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Assessment of Bone Age in Prepubertal Healthy Korean Children: Comparison among the Korean Standard Bone Age Chart, Greulich-Pyle Method, and Tanner-Whitehouse Method

  • Kim, Jeong Rye (Department of Radiology, Dankook University Hospital) ;
  • Lee, Young Seok (Department of Radiology, Dankook University Hospital) ;
  • Yu, Jeesuk (Department of Pediatrics, Dankook University Hospital)
  • Received : 2014.07.17
  • Accepted : 2014.10.28
  • Published : 2015.02.01

Abstract

Objective: To compare the reliability of the Greulich-Pyle (GP) method, Tanner-Whitehouse 3 (TW3) method and Korean standard bone age chart (KS) in the evaluation of bone age of prepubertal healthy Korean children. Materials and Methods: Left hand-wrist radiographs of 212 prepubertal healthy Korean children aged 7 to 12 years, obtained for the evaluation of the traumatic injury in emergency department, were analyzed by two observers. Bone age was estimated using the GP method, TW3 method and KS, and was calculated in months. The correlation between bone age measured by each method and chronological age of each child was analyzed using Pearson correlation coefficient, scatterplot. The three methods were compared using one-way analysis of variance. Results: Significant correlations were found between chronological age and bone age estimated by all three methods in whole group and in each gender (R2 ranged from 0.87 to 0.9, p < 0.01). Although bone age estimated by KS was slightly closer to chronological age than those estimated by the GP and TW3 methods, the difference between three methods was not statistically significant (p > 0.01). Conclusion: The KS, GP, and TW3 methods show good reliability in the evaluation of bone age of prepubertal healthy Korean children without significant difference between them. Any are useful for evaluation of bone age in prepubertal healthy Korean children.

Keywords

References

  1. Zerin JM, Hernandez RJ. Approach to skeletal maturation. Hand Clin 1991;7:53-62
  2. Greulich WW, Pyle SI. Radiographic atlas of skeletal development of hand wrist. Stanford: Stanford University Press, 1971
  3. Tanner JM, Healy MJ, Goldstein H, Cameron N. Assessment of skeletal maturity and prediction of adult height (TW3 method). London: W.B Saunders Company, 2001
  4. Ontell FK, Ivanovic M, Ablin DS, Barlow TW. Bone age in children of diverse ethnicity. AJR Am J Roentgenol 1996;167:1395-1398 https://doi.org/10.2214/ajr.167.6.8956565
  5. Zhang A, Sayre JW, Vachon L, Liu BJ, Huang HK. Racial differences in growth patterns of children assessed on the basis of bone age. Radiology 2009;250:228-235 https://doi.org/10.1148/radiol.2493080468
  6. Yeon KM, Kim IO. Standard atlas of bone-age in Korean children. Seoul: Sungmoonbook, 1999
  7. Yeon KM. Standard bone-age of infants and children in Korea. J Korean Med Sci 1997;12:9-16 https://doi.org/10.3346/jkms.1997.12.1.9
  8. Kim SY, Oh YJ, Shin JY, Rhie YJ, Lee KH. Comparison of the Greulich-Pyle and Tanner Whitehouse (TW3) methods in bone age assessment. J Korean Soc Pediatr Endocrinol 2008;13:50-55
  9. Vignolo M, Milani S, DiBattista E, Naselli A, Mostert M, Aicardi G. Modified Greulich-Pyle, Tanner-Whitehouse, and Roche-Wainer-Thissen (knee) methods for skeletal age assessment in a group of Italian children and adolescents. Eur J Pediatr 1990;149:314-317 https://doi.org/10.1007/BF02171555
  10. Cole AJ, Webb L, Cole TJ. Bone age estimation: a comparison of methods. Br J Radiol 1988;61:683-686 https://doi.org/10.1259/0007-1285-61-728-683
  11. Milner GR, Levick RK, Kay R. Assessment of bone age: a comparison of the Greulich and Pyle, and the Tanner and Whitehouse methods. Clin Radiol 1986;37:119-121 https://doi.org/10.1016/S0009-9260(86)80376-2
  12. Bull RK, Edwards PD, Kemp PM, Fry S, Hughes IA. Bone age assessment: a large scale comparison of the Greulich and Pyle, and Tanner and Whitehouse (TW2) methods. Arch Dis Child 1999;81:172-173 https://doi.org/10.1136/adc.81.2.172
  13. Ashizawa K, Asami T, Anzo M, Matsuo N, Matsuoka H, Murata M, et al. Standard RUS skeