Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Attenuating effect of Lactobacillus brevis G101 on the MSG symptom complex in a double-blind, placebo-controlled study

  • Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University) ;
  • Choi, Yeji (Department of Food and Nutrition, Kyung Hee University) ;
  • Park, Sun-Sung (Department of Food and Nutrition, Kyung Hee University) ;
  • Kim, Se-Young (R & D center, CTCBIO Inc.) ;
  • Han, Myung Joo (Department of Food and Nutrition, Kyung Hee University)
  • Received : 2015.01.09
  • Accepted : 2015.09.09
  • Published : 2015.12.01
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Abstract

BACKGROUND/OBJECTIVES: Lactobacillus brevis G101 suppresses the absorption of monosodium glutamate (MSG) from the intestine into the blood in mice. Therefore, the attenuating effect of orally administered G101 on monosodium glutamate (MSG) symptom complex was investigated in humans MATERIALS/METHODS: Capsules (300 mg) containing Lactobacillus brevis G101 ($1{\times}10^{10}CFU/individual$) or maltodextrin (placebo) was orally administered in 30 respondents with self-recognized monosodium glutamate (MSG) symptom complex for 5 days and the rice with black soybean sauce containing 6 g MSG (RBSM) was ingested 30 min after the final administration. Thereafter, the MSG symptom complex (rated on a 5-point scale: 1, none; 5, strong) was investigated in a double blind placebo controlled study. The intensity of the MSG symptom complex was significantly reduced in respondents of the G101 intake group ($2.87{\pm}0.73$) compared to that in those treated with the placebo ($3.63{\pm}1.03$) (P = 0.0016). Respondents in the placebo group exhibited more of the various major conditions of the MSG symptom complex than in the G101 intake group. Although there was no significant difference in the appearance time of the MSG symptom complex between subjects orally administered G101 and those administered the placebo, its disappearance in < 3 h was observed in 69.9% of subjects in the G101 treatment group and in 38.0% of subjects in the placebo group (P = 0.0841). CONCLUSIONS: Oral administration of Lactobacillus brevis G101 may be able to reduce the intensity of the MSG symptom complex.

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References

  1. Geha RS, Beiser A, Ren C, Patterson R, Greenberger PA, Grammer LC, Ditto AM, Harris KE, Shaughnessy MA, Yarnold PR, Corren J, Saxon A. Review of alleged reaction to monosodium glutamate and outcome of a multicenter double-blind placebo-controlled study. J Nutr 2000;130:1058S-1062S. https://doi.org/10.1093/jn/130.4.1058S
  2. Yaqub H, Abdel Baky NA, Attia HA, Faggah LM. Hepatoprotective effect of N-acetyl cysteine and/or beta-carotene on monosodium glutamate-induced toxicity in rats. Res J Med Med Sci 2008;3:206-15.
  3. Xiong JS, Branigan D, Li M. Deciphering the MSG controversy. Int J Clin Exp Med 2009;2:329-36.
  4. Bellisle F. Glutamate and the UMAMI taste: sensory, metabolic, nutritional and behavioural considerations. A review of the literature published in the last 10 years. Neurosci Biobehav Rev 1999;23:423-38. https://doi.org/10.1016/S0149-7634(98)00043-8
  5. Kwok RH. Chinese-restaurant syndrome. N Engl J Med 1968;278:796.
  6. Meadows M. MSG. A common flavor enhancer. FDA Consum 2003;37:34-5.
  7. Yang WH, Drouin MA, Herbert M, Mao Y, Karsh J. The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomized study. J Allergy Clin Immunol 1997;99:757-62. https://doi.org/10.1016/S0091-6749(97)80008-5
  8. Kanmani P, Satish Kumar R, Yuvaraj N, Paari KA, Pattukumar V, Arul V. Probiotics and its functionally valuable products-a review. Crit Rev Food Sci Nutr 2013;53:641-58. https://doi.org/10.1080/10408398.2011.553752
  9. Gomes AM, Malcata FX. Bifidobacterium spp. and Lactobacillus acidophilus: biological, biochemical, technological and therapeutical properties relevant for use as probiotics. Trends Food Sci Technol 1999;10:139-57. https://doi.org/10.1016/S0924-2244(99)00033-3
  10. Cho YR, Chang JY, Chang HC. Production of gamma-aminobutyric acid (GABA) by Lactobacillus buchneri isolated from kimchi and its neuroprotective effect on neuronal cells. J Microbiol Biotechnol 2007;17:104-9.
  11. Tamura T, Noda M, Ozaki M, Maruyama M, Matoba Y, Kumagai T, Sugiyama M. Establishment of an efficient fermentation system of gamma-aminobutyric acid by a lactic acid bacterium, Enterococcus avium G-15, isolated from carrot leaves. Biol Pharm Bull 2010;33:1673-9. https://doi.org/10.1248/bpb.33.1673
  12. Cherubini E, Gaiarsa JL, Ben-Ari Y. GABA: an excitatory transmitter in early postnatal life. Trends Neurosci 1991;14:515-9. https://doi.org/10.1016/0166-2236(91)90003-D
  13. Jang SE, Han MJ, Kim SY, Kim DH. Lactobacillus brevis G101 inhibits the absorption of monosodium glutamate in mice. J Microbiol Biotechnol 2014;24:1592-6. https://doi.org/10.4014/jmb.1310.10125
  14. Jang SE, Hyam SR, Han MJ, Kim SY, Lee BG, Kim DH. Lactobacillus brevis G-101 ameliorates colitis in mice by inhibiting $NF-{\kappa}B$, MAPK and AKT pathways and by polarizing M1 macrophages to M2-like macrophages. J Appl Microbiol 2013;115:888-96. https://doi.org/10.1111/jam.12273
  15. Schaumburg HH, Byck R, Gerstl R, Mashman JH. Monosodium L-glutamate: its pharmacology and role in the Chinese restaurant syndrome. Science 1969;163:826-8. https://doi.org/10.1126/science.163.3869.826

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