alcohol-metabolizing enzymes-catalase and aldehyde dehydrogenase. Alcohol 13(4):347-353. https://doi.org/10.1016/0741-8329(96)00006-7
  5. Han CK, Seong KS, Lee KW, Park SS, Jeong JY, Kim SS. 2014. Effects of Omija (Schizandra chinesis Baillon) concentrate on blood alcohol clearance and hepatoprotective function in rats induced by acute ethanol intoxication and chronic ethanol treatment. J Korean Soc Food Sci Nutr 43(8):1139-1147. https://doi.org/10.3746/jkfn.2014.43.8.1139
  6. Hong HD, Shim EJ, Kim KI, Choi SY, Han CK. 2007. Effect of Gastrodiae elata blume components on systolic blood pressure and serum lipid concentrations in spontaneously hypertensive rats fed high fat diet. J Korean Soc Food Sci Nutr 36(2):174-179. https://doi.org/10.3746/jkfn.2007.36.2.174
  7. Hwang SJ, Choi HM, Park HJ, Lee JS, Heo D, Kim MR. 2010. Effects of medicinal herbal drink on alcohol metabolic enzyme in drunken rats. Korean J Orient Physiol Pathol 24(4):610-615.
  8. Jeon TW, Lee ES, Lee YS, Han OK, Bae JC, Kim KJ, Kim HJ. 2002. Eliminatory effect of mixed extract of Hovenia Dulcis Thunb and Gastrodia Elata on ethanol-induced hangover in rats. Korean J Orient Physiol Pathol 16(5):905-910.
  9. Jo YO, Koo SJ, Choi IS, Kong YH, Choi SY. 2007. Effects of Camellia sinesis extracts on the antioxidant system and alcohol down-regulation enzymes in sub-acute ethanol treated ICR mice. J Korean Soc Food Sci Nutr 36(9):1134-1139. https://doi.org/10.3746/jkfn.2007.36.9.1134
  10. Jung BS. 1991. Metabolic effects of alcohol. Korean J Food Nutr 4(2):207-211.
  11. Jung HK, Park CD, Hwang MH, Park SC, Kim DI, Hong JH. 2008. Characteristics of alcohol metabolism of Hahyangju in rats. Korean J Food Preserv 15(1):155-160.
  12. Keshavarzian A, Fields JZ, Vaeth J, Holmes EW. 1994. The differing effects of acute and chronic alcohol on gastric and intestinal permeability. Amer J Gastroenterol 89(12): 2205-2211.
  13. Kim HJ, Kwon OJ, Lee AR, Roh SS, Seo YB. 2016. Protective effects of Gastrodia rhizoma and steamed & fermented Gastrodiae rhizoma with anti-oxidant efficacy and suppression of NFkB signaling pathway on LPS-induced liver injury. J Appl Biol Chem 59(3):179-188. https://doi.org/10.3839/jabc.2016.033
  14. Kim IH. 2008. Pathophysiology of alcoholic liver disease. Clin Mole Hepatol 14(4s):7-21.
  15. Kim JM, Park JH, Kim MK, Chun HS. 2008. Effects of Paecilomyces tenuipes water extract on the alcohol metabolism of rats. J Korean Soc Food Sci Nutr 37(3):396-400. https://doi.org/10.3746/jkfn.2008.37.3.396
  16. Kim KI, Han CK, Seong KS, Lee OH, Park JM, Lee BY. 2003. Effect of whole powder and extracts of Gastrodiae rhizoma on serum lipids and body fat in rats fed high-fat diet. Korean J Food Sci Technol 35(4):720-725.
  17. Kim MK, Nam KS, So MS, Shon YH. 2013. The effect of deep sea water containing low molecular weight chitosan on alcohol metabolism. J Chitin Chitosan 18(2):81-86.
  18. Kim YH, Seo BI. 2012. A phiological study on poisoning and side effects of Gastrodiae Rhizoma (天麻). J Jeanhan Orient Med Acad 10(1):137-145.
  19. Ko BS, Jang JS, Hong SM, Kim DW, Sung SR, Park HR, Lee JE, Jeon WK, Park SM. 2006. Effect of new remedies mainly compaired of Hovenia dulcis Thunb on alcohol degradation and liver protection in Sprague Dawley male rats. J Korean Soc Food Sci Nutr 35(7):828-834. https://doi.org/10.3746/jkfn.2006.35.7.828
  20. Kwon HJ, Kim HS, Choi YH, Choi JH, Choi HS, Song J, Park SY. 2014. Antioxidant activity and quality characteristics on the maturation period of the soy sauce with Gastrodia elata and oak mushroom (Lentinus edodes). Korean J Food Preserv 21(2):231-238. https://doi.org/10.11002/kjfp.2014.21.2.231
