Journal of Acupuncture Research

  • 제32권3호
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  • Pages.127-133
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  • 2015
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  • 2586-288X(pISSN)
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  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
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첨가물에 의한 봉독의 안정화 및 안전성

Stability and Safety of Bee Venom with and without Additives

  • 배영현 (강남자생한방병원 침구의학과) ;
  • 이종환 (강남자생한방병원 침구의학과) ;
  • 김해솔 (강남자생한방병원 침구의학과) ;
  • 김호선 (강남자생한방병원 침구의학과) ;
  • 서창용 (강남자생한방병원 침구의학과) ;
  • 김노현 (강남자생한방병원 침구의학과) ;
  • 이진호 (자생척추관절연구소 자생의료재단) ;
  • 하인혁 (자생척추관절연구소 자생의료재단) ;
  • 김미령 (자생척추관절연구소 자생의료재단) ;
  • 정화진 (자생척추관절연구소 자생의료재단) ;
  • 이인희 (자생척추관절연구소 자생의료재단) ;
  • 김민정 (자생척추관절연구소 자생의료재단) ;
  • 김은지 (자생척추관절연구소 자생의료재단) ;
  • 이재웅 (자생척추관절연구소 자생의료재단)
  • Bae, Young Hyeon (Department of Acupuncture and Moxibustion of Korean Medicine, Gangnam Jaseng Korean Medicine Hospital) ;
  • Lee, Chong Hwan (Department of Acupuncture and Moxibustion of Korean Medicine, Gangnam Jaseng Korean Medicine Hospital) ;
  • Kim, Hae Sol (Department of Acupuncture and Moxibustion of Korean Medicine, Gangnam Jaseng Korean Medicine Hospital) ;
  • Kim, Ho Sun (Department of Acupuncture and Moxibustion of Korean Medicine, Gangnam Jaseng Korean Medicine Hospital) ;
  • Suh, Chang Yong (Department of Acupuncture and Moxibustion of Korean Medicine, Gangnam Jaseng Korean Medicine Hospital) ;
  • Kim, No Hyeon (Department of Acupuncture and Moxibustion of Korean Medicine, Gangnam Jaseng Korean Medicine Hospital) ;
  • Lee, Jin Ho (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Ha, In Hyuk (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Kim, Me Riong (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Chung, Hwa Jin (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Lee, In Hee (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Kim, Min Jeong (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Kim, Eun Jee (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Lee, Jae Woong (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation)
  • 투고 : 2015.08.20
  • 심사 : 2015.09.02
  • 발행 : 2015.09.20
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초록

Objectives : Previous studies have shown that the amount of melittin, the main active ingredient in bee venom pharmacopuncture, tends to decrease substantially with time during pharmacopuncture manufacture. This study aimed to assess whether the stability of bee venom pharmacopuncture improved with pharmacopuncture additives. Methods : Components were measured using high performance liquid chromatography. Acute toxicity and antigenicity tests by subcutaneous and venous routes were conducted at Korea Pharmaceutical Test & Research Institute and mortality, adverse reactions, and body weight changes were assessed. Results : Stability tests using additives revealed that bee venom without additives was most stable. Bee venom pharmacopuncture without additives was further tested for toxicity in subcutaneous and venous administration in mice and no changes pertaining to toxicity were found over the testing period. Conclusions : Bee venom pharmacopuncture without additives was found to be most stable, and further, it did not show toxicity or antigenicity in subcutaneous and venous administration in mice.

키워드

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