Journal of computational fluids engineering (한국전산유체공학회지)

Korean Society of Computational Fluids Engineering (한국전산유체공학회)
권호 표지
DOI QR코드

DOI QR Code

EVALUATION OF LAGRANGIAN AND EULERIAN APPROACHES FOR PREDICTION OF HEMOLYSIS IN BLOOD PUMPS

혈액펌프내 혈액 변성 예측에 대한 Lagrangian 및 Eulerian 기법의 평가

  • Hong, S. (Dept. of Mechanical Engineering, Graduate School, Sogang Univ.) ;
  • Son, C. (Dept. of Mechanical Engineering, Graduate School, Sogang Univ.) ;
  • Kang, S. (Multi-Phenomena CFD Engineering Research Center(ERC), Sogang Univ.) ;
  • Hur, N. (Multi-Phenomena CFD Engineering Research Center(ERC), Sogang Univ.) ;
  • Kim, W. (Multi-Phenomena CFD Engineering Research Center(ERC), Sogang Univ.) ;
  • Kang, S.H. (Dept. of Mechanical and Aerospace Engineering, Seoul National Univ.)
  • 홍성민 (서강대학교 대학원 기계공학과) ;
  • 손창근 (서강대학교 대학원 기계공학과) ;
  • 강성원 (서강대학교 다중현상 CFD 연구센터(ERC)) ;
  • 허남건 (서강대학교 다중현상 CFD 연구센터(ERC)) ;
  • 김원정 (서강대학교 다중현상 CFD 연구센터(ERC)) ;
  • 강신형 (서울대학교 기계항공공학부)
  • Received : 2015.07.26
  • Accepted : 2015.09.15
  • Published : 2015.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

A blood pump is an important part of a cardiac assist device. Since the shear rate in blood is known to be a primary factor on hemolysis generation, it has been very important to evaluate hemolysis inside blood pumps for understanding performance and reliability of cardiac assist devices. In this study, hemolysis generation inside blood pumps is analyzed using CFD with power-law based models for the blood damage index(BDI), in order to overcome difficulties in measuring hemolysis by experiment. The BDI values in blood pumps can be evaluated using Lagrangian or Eulerian approaches. In this study, several Lagrangian and Eulerian approaches are compared to estimate the efficiency of the numerical methods in a practice sense. It is found that the Eulerian approaches are advantageous in terms of the efficiency and robustness. Two different Eulerian approaches are used to evaluate the BDI values of a few commercial blood pumps. For the conditions of extracorporeal membrane oxygenator(ECMO) and ventricular assist device(VAD), local generation of hemolysis is analyzed using divided regions of blood pumps, in order to investigate the effects of the pump geometry.

Keywords

References

  1. 1997, ASTM Committee, Standard Practice for Assessment of Hemolysis in Continuous Flow Blood Pumps, Annual Book of ASTM Standards, F1941-97, Vol.13.01.
  2. 1965, Blackshear J., Perry L., Frank, D.D. and Joseph, H.S., "Some mechanical effects that influence hemolysis," ASAIO Journal, Vol.11, No.1, pp.112-117. https://doi.org/10.1097/00002480-196504000-00022
  3. 1980, Heuser, G. and Opitz, R.A., "Couette viscometer for short time shearing of blood," Biorheology, Vol.7, pp.17-24.
  4. 1990, Giersiepen, M., Wurzinger, L.J., Opitz, R. and Reul, H., "Estimation of shear stress-related blood damage in heart valve prostheses--in vitro comparison of 25 aortic valves," The International Journal of Artificial Organs, Vol.13, No.5, pp.300-306.
  5. 1972, Leverett, L.B., Hellums, J.D., Alfrey, C.P. and Lynch, E.C., "Red blood cell damage by shear stress," Biophysical Journal, Vol.12, No.3, pp.257-273. https://doi.org/10.1016/S0006-3495(72)86085-5
  6. 2012, Taskin, M.E., Fraser, K.H., Zhang, T., Wu, C., Griffith, B.P. and Wu, Z.J., "Evaluation of Eulerian and Lagrangian Models for Hemolysis Estimation," ASAIO Journal, Vol.58, No.4, pp.363-372. https://doi.org/10.1097/MAT.0b013e318254833b
  7. 2004, Johnston, B.M., Johnston, P.R., Corney, S. and Kilpatrick, D., "Non-Newtonian blood flow in human right coronary arteries: steady state simulations," Journal of Biomechanics, Vol.37, No.5, pp.709-720. https://doi.org/10.1016/j.jbiomech.2003.09.016
  8. 1991, Cho, Y.I. and Kensey, K.R., "Effects of the Non-Newtonian viscosity of blood on flows in a diseased arterial vessel. Part 1: Steady flows," Biorheology, Vol.28, pp.214-262.
  9. 2003, Song, X., Throckmorton, A.L., Wood, H.G., Antaki, J.F. and Olsen, D.B., "Computational Fluid Dynamics Prediction of Blood Damage in a Centrifugal Pump," Artificial Organs, Vol.27, No.10, pp.938-941. https://doi.org/10.1046/j.1525-1594.2003.00026.x
  10. 2003, Yano, T, Sekine, K., Mitoh, A., Mitamura, Y., Okamoto, E., Kim, D.W., Nishimura, I., Murabayashi, S. and Yozu, R., "An Estimation Method of Hemolysis within an Axial Flow Blood Pump by Computational Fluid Dynamics Analysis," Artificial Organs, Vol27, No.10, pp.920-925. https://doi.org/10.1046/j.1525-1594.2003.00034.x
  11. 2005, Grigioni, M., Morbiducci, U., D'Avenio, G., Di Benedetto, G. and Del Gaudio, C., "A Novel Formulation for Blood Trauma Prediction by a Modified Power-law Mathematical Model," Biomechanics and Modeling in Mechanobiology, Vol.4, No.4, pp.249-260. https://doi.org/10.1007/s10237-005-0005-y
  12. 2004, Garon, A. and Farinas, M.I., "Fast Three-dimensional Numerical Hemolysis Approximation.," Artificial Organs, Vol.28, No.11, pp.1016-1025. https://doi.org/10.1111/j.1525-1594.2004.00026.x
  13. 2015, Chang, M., Moshfeghi, M., Hur, N., Kang, S., Kim, W. and Kang, S.H., "Investigation on Mechanical and Bio-Mechanical Performance of a Centrifugal Blood Pump," Jounal of Computational Fluids Engineering, Vol.20, No.2, pp.88-95. https://doi.org/10.6112/kscfe.2015.20.2.088