Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Collateral Ventilation Quantification Using Xenon-Enhanced Dynamic Dual-Energy CT: Differences between Canine and Swine Models of Bronchial Occlusion

  • Park, Eun-Ah (Department of Radiology, Seoul National University College of Medicine and Institute of Radiation Medicine, Seoul National University Medical Research Center) ;
  • Goo, Jin Mo (Department of Radiology, Seoul National University College of Medicine and Institute of Radiation Medicine, Seoul National University Medical Research Center) ;
  • Park, Sang Joon (Department of Radiology, Seoul National University College of Medicine and Institute of Radiation Medicine, Seoul National University Medical Research Center) ;
  • Lee, Chang Hyun (Department of Radiology, Seoul National University College of Medicine and Institute of Radiation Medicine, Seoul National University Medical Research Center) ;
  • Park, Chang Min (Department of Radiology, Seoul National University College of Medicine and Institute of Radiation Medicine, Seoul National University Medical Research Center)
  • Received : 2014.07.29
  • Accepted : 2015.02.17
  • Published : 2015.06.01
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Abstract

Objective: The aim of this study was to evaluate whether the difference in the degree of collateral ventilation between canine and swine models of bronchial obstruction could be detected by using xenon-enhanced dynamic dual-energy CT. Materials and Methods: Eight mongrel dogs and six pigs underwent dynamic dual-energy scanning of 64-slice dual-source CT at 12-second interval for 2-minute wash-in period (60% xenon) and at 24-second interval for 3-minute wash-out period with segmental bronchus occluded. Ventilation parameters of magnitude (A value), maximal slope, velocity (K value), and time-to-peak (TTP) enhancement were calculated from dynamic xenon maps using exponential function of Kety model. Results: A larger difference in A value between parenchyma was observed in pigs than in dogs (absolute difference, $-33.0{\pm}5.0$ Hounsfield units [HU] vs. $-2.8{\pm}7.1$ HU, p = 0.001; normalized percentage difference, $-79.8{\pm}1.8%$ vs. $-5.4{\pm}16.4%$, p = 0.0007). Mean maximal slopes in both periods in the occluded parenchyma only decreased in pigs (all p < 0.05). K values of both periods were not different (p = 0.892) in dogs. However, a significant (p = 0.027) difference was found in pigs in the wash-in period. TTP was delayed in the occluded parenchyma in pigs (p = 0.013) but not in dogs (p = 0.892). Conclusion: Xenon-ventilation CT allows the quantification of collateral ventilation and detection of differences between canine and swine models of bronchial obstruction.

Keywords

References

  1. Tsai LW, Hoffman AM, Mazan MR, Ingenito EP. Bronchoscopic measurement of collateral ventilation in a sheep model of emphysema. Respiration 2007;74:565-571 https://doi.org/10.1159/000103514
  2. Cetti EJ, Moore AJ, Geddes DM. Collateral ventilation. Thorax 2006;61:371-373 https://doi.org/10.1136/thx.2006.060509
  3. Kohn HN. Zur Histologie der indurirenden fibrinosen Pneumonie. Munch Med Wochenschr 1893;40:42-45
  4. Van Allen CM, Lindskog GE, Richter HG. Gaseous Interchange Between Adjacent Lung Lobules. Yale J Biol Med 1930;2:297-300
  5. McLaughlin RF, Tyler WS, Canada RO. A study of the subgross pulmonary anatomy in various mammals. Am J Anat 1961;108:149-165 https://doi.org/10.1002/aja.1001080203
  6. Martin HB. Respiratory bronchioles as the pathway for collateral ventilation. J Appl Physiol 1966;21:1443-1447 https://doi.org/10.1152/jappl.1966.21.5.1443
  7. Hogg JC, Macklem PT, Thurlbeck WM. The resistance of collateral channels in excised human lungs. J Clin Invest 1969;48:421-431 https://doi.org/10.1172/JCI105999
  8. Macklem PT. Airway obstruction and collateral ventilation. Physiol Rev 1971;51:368-436 https://doi.org/10.1152/physrev.1971.51.2.368
  9. Taneja A. Bronchoscopic interventions in the management of chronic obstructive pulmonary disease. Curr Opin Pulm Med 2013;19:145-151 https://doi.org/10.1097/MCP.0b013e32835cfd59
  10. Sciurba FC, Ernst A, Herth FJ, Strange C, Criner GJ, Marquette CH, et al. A randomized study of endobronchial valves for advanced emphysema. N Engl J Med 2010;363:1233-1244 https://doi.org/10.1056/NEJMoa0900928
  11. Chae EJ, Seo JB, Goo HW, Kim N, Song KS, Lee SD, et al. Xenon ventilation CT with a dual-energy technique of dual-source CT: initial experience. Radiology 2008;248:615-624 https://doi.org/10.1148/radiol.2482071482
  12. Goo HW, Chae EJ, Seo JB, Hong SJ. Xenon ventilation CT using a dual-source dual-energy technique: dynamic ventilation abnormality in a child with bronchial atresia. Pediatr Radiol 2008;38:1113-1116 https://doi.org/10.1007/s00247-008-0914-x
  13. Chae EJ, Seo JB, Kim N, Song KS, Shin JH, Kim TH, et al. Collateral ventilation in a canine model with bronchial obstruction: assessment with xenon-enhanced dual-energy CT. Radiology 2010;255:790-798 https://doi.org/10.1148/radiol.10090947
  14. Park EA, Goo JM, Park SJ, Lee HJ, Lee CH, Park CM, et al. Chronic obstructive pulmonary disease: quantitative and visual ventilation pattern analysis at xenon ventilation CT performed by using a dual-energy technique. Radiology 2010;256:985-997 https://doi.org/10.1148/radiol.10091502
  15. Kim WW, Lee CH, Goo JM, Park SJ, Kim JH, Park EA, et al. Xenon-enhanced dual-energy CT of patients with asthma: dynamic ventilation changes after methacholine and salbutamol inhalation. AJR Am J Roentgenol 2012;199:975-981 https://doi.org/10.2214/AJR.11.7624
  16. Park SJ, Lee CH, Goo JM, Kim JH, Park EA, Jung JW, et al. Quantitative analysis of dynamic airway changes after methacholine and salbutamol inhalation on xenon-enhanced chest CT. Eur Radiol 2012;22:2441-2450 https://doi.org/10.1007/s00330-012-2516-0
  17. Robinson NE, Sorenson PR. Collateral flow resistance and time constants in dog and horse lungs. J Appl Physiol Respir Environ Exerc Physiol 1978;44:63-68
  18. Murphy DM, Nicewicz JT, Zabbatino SM, Moore RA. Local pulmonary ventilation using nonradioactive xenon-enhanced ultrafast computed tomography. Chest 1989;96:799-804 https://doi.org/10.1378/chest.96.4.799
  19. Lambert MW. Accessory bronchiolealveolar communications. J Pathol Bacteriol 1955;70:311-314 https://doi.org/10.1002/path.1700700206
  20. Terry PB, Traystman RJ, Newball HH, Batra G, Menkes HA. Collateral ventilation in man. N Engl J Med 1978;298:10-15 https://doi.org/10.1056/NEJM197801052980103
  21. Morrell NW, Wignall BK, Biggs T, Seed WA. Collateral ventilation and gas exchange in emphysema. Am J Respir Crit Care Med 1994;150:635-641 https://doi.org/10.1164/ajrccm.150.3.8087331
  22. Rosenberg DE, Lyons HA. Collateral ventilation in excised human lungs. Respiration 1979;37:125-134 https://doi.org/10.1159/000194018
  23. Herth FJ, Eberhardt R, Gompelmann D, Ficker JH, Wagner M, Ek L, et al. Radiological and clinical outcomes of using $Chartis^{TM}$ to plan endobronchial valve treatment. Eur Respir J 2013;41:302-308 https://doi.org/10.1183/09031936.00015312
  24. Effmann EL, Freedman GS, Lange RC. 133Xe studies of collateral ventilation and air trapping following endobronchial occlusion. Radiology 1972;105:85-91 https://doi.org/10.1148/105.1.85
  25. Salanitri J, Kalff V, Kelly M, Holsworth L, Williams T, Snell G. 133Xenon ventilation scintigraphy applied to bronchoscopic lung volume reduction techniques for emphysema: relevance of interlobar collaterals. Intern Med J 2005;35:97-103 https://doi.org/10.1111/j.1445-5994.2004.00746.x
  26. Nakano Y, Coxson HO, Bosan S, Rogers RM, Sciurba FC, Keenan RJ, et al. Core to rind distribution of severe emphysema predicts outcome of lung volume reduction surgery. Am J Respir Crit Care Med 2001;164:2195-2199 https://doi.org/10.1164/ajrccm.164.12.2012140
  27. Higuchi T, Reed A, Oto T, Holsworth L, Ellis S, Bailey MJ, et al. Relation of interlobar collaterals to radiological heterogeneity in severe emphysema. Thorax 2006;61:409-413 https://doi.org/10.1136/thx.2005.051219
  28. Washko GR, Martinez FJ, Hoffman EA, Loring SH, Estepar RS, Diaz AA, et al. Physiological and computed tomographic predictors of outcome from lung volume reduction surgery. Am J Respir Crit Care Med 2010;181:494-500 https://doi.org/10.1164/rccm.200906-0911OC
  29. Reymond E, Jankowski A, Pison C, Bosson JL, Prieur M, Aniwidyaningsih W, et al. Prediction of lobar collateral ventilation in 25 patients with severe emphysema by fissure analysis with CT. AJR Am J Roentgenol 2013;201:W571-W575 https://doi.org/10.2214/AJR.12.9843
  30. Gompelmann D, Eberhardt R, Slebos DJ, Brown MS, Abtin F, Kim HJ, et al. Diagnostic performance comparison of the Chartis System and high-resolution computerized tomography fissure analysis for planning endoscopic lung volume reduction. Respirology 2014;19:524-530 https://doi.org/10.1111/resp.12253
  31. Hoag JB, Fuld M, Brown RH, Simon BA. Recirculation of inhaled xenon does not alter lung CT density. Acad Radiol 2007;14:81-84 https://doi.org/10.1016/j.acra.2006.10.012

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