  21. Kwon YO. 2003. Therapy and perspectives of alcoholic liver disease. Clin Mole Hepatol 9(1s):36-45.
  22. Lands WE. 1998. A review of alcohol clearance in humans. Alcohol 15(2):147-160. https://doi.org/10.1016/S0741-8329(97)00110-9
  23. Lee HI, Seo KI, Lee J, Lee JS, Hong SM, Lee JH, Kim MJ, Lee MK. 2011. Effect of fermented cucumber beverage on ethanol metabolism and antioxidant activity in ethanoltreated rats. J Korean Soc Food Nutr 40(8):1099-1106. https://doi.org/10.3746/jkfn.2011.40.8.1099
  24. Lee SY, Kim SK, Kwon CI, Kim MJ, Kang MS, Ko KH, Hong SP, Hwang SG, Park PW, Rim KS. 2008. Clinical characteristics of health screen examines with nonalcoholic fatty liver and normal function test. Korean J Gastroenterol 52(3):161-170.
  25. Lieber CS, Decarli LM. 1991. Hepatotoxicity of ethanol. J Hepatol 12(3):394-401. https://doi.org/10.1016/0168-8278(91)90846-4
  26. Lieber CS, Gentry RT, Haraona E. 1994. First pass metabolism of ethanol. Alcohol Alcohol 2(Suppl):163-169.
  27. Lieber CS. 1993. Aetiology and pathogenesis of alcoholic liver disease. Bailliere's Clin Gasroenterol 7(3):581-608. https://doi.org/10.1016/0950-3528(93)90003-B
  28. Lieber CS. 2004. Alcoholic fatty liver: Its pathogenesis and metabolism of progression to inflammation and fibrosis. Alcohol 34(1):9-19. https://doi.org/10.1016/j.alcohol.2004.07.008
  29. Morris R. 1984. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Method 11(1):47-60. https://doi.org/10.1016/0165-0270(84)90007-4
  30. Noh KH, Jang JH, Kim JJ, Shin JH, Kim DK, Song YS. 2009. Effect of dandelion juice supplementation on alcoholinduced oxidative stress and hangover in health male college students. J Korean Soc Food Sci Nutr 38(6):683-693. https://doi.org/10.3746/jkfn.2009.38.6.683
  31. Park PS, Park MY. 2001. Effects of Dioscorea batatas and Gastrodia rhizoma on fatty acid compositions of serum, liver and brain in rats. Korean J Life Sci 11(1):83-92.
  32. Park SH, Shin MK, Han JH. 2005. Study on the Gastrodiae rhizoma as applications in Yacksun (medicated diets) for preventing of cerebral cardiovascular disease. (1) Effects of Gastrodiae rhizoma on the regional cerebral blood flow and blood pressure. J East Asian Soc Diet Life 15(3): 283-291.
  33. Park SH, Yoon HK, Koo SJ. 2004. Effects of water extracts of Camelia sinensis LINNE on blood alcohol concentration and activities of acute alcohol metabolic enzymes in ICR mouse. J East Asian Soc Diet Life 14(6):634-639.
  34. Shim EJ. 2006. Effects of Gastrodiae rhizoma fractions on hepatic alcohol metabolic enzyme system in rats. Master's thesis. Seoul Women's University, Seoul, Korea. pp 34-57.
  35. Son JC, Kim SH, Lee SI, Lee YK, Kim SD. 2012. Effect of ethanol extracts of Youngia denticulata and Youngia sonchifolia on the serum and hepatic lipids and activities of ethanol metabolizing enzymes in acute ethanol-treated rats. J Korean Soc Food Sci Nutr 41(2):197-204. https://doi.org/10.3746/jkfn.2012.41.2.197
  36. Tsukamoto H, Towner SJ, Clofalo LM, French SW. 1986. Ethanol-induced liver fibrosis in rats fed high fat diet. Hepatol 6(5):814-822. https://doi.org/10.1002/hep.1840060503
  37. Vidal F, Todar R, Gutierrez C, Broach M, Fernandez-Muixi F, Lorenzo A, Richart C. 1998. Influence of chronic alcohol abuse and liver disease on hepatic aldehyde dehydrogenase activity. Alcohol 15(1):3-8. https://doi.org/10.1016/S0741-8329(97)00073-6
  38. Wall TL, Peterson CM, Peterson KP, Johnson ML, Thomasson HR, Cole M, Ehlers CL. 1997. Alcohol metabolism in Asian-American men with genetic polymorphisms of aldehyde dehydrogenase. Ann Intern Med 127(5):376-379. https://doi.org/10.7326/0003-4819-127-5-199709010-00007
  39. Yang KM. 2008. The effects of Gastrodiae rhizoma powder on plasma lipids profiles in the elderly with cardiovascular disease. J Korean Soc Food Sci Nutr 37(7):858-868. https://doi.org/10.3746/jkfn.2008.37.7.858