Journal of Acupuncture Research

  • 제32권3호
  • /
  • Pages.1-13
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  • 2015
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  • 2586-288X(pISSN)
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  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
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Sweet 봉약침과 저준위 레이저침이 Complete Freund's Adjuvant로 유발된 관절염 백서 모델에 미치는 영향

Effects of Sweet Bee Venom Pharmacopuncture and Low Level Laser Acupuncture on a Rat Model with Complete Freund's Adjuvant-induced Arthritis

  • 이정훈 (동신대학교 한의과대학 침구의학교실) ;
  • 김경옥 (동신대학교 한의과대학 한방신경정신과학교실) ;
  • 김경수 (동신대학교 한의과대학) ;
  • 박수연 (동신대학교 한의과대학 한방안이비인후피부과학교실) ;
  • 양승정 (동신대학교 한의과대학 한방부인과학교실) ;
  • 최창원 (동신대학교 한의과대학 한방내과학교실) ;
  • 나창수 (동신대학교 한의과대학 경혈학교실) ;
  • 위통순 (동신대학교 한의과대학 침구의학교실)
  • Lee, Jung Hun (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongshin University) ;
  • Kim, Kyeong Ok (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Dongshin University) ;
  • Kim, Kyeong Su (College of Oriental Medicine, Dongshin University) ;
  • Park, Soo Yeon (Department of Oriental Opthalmology, Otolaryngology & Dermatology, College of Oriental Medicine, Dongshin University) ;
  • Yang, Seung Joung (Department of Oriental Gynecology, College of Oriental Medicine, Dongshin University) ;
  • Choi, Chang Won (Department of Oriental Internal Medicine, College of Oriental Medicine, Dongshin University) ;
  • Na, Chang Su (Department of Acupoint & Meridian, College of Oriental Medicine, Dongshin University) ;
  • Wei, Tung Shuen (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongshin University)
  • 투고 : 2015.05.08
  • 심사 : 2015.09.02
  • 발행 : 2015.09.20
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초록

Purpose : This research was conducted to investigate the effect of sweet bee venom pharmacopuncture and low level laser acupuncture on paw edema, pain index, anti-inflammatory factor, AST, ALT and complete blood cell count of a rat model with Complete Freund's Adjuvant-induced arthritis. Methods : Five experimental groups were formed with each consisting of six rats: normal group, control group, sweet bee venom pharmacopuncture group, lower level laser acupuncture group, and sweet bee venom pharmacopuncture, lower level laser acupuncture group. The experimental model of arthritis was induced by two injections of Freund's adjuvant into the left knee joint of Sprague Dawley(SD) rats. The second injection of Freund's adjuvant was given ten days after the first one. Ten days later, sweet bee venom pharmacopuncture and low level laser acupuncture were administered separately or together by assigned groups at $GB_{34}$ and $GB_{39}$ of rats twice a week for a total of six times. Thereafter, edema rate, pain index, tumor necrosis factor-${\alpha}$, interleukin-6, aspartate aminortansferase, alanine aminotransferase and complete blood cell count were measured. Results : We noticed synergic effects of sweet bee venom pharmacopuncture and low level laser acupuncture according to the results of the paw edema and Von Frey pain index. The sweet bee venom pharmacopuncture(BVA) and sweet bee venom pharmacopuncture+ low level laser acupuncture(BVA+LLA) groups experienced a more significant effect when compared with the control group. Conclusions : These results suggest that Sweet Bee Venom Pharmacopuncture and low level laser acupuncture at GB34 and GB39 have a significant anti-inflammatory effect on Freund's adjuvant arthritis in rats.

