Journal of Acupuncture Research

  • 제32권3호
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  • Pages.83-93
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  • 2015
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  • 2586-288X(pISSN)
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  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
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Effects of Acupuncture at SP6 on Reflux Esophagitis in Rats

  • Lee, Yun Kyu (Department of Acupuncture & Moxibustion, Meridian & Acupoint, College of Korean Medicine, Deagu Haany University) ;
  • Rho, Sung Soo (Department of Herbology, College of Korean Medicine, Deagu Haany University) ;
  • Kim, Jae Soo (Department of Acupuncture & Moxibustion, Meridian & Acupoint, College of Korean Medicine, Deagu Haany University)
  • 투고 : 2015.08.07
  • 심사 : 2015.08.24
  • 발행 : 2015.09.20
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초록

Objectives : The purpose of this study was to evaluate whether acupuncture at $SP_6$ attenuates esophageal inflammation on refluxed-induced esophagitis. Methods : Acupuncture at $SP_6$ was stimulated by acupuncture torsion technique for 30 seconds four times every hour after an operation induced reflux esophagitis(RE), and its effects were assessed in comparison with RE rats without acupuncture, and normal rats. Results : $SP_6$ acupuncture stimulation markedly ameliorated mucosal damage in the histological evaluation. Reflux-induced esophagitis rats exhibited the down-regulation of antioxidant-related protein expression levels such as heme oxygenase-1(HO-1) in the esophagitis; however, the associated levels with $SP_6$ acupuncture stimulation were significantly higher than those in RE rats without acupuncture stimulation. Moreover, $SP_6$ acupuncture stimulation significantly reduced the expression of inflammatory proteins through mitogen-activated protein kinase(MAPK)-related signaling pathways. The increased protein expressions of inflammatory mediators, cyclooxygenase-2(COX-2) and inducible nitric oxide synthase(iNOS), by nuclear factor-kappa B(NF-kB) activation were significantly suppressed through $SP_6$ acupuncture stimulation. Conclusions : Our findings support the therapeutic evidence for $SP_6$ acupuncture stimulation alleviating the development of esophagitis via regulating inflammation through the activation of the antioxidant pathway.

키워드

참고문헌

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