Korean Journal of Radiology

  • 제16권4호
  • /
  • Pages.791-797
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  • 2015
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  • 1229-6929(pISSN)
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  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지
DOI QR코드

DOI QR Code

Permeability Parameters Measured with Dynamic Contrast-Enhanced MRI: Correlation with the Extravasation of Evans Blue in a Rat Model of Transient Cerebral Ischemia

  • Choi, Hyun Seok (Department of Radiology, College of Medicine, The Catholic University of Korea) ;
  • Ahn, Sung Soo (Department of Radiology, College of Medicine, Yonsei University) ;
  • Shin, Na-Young (Department of Radiology, College of Medicine, Yonsei University) ;
  • Kim, Jinna (Department of Radiology, College of Medicine, Yonsei University) ;
  • Kim, Jae Hyung (Department of Radiology, College of Medicine, Seoul National University) ;
  • Lee, Jong Eun (Department of Anatomy, College of Medicine, Yonsei University) ;
  • Lee, Hye Yeon (Department of Anatomy, College of Medicine, Yonsei University) ;
  • Heo, Ji Hoe (Department of Neurology, College of Medicine, Yonsei University) ;
  • Lee, Seung-Koo (Department of Radiology, College of Medicine, Yonsei University)
  • 투고 : 2014.10.14
  • 심사 : 2015.03.16
  • 발행 : 2015.08.01
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia. Materials and Methods: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil. DCE-MRI was performed 12 hours, 18 hours, and 36 hours after reperfusion. Permeability parameters ($K^{trans}$, $v_e$, and $v_p$) from DCE-MRI were calculated. Evans blue was injected after DCE-MRI and extravasation of Evans blue was correlated as a reference with the integrity of the blood-brain barrier. Correlation analysis was performed between permeability parameters and the extravasation of Evans blue. Results: All permeability parameters ($K^{trans}$, $v_e$, and $v_p$) showed a linear correlation with extravasation of Evans blue. Among them, $K^{trans}$ showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001). Conclusion: Permeability parameters obtained by DCE-MRI at 3-T are well-correlated with Evans blue extravasation, and $K^{trans}$ shows the strongest correlation among the tested parameters.

키워드

과제정보

연구 과제번호 : 연세의과학사업단

참고문헌

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