Journal of Radiation Protection and Research

The Korean Association for Radiation Protection (대한방사선방어학회)
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Examination History and Abnormal Thyroid and Breast Lesions According to Residential Distance from Nuclear Power Plants

  • Lim, Young-Khi (Department of Radiological Science, Gachon University)
  • Received : 2016.09.20
  • Accepted : 2016.10.20
  • Published : 2016.12.31
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Abstract

Background: Ascertainment bias are common in epidemiologic studies to assess the association between thyroid cancer risk and living near nuclear power plants because many thyroid cancers are diagnosed by chance through health examination. We surveyed the ultra sonography (USG) examination history and conducted thyroid and breast USG in residents living near nuclear power plants. Materials and Methods: The study population comprised 2,421 residents living near nuclear power plants in Korea. Information on demographic characteristics, including diagnostic examination history, was collected by interview using questionnaires. USG examination was conducted to evaluate the presence of thyroid nodules and breast lesion. Study participants were divided into 3 groups according to the distance of their respective villages from a nuclear power plant. The proportions of USG examination history and prevalence of thyroid nodules and breast lesions were compared between groups. Results and Discussion: Examination histories of thyroid USG were 23.1%, 13.7%, and 10.5% in men and 31.3%, 26.7%, 18.3% in women in the short, intermediate, and long distance groups, respectively. There were significant inverse associations between thyroid USG history and the distance from nuclear power plants (P for trend = 0.001 for men and 0.017 for women). However, there was no association between the distance of villages from nuclear power plants and prevalence of thyroid nodules. Conclusion: Our results suggest that there may be an ascertainment bias in population-based studies examining the harmful effects of NPPs examination and researchers should pay attention to ascertainment bias resulted from differential health examination. Correction for ascertainment bias, active follow-up and examination for all study population to remove differential health examination is needed.

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References

  1. Brent GA, Braverman LE, Zoeller RT. Thyroid health and the environment. Thyroid 2007;17:807-809. https://doi.org/10.1089/thy.2007.1514
  2. Richardson DB. Exposure to ionizing radiation in adulthood and thyroid cancer incidence. Epidemiology 2009;20:181-187. https://doi.org/10.1097/EDE.0b013e318196ac1c
  3. Brenner AV, et al. 131I dose response for incident thyroid cancers in Ukraine related to the Chornobyl accident. Environ. Health Perspect. 2011;119:933-939. https://doi.org/10.1289/ehp.1002674
  4. Zablotska LB, et al. Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident. Br. J. Cancer. 2011;104:181-187. https://doi.org/10.1038/sj.bjc.6605967
  5. Wang SI, Yaung CL, Lee LT, Chiou SJ. Cancer incidence in the vicinity of nuclear power plants in Taiwan: a population-based study. Environ. Sci. Pollut. Res. Int. 2016;23(1):571-580. https://doi.org/10.1007/s11356-015-5289-6
  6. Ahn YO, et al. Cancer risk in adult residents near nuclear power plants in Korea-a cohort study of 1992-2010. J. Korean Med. Sci. 2012;27:999-1008. https://doi.org/10.3346/jkms.2012.27.9.999
  7. Kim JM, Kim MH, Ju YS, Hwang SS, Ha M, Paek D. Re: cancer risk in adult residents near nuclear power plants in Korea: a cohort study of 1992-2010. J. Korean Med. Sci. 2014;29:1436-1437. https://doi.org/10.3346/jkms.2014.29.10.1436
  8. Lee WJ. Cancer risk among population near nuclear power plants in Korea. J. Korean Med. Sci. 2015;30:666-667. https://doi.org/10.3346/jkms.2015.30.5.666
  9. Oh CM, Won YJ, Jung KW, Kong HJ, Lee JK, Lee DH, Lee KH. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2013. Cancer Res. Treat. 2016;48(2):436-45. https://doi.org/10.4143/crt.2016.089
  10. Ahn HS, Kim HJ, Welch HG. Korea's thyroid-cancer "epidemic"-screening and overdiagnosis. N. Engl. J. Med. 2014;371:1765-1767. https://doi.org/10.1056/NEJMp1409841
  11. Cardis E, et al. Risk of thyroid cancer after exposure to 131I in childhood. J. Natl. Cancer Inst. 2005;97:724-732. https://doi.org/10.1093/jnci/dji129
  12. Tronko MD, et al. A cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: thyroid cancer in Ukraine detected during first screening. J. Natl. Cancer Inst. 2006;98:897-903. https://doi.org/10.1093/jnci/djj244
  13. Bleuer JP, Averkin YI, Okeanov AE, Abelin T. The epidemiological situation of thyroid cancer in Belarus. Stem Cells. 1997;15 Suppl. 2:251-254.
  14. Bunch KJ, Vincent TJ, Black RJ, Pearce MS, McNally RJ, McKinney PA, Parker L, Craft AW, Murphy MF. Updated investigations of cancer excesses in individuals born or resident in the vicinity of Sellafield and Dounreay. Br. J. Cancer. 2014;111:1814-1823. https://doi.org/10.1038/bjc.2014.357
  15. Wanigaratne S, Holowaty E, Jiang H, Norwood TA, Pietrusiak MA, Brown P. Estimating cancer risk in relation to tritium exposure from routine operation of a nuclear-generating station in Pickering, Ontario. Chron. Dis. Inj. Can. 2013;33:247-256.
  16. Kim J, Bang Y, Lee WJ. Living near nuclear power plants and thyroid cancer risk: A systematic review and meta-analysis. Environ. Int. 2016;87:42-48. https://doi.org/10.1016/j.envint.2015.11.006
  17. National Research Council. Analysis of cancer risks in populations near nuclear facilities: phase I. National Research Council; 2012;148-174.
  18. Xing M. BRAF mutation in thyroid cancer. Endocr. Relat. Cancer. 2005;12:245-262. https://doi.org/10.1677/erc.1.0978
  19. Kondo T, Ezzat S, Asa SL. Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nat. Rev. Cancer. 2006;6:292-306. https://doi.org/10.1038/nrc1836
  20. Dal Maso L, Bosetti C, La Vecchia C, Franceschi S. Risk factors for thyroid cancer: an epidemiological review focused on nutritional factors. Cancer Causes & Control. 2009;20:75-86. https://doi.org/10.1007/s10552-008-9219-5
  21. Han MA, Choi KS, Lee HY, Kim Y, Jun JK, Park EC. Current status of thyroid cancer screening in Korea: results from a nationwide interview survey. Asian Pac. J. Cancer Prev. 2011;12:1657-1663.
  22. Chung JH. Unfounded reports on thyroid cancer. J. Korean Med. Sci. 2014;29:1033-1034. https://doi.org/10.3346/jkms.2014.29.8.1033
  23. Choi SW, Ryu SY, Han MA, Park J. The association between the socioeconomic status and thyroid cancer prevalence; based on the Korean national health and nutrition examination survey 2010-2011. J. Korean Med. Sci. 2013;28:1734-1740. https://doi.org/10.3346/jkms.2013.28.12.1734