Journal of Cardiovascular Imaging

  • 제23권1호
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  • Pages.1-7
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  • 2015
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  • 2586-7210(pISSN)
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  • 2586-7296(eISSN)
한국심초음파학회 (Korean Society of Echocardiography)
권호 표지
DOI QR코드

DOI QR Code

BICUSPID AORTIC VALVE: UNRESOLVED ISSUES AND ROLE OF IMAGING SPECIALISTS

  • SONG, JAE-KWAN (ASAN MEDICAL CENTER HEART INSTITUTE, UNIVERSITY OF ULSAN COLLEGE OF MEDICINE)
  • 투고 : 2014.12.03
  • 심사 : 2015.02.27
  • 발행 : 2015.03.27
⟨ 이전 논문 다음 논문 ⟩

초록

Bicuspid aortic valve (BAV) is the most common congenital heart disease with marked heterogeneity in many aspects. Fusion patterns of the aortic cusp are quite variable with different type and severity of valvular dysfunction. Moreover, non-valvular cardiovascular abnormalities are associated with BAV. Among them, aortic aneurysm/dissection is the most serious clinical condition with variable patterns of segmental aortic dilatation. Potential association between BAV phenotype and valvulopathy or aortopathy has been suggested, but needs to be tested further. A lack of long-term outcome data at this moment is responsible for unresolved debate regarding appropriate management of patients with BAV, specifically to prevent development of aortic dissection. Long-term follow-up data of a well-characterized cohort or registry based on standardized classification of BAV phenotype and aortopathy are necessary for evidence-based medical practice. Advanced imaging techniques such as computed tomography or magnetic resonance imaging offer better opportunities for accurate phenotype classification and imaging specialists should play a central role to establish a collaborative multicenter cohort or registry.

키워드

참고문헌

  1. Roberts WC. The congenitally bicuspid aortic valve. A study of 85 autopsy cases. Am J Cardiol 1970;26:72-83. https://doi.org/10.1016/0002-9149(70)90761-7
  2. Basso C, Boschello M, Perrone C, Mecenero A, Cera A, Bicego D, Thiene G, De Dominicis E. An echocardiographic survey of primary school children for bicuspid aortic valve. Am J Cardiol 2004;93:661-3. https://doi.org/10.1016/j.amjcard.2003.11.031
  3. Nistri S, Basso C, Marzari C, Mormino P, Thiene G. Frequency of bicuspid aortic valve in young male conscripts by echocardiogram. Am J Cardiol 2005;96:718-21. https://doi.org/10.1016/j.amjcard.2005.04.051
  4. Siu SC, Silversides CK. Bicuspid aortic valve disease. J Am Coll Cardiol 2010;55:2789-800. https://doi.org/10.1016/j.jacc.2009.12.068
  5. Michelena HI, Prakash SK, Della Corte A, Bissell MM, Anavekar N, Mathieu P, Bosse Y, Limongelli G, Bossone E, Benson DW, Lancellotti P, Isselbacher EM, Enriquez-Sarano M, Sundt TM 3rd, Pibarot P, Evangelista A, Milewicz DM, Body SC; BAVCon Investigators. Bicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon). Circulation 2014;129:2691-704. https://doi.org/10.1161/CIRCULATIONAHA.113.007851
  6. Schaefer BM, Lewin MB, Stout KK, Gill E, Prueitt A, Byers PH, Otto CM. The bicuspid aortic valve: an integrated phenotypic classification of leaflet morphology and aortic root shape. Heart 2008;94:1634-8. https://doi.org/10.1136/hrt.2007.132092
  7. Buchner S, Hülsmann M, Poschenrieder F, Hamer OW, Fellner C, Kobuch R, Feuerbach S, Riegger GA, Djavidani B, Luchner A, Debl K. Variable phenotypes of bicuspid aortic valve disease: classification by cardiovascular magnetic resonance. Heart 2010;96:1233-40. https://doi.org/10.1136/hrt.2009.186254
  8. Kang JW, Song HG, Yang DH, Baek S, Kim DH, Song JM, Kang DH, Lim TH, Song JK. Association between bicuspid aortic valve phenotype and patterns of valvular dysfunction and bicuspid aortopathy: comprehensive evaluation using MDCT and echocardiography. JACC Cardiovasc Imaging 2013;6:150-61. https://doi.org/10.1016/j.jcmg.2012.11.007
  9. Fernandez B, Duran AC, Fernandez-Gallego T, Fernandez MC, Such M, Arque JM, Sans-Coma V. Bicuspid aortic valves with different spatial orientations of the leaflets are distinct etiological entities. J Am Coll Cardiol 2009;54:2312-8. https://doi.org/10.1016/j.jacc.2009.07.044
  10. Fernandes SM, Sanders SP, Khairy P, Jenkins KJ, Gauvreau K, Lang P, Simonds H, Colan SD. Morphology of bicuspid aortic valve in children and adolescents. J Am Coll Cardiol 2004;44:1648-51. https://doi.org/10.1016/j.jacc.2004.05.063
  11. Fernandes SM, Khairy P, Sanders SP, Colan SD. Bicuspid aortic valve morphology and interventions in the young. J Am Coll Cardiol 2007;49:2211-4. https://doi.org/10.1016/j.jacc.2007.01.090
  12. Braverman AC. Aortic involvement in patients with a bicuspid aortic valve. Heart 2011;97:506-13. https://doi.org/10.1136/hrt.2009.183871
  13. Michelena HI, Khanna AD, Mahoney D, Margaryan E, Topilsky Y, Suri RM, Eidem B, Edwards WD, Sundt TM 3rd, Enriquez-Sarano M. Incidence of aortic complications in patients with bicuspid aortic valves. JAMA 2011;306:1104-12. https://doi.org/10.1001/jama.2011.1286
  14. Kim YG, Sun BJ, Park GM, Han S, Kim DH, Song JM, Kang DH, Song JK. Aortopathy and bicuspid aortic valve: haemodynamic burden is main contributor to aortic dilatation. Heart 2012;98:1822-7. https://doi.org/10.1136/heartjnl-2012-302828
  15. Hahn RT, Roman MJ, Mogtader AH, Devereux RB. Association of aortic dilation with regurgitant, stenotic and functionally normal bicuspid aortic valves. J Am Coll Cardiol 1992;19:283-8. https://doi.org/10.1016/0735-1097(92)90479-7
  16. Keane MG, Wiegers SE, Plappert T, Pochettino A, Bavaria JE, Sutton MG. Bicuspid aortic valves are associated with aortic dilatation out of proportion to coexistent valvular lesions. Circulation 2000;102(19 Suppl 3):III35-9. https://doi.org/10.1161/01.CIR.102.1.35
  17. Beroukhim RS, Kruzick TL, Taylor AL, Gao D, Yetman AT. Progression of aortic dilation in children with a functionally normal bicuspid aortic valve. Am J Cardiol 2006;98:828-30. https://doi.org/10.1016/j.amjcard.2006.04.022
  18. Della Corte A, Bancone C, Quarto C, Dialetto G, Covino FE, Scardone M, Caianiello G, Cotrufo M. Predictors of ascending aortic dilatation with bicuspid aortic valve: a wide spectrum of disease expression. Eur J Cardiothorac Surg 2007;31:397-404; discussion 404-5. https://doi.org/10.1016/j.ejcts.2006.12.006
  19. Yasuda H, Nakatani S, Stugaard M, Tsujita-Kuroda Y, Bando K, Kobayashi J, Yamagishi M, Kitakaze M, Kitamura S, Miyatake K. Failure to prevent progressive dilation of ascending aorta by aortic valve replacement in patients with bicuspid aortic valve: comparison with tricuspid aortic valve. Circulation 2003;108 Suppl 1:II291-4.
  20. Huntington K, Hunter AG, Chan KL. A prospective study to assess the frequency of familial clustering of congenital bicuspid aortic valve. J Am Coll Cardiol 1997;30:1809-12. https://doi.org/10.1016/S0735-1097(97)00372-0
  21. Cripe L, Andelfinger G, Martin LJ, Shooner K, Benson DW. Bicuspid aortic valve is heritable. J Am Coll Cardiol 2004;44:138-43. https://doi.org/10.1016/j.jacc.2004.03.050
  22. Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Grossfeld PD, Srivastava D. Mutations in NOTCH1 cause aortic valve disease. Nature 2005;437:270-4. https://doi.org/10.1038/nature03940
  23. Mohamed SA, Aherrahrou Z, Liptau H, Erasmi AW, Hagemann C, Wrobel S, Borzym K, Schunkert H, Sievers HH, Erdmann J. Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve. Biochem Biophys Res Commun 2006;345:1460-5. https://doi.org/10.1016/j.bbrc.2006.05.046
  24. Forte A, Della Corte A, Grossi M, Bancone C, Provenzano R, Finicelli M, De Feo M, De Santo LS, Nappi G, Cotrufo M, Galderisi U, Cipollaro M. Early cell changes and TGF${\beta}$ pathway alterations in the aortopathy associated with bicuspid aortic valve stenosis. Clin Sci (Lond) 2013;124:97-108. https://doi.org/10.1042/CS20120324
  25. Charitos EI, Stierle U, Petersen M, Mohamed SA, Hanke T, Schmidtke C, Klotz S, Sievers HH. The fate of the bicuspid valve aortopathy after aortic valve replacement. Eur J Cardiothorac Surg 2014;45:e128-35. https://doi.org/10.1093/ejcts/ezt666
  26. Kari FA, Fazel SS, Mitchell RS, Fischbein MP, Miller DC. Bicuspid aortic valve configuration and aortopathy pattern might represent different pathophysiologic substrates. J Thorac Cardiovasc Surg 2012;144:516-7. https://doi.org/10.1016/j.jtcvs.2012.05.035
  27. Della Corte A, Bancone C, Dialetto G, Covino FE, Manduca S, Montibello MV, De Feo M, Buonocore M, Nappi G. The ascending aorta with bicuspid aortic valve: a phenotypic classification with potential prognostic significance. Eur J Cardiothorac Surg 2014;46:240-7; discussion 247. https://doi.org/10.1093/ejcts/ezt621
  28. Hope MD, Hope TA, Meadows AK, Ordovas KG, Urbania TH, Alley MT, Higgins CB. Bicuspid aortic valve: four-dimensional MR evaluation of ascending aortic systolic flow patterns. Radiology 2010;255:53-61. https://doi.org/10.1148/radiol.09091437
  29. Mahadevia R, Barker AJ, Schnell S, Entezari P, Kansal P, Fedak PW, Malaisrie SC, McCarthy P, Collins J, Carr J, Markl M. Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy. Circulation 2014;129:673-82. https://doi.org/10.1161/CIRCULATIONAHA.113.003026
  30. Michelena HI, Desjardins VA, Avierinos JF, Russo A, Nkomo VT, Sundt TM, Pellikka PA, Tajik AJ, Enriquez-Sarano M. Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the community. Circulation 2008;117:2776-84. https://doi.org/10.1161/CIRCULATIONAHA.107.740878
  31. Tzemos N, Therrien J, Yip J, Thanassoulis G, Tremblay S, Jamorski MT, Webb GD, Siu SC. Outcomes in adults with bicuspid aortic valves. JAMA 2008;300:1317-25. https://doi.org/10.1001/jama.300.11.1317
  32. Hardikar AA, Marwick TH. Surgical thresholds for bicuspid aortic valve associated aortopathy. JACC Cardiovasc Imaging 2013;6:1311-20. https://doi.org/10.1016/j.jcmg.2013.10.005
  33. Kallenbach K, Sundt TM, Marwick TH. Aortic surgery for ascending aortic aneurysms under 5.0 cm in diameter in the presence of bicuspid aortic valve. JACC Cardiovasc Imaging 2013;6:1321-6. https://doi.org/10.1016/j.jcmg.2013.08.009
  34. Verma S, Yanagawa B, Kalra S, Ruel M, Peterson MD, Yamashita MH, Fagan A, Currie ME, White CW, Wai Sang SL, Rosu C, Singh S, Mewhort H, Gupta N, Fedak PW. Knowledge, attitudes, and practice patterns in surgical management of bicuspid aortopathy: a survey of 100 cardiac surgeons. J Thorac Cardiovasc Surg 2013;146:1033-40.e4. https://doi.org/10.1016/j.jtcvs.2013.06.037
  35. Barker AJ, Robinson JD, Markl M. Bicuspid aortic valve phenotype and aortopathy: nomenclature and role of aortic hemodynamics. JACC Cardiovasc Imaging 2013;6:921.
  36. Della Corte A. Phenotypic heterogeneity of bicuspid aortopathy: a potential key to decode the prognosis? Heart 2014;100:96-7. https://doi.org/10.1136/heartjnl-2013-305004

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  3. Bicuspid aortic valve outcomes vol.27, pp.3, 2015, https://doi.org/10.1017/s1047951116002560
  4. Evolution of Precision Medicine and Surgical Strategies for Bicuspid Aortic Valve-Associated Aortopathy vol.8, pp.None, 2015, https://doi.org/10.3389/fphys.2017.00475
  5. Misclassification of bicuspid aortic valves is common and varies by imaging modality and patient characteristics vol.36, pp.4, 2019, https://doi.org/10.1111/echo.14295
  6. Risk Factors Associated with Ascending Aortic Aneurysms and Aortic Elasticity Parameters in Children with a Bicuspid Aortic Valve vol.40, pp.5, 2015, https://doi.org/10.1007/s00246-019-02102-6