Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Advancing Risk Assessment through the Application of Systems Toxicology

  • Sauer, John Michael (Predictive Safety Testing Consortium, Critical Path Institute) ;
  • Kleensang, Andre (Johns Hopkins University, Center for Alternatives to Animal Testing (CAAT), Bloomberg School of Public Health) ;
  • Peitsch, Manuel C. (PMI Research and Development) ;
  • Hayes, A. Wallace (Harvard University and Michigan State University Institute for Integrative Toxicology)
  • Received : 2015.12.02
  • Accepted : 2016.01.13
  • Published : 2016.01.15
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Abstract

Risk assessment is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. Mechanistic approaches to risk assessment have been generally referred to as systems toxicology. Systems toxicology makes use of advanced analytical and computational tools to integrate classical toxicology and quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Three presentations including two case studies involving both in vitro and in vivo approaches described the current state of systems toxicology and the potential for its future application in chemical risk assessment.

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References

  1. Sauer, J.M., Hartung, T., Leist, M., Knudsen, T.B., Hoeng, J. and Hayes, A.W. (2015) Systems toxicology: the future of risk assessment. Int. J. Toxicol., 34, 346-348. https://doi.org/10.1177/1091581815576551
  2. Hartung, T., van Vliet, E., Jaworska, J., Bonilla, L., Skinner, N. and Thomas, R. (2012) Systems toxicology. Altex, 29, 119-128. https://doi.org/10.14573/altex.2012.2.119
  3. Sturla, S.J., Boobis, A.R., FitzGerald, R.E., Hoeng, J., Kavlock, R.J., Schirmer, K., Whelan, M., Wilks, M.F. and Peitsch, M.C. (2014) Systems toxicology: from basic research to risk assessment. Chem. Res. Toxicol., 27, 314-329. https://doi.org/10.1021/tx400410s
  4. Miller, R.M., Callahan, L.M., Casaceli, C., Chen, L., Kiser, G.L., Chui, B., Kaysser-Kranich, T.M., Sendera, T.J., Palaniappan, C. and Federoff, H.J. (2004) Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra. J. Neurosci., 24, 7445-7454. https://doi.org/10.1523/JNEUROSCI.4204-03.2004

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