키워드

참고문헌

  1. James B Wyngeeden. Cecil textbook of medicine. Philadelphia : WA Sauders Company. 1992 : 1508-15.
  2. Korean Acupuncture & Moxibustion Society Textbook Compilation Committee. The Acupuncture and Moxibustion. Gyeonggi : Jipmoondang. 2008 : 127.
  3. Ahn YG. A series of meridian point theory. Seoul : Sungbosa. 2000 : 584-5, 592-3.
  4. Korean Pharmacopuncture Institute. Pharmacopuncture. Seoul : Elsevier Korea LLC. 2008 : 167-9.
  5. Kim CW, Lee YH, Lee GH. The case report of an anaphylaxis occurred when using sweet bee venom and common bee venom at the same time. Journal of Pharmacopuncture. 2011 ; 14(4) : 59-61. https://doi.org/10.3831/KPI.2011.14.4.059
  6. Jang IS, Cho GH, Kim YS et al. Study on clinical application of low level laser therapy in oriental medicine by reviewing recent research. Journal of Korean Medicine. 2001 ; 22(3) : 11-20.
  7. Yook TH. Clinical observation of effects of He-Ne laser acupuncture on pain. The Acupuncture. 1997 ; 14(1) : 1-8.
  8. Kim GD, Kim GS, Ahn CB et al. Study on the effect of acupuncture, moxibustion and laser beam acupuncture upon the allviation of pain in mice. The Acupuncture. 1987 ; 4(1) : 39-48.
  9. Wei TS, Yoon DH, Yoon YC et al. Comparative study of acupuncture and invasive laser acupuncture therapy at SI3 BL40 on the tibial, sural nerve injury and L5 spinal nerve ligation model in rats. J Kor AM-M&P Soc. 2005 ; 22(2) : 9-24.
  10. Nah SY. Effects of low level laser on pain and cartilage regeneration for a rat model with degenerative arthritis. Naju : Dongshin University. 2012. Korean.
  11. Kim YS, Lee JH, Lee SH et al. Effects of electro acupuncture and low level laser theraphy at GB39 and GB34 on neuropathic pain in rats induced by tibial and sural nerves ligation. The Acupuncture. 2013 ; 30(3) : 125-34. https://doi.org/10.13045/acupunct.2013012
  12. Han TR, Bang MS. Rehabilitation nedication. Seoul : Goonja Publisher. 2008 : 908.
  13. Bae SC. Mechanics and causes of rheumarthritis. Journal of the Korean Medical Association. 2010 ; 53(10) : 843-52. https://doi.org/10.5124/jkma.2010.53.10.843
  14. Koh EM. Medical treatment of rheumatoid arthritis (I): Nonsteroidal anti-inflammatory drugs, disease modifying antirheumatic drugs and glucocorticoids. Journal of the Korean Medical Association. 2010 ; 53(1) : 871-9. https://doi.org/10.5124/jkma.2010.53.10.871
  15. Hong WS. Junggyo Hwangjaenagyong Somoon. Seoul : Oriental Medicine Research Center. 1981 : 39-41.
  16. Jang JK. Jingguiyaolue. Taiwan : Daeryungulpung Company. 1973 : 32-3.
  17. Jang GA. Gyongakjunseo. Seoul : Jungdam Publisher. 1999 : 217.
  18. Kim DH, Jung SH, Seo IB et al. Inhibiting effects of Hwallak-dan on the adjuvant-induced arthritis in Lewis rats. JORM. 2011 ; 21(1) : 79-95.
  19. Ryu MS, Yoon YC, Kim JH. The effect of Angelica gigas NAKAI pharmacopuncture at ST36 and BL23 on Freund's adjuvant arthritis in rats. The Acupuncture. 2010 ; 27(5) : 25-34.
  20. Doh WS, Kim GS. The effect of aqua-acupuncture(Ulmi Pumilae, Ramulus Cinnamomum, Radix Achyranthis, Apitoxin, OK) on LPS-induced arthritis in mice. The Journal of The Korea Institute of Oriental Medicine Informatics. 1998 ; 4(1) : 81-93.
  21. Ahn HJ, Doh WS, Jang JH et al. Effects of acupuncture on rats with LPS-induced arthritis: focusing on macrophage, NK-cell, ICAM. The Journal of the Korea Institute of Oriental Medicine Informatics. 1998 ; 4(1) : 35-48.
  22. Song US, Ahn BC, Park DS. Studies of Ga-miso- pung-whal tang aqua-acupuncture treatment on the adjuvant arthritis induced by Freunds adjuvant complete. 1990. The Acupuncture. 1990 ; 7(1) : 19-37.
  23. Nah CS, Kim JS, Gwon OS et al. Comparison of effects of acupuncture with bear gall bladder, cow bezoar and bee venom. The Acupuncture. 1999 ; 16(1) : 533-47.
  24. Lee HS, Lee JD, Goh HG. The review on the study of bee venom in the domestic papers. The Acupuncture. 2003 ; 20(3) : 154-65.
  25. Yoon HM, Ahn CB, Cho EJ. An investigation of directions of research on bee venom in the sphere of oriental medicine in Korea in last decade. Dong-eui-han-eui-yeon. 2001 ; 5 : 23-42.
  26. Lee SH, Lee HJ, Paek YH et al. Effects of bee venom on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis patients. The Acupuncture. 2003 ; 20(2) : 77-84.
  27. Hwang YJ, Lee GM, Hwang WJ et al. Clinical research of bee venom Acupuncture effects on rheumatoid arthritis. The Acupuncture. 2001 ; 18(5) : 33-42.
  28. Kim TW, Choi DY, Lee JD. The effect of bee venom on type 2 collagen-induced arthritis. The Acupuncture. 2002 ; 19(2) : 92-104.
  29. Yoo DS, Yeom SR, Lee SG et al. The effect of bee venom pharmacopuncture therapy with concentrated treatment condition in rheumatoid arthritis rat model. JORM. 2011 ; 21(2) : 101-23.
  30. Lee SW, Kim YJ, Kim EJ et al. The effect of varying concentrations of bee venom pharmacoupuncture treatments on type ii collagen induced arthritis in mice. The Acupuncture. 2012 ; 29(1) : 75-87.
  31. Jan Tuner, Lars Hode. Laser treatment. Seoul : Jungdam. 2006 : 8-112.
  32. Kim JH, Huh W. Medical application of laser for ophthalmology. Journal of the Korean Medical Association. 1984 ; 27(2) : 103-12.
  33. Shir Y, Seltzer Z. Effects of sympathectomy in sciatic nerve injury in rats. Pain. 1991 ; 45(3) : 309-20. https://doi.org/10.1016/0304-3959(91)90056-4
  34. Lee GN. Clinical pathology file. Seoul : Eui- Hak-Moon-Hwa-Sa. 1990 : 82-7, 740-1.
  35. Lee GN. Lab test 2000 directory. Seoul : Goryeo Medicine. 1999 : 71-4.
  36. Scott D, Wolfe F, Huizinga TW, Rheumatoid arthritis. Lacet. 2010 ; 376(9746) : 1094-108.
  37. Park MH, Noh MH, Lee HW et al. The effects of swimming and low power laser on the concentration of interleukin-6 for rheumatoid arthritic rats. Physical Therapy Korea. 2008 ; 15(1) : 69-76.
  38. Murakawa Ueuji. Understanding of Internal Medicine with Pathophysiology. Seoul : Jungdam. 2008 : 71-89.
  39. Kwon Yl, Gang SC, Gang JS et al. Clinical pathology for experimental animals. Seoul : Academia. 2009 : 202, 207-10.