Allergy, Asthma & Respiratory Disease

The Korean Academy of Asthma, Allergy and Clinical Immunology (대한천식알레르기학회)
권호 표지
DOI QR코드

DOI QR Code

Lack of associations between tumor necrosis factor-α genetic polymorphism-308G/A and antituberculous drug-induced maculopapular eruption

Tumor necrosis factor-alpha-308G/A의 유전적 다형성과 항결핵제 유발 반구진발진과의 연관성

  • Suh, Won Yong (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Kim, Yo Han (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Joo, Hyun Don (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Park, Seong Jun (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Ryuo, Sung Hyeok (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Choi, Ji Sung (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Ann, Sun Young (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Park, Chang Hyun (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Kim, Sang-Hoon (Department of Internal Medicine, Eulji University College of Medicine) ;
  • Kim, Sang-Heon (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Jee, Young-Koo (Department of Internal Medicine, Dankook University College of Medicine)
  • 서원용 (단국대학교 의과대학 내과학교실) ;
  • 김요한 (단국대학교 의과대학 내과학교실) ;
  • 주현돈 (단국대학교 의과대학 내과학교실) ;
  • 박성준 (단국대학교 의과대학 내과학교실) ;
  • 류성혁 (단국대학교 의과대학 내과학교실) ;
  • 최지성 (단국대학교 의과대학 내과학교실) ;
  • 안선영 (단국대학교 의과대학 내과학교실) ;
  • 박창현 (단국대학교 의과대학 내과학교실) ;
  • 김상훈 (을지대학교 의과대학 내과학교실) ;
  • 김상헌 (한양대학교 의과대학 내과학교실) ;
  • 지영구 (단국대학교 의과대학 내과학교실)
  • Published : 20150000
⟨ Previous Next ⟩

Abstract

Purpose: Adverse cutaneous reactions to antituberculous drugs (ATD), such as maculopapular eruption (MPE), are the most common causes of discontinuation of scheduled treatment of tuberculosis. We previously reported that tumor necrosis factor (TNF)-α genetic polymorphism -308G/A is significantly associated with ATD-induced hepatitis. This study aimed to investigate associations between TNF-α -308G/A and ATD-induced MPE. Methods: Patients with ATD-induced MPE and controls without any adverse reactions to ATD were recruited from the database of the Adverse Drug Reaction Pharmacogenomic Research Group database of Korea. We compared the genotype frequency of TNF-α -308G/A between patients with ATD-induced MPE and ATD-tolerant controls. Results: A total of 69 patients with ATD-induced MPE and 229 control subjects were enrolled for this study. There were no significant differences in genotype frequency between the patients and the controls, suggesting lack of associations between TNF-α -308G/A and ATD-induced MPE. Conclusion: The TNF-α genetic polymorphism -308G/A may not be related to the development of ATD-induced MPE, in contrast to ATD-induced hepatitis. These findings suggest that associations between TNF-α -308G/A and ATD-induced adverse reactions can be phenotype-specific.

Keywords

Acknowledgement

This research was supported by a grant of Korea Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), founded by the Ministry of Health & Welfare, Republic of Korea (grant No. HI14C0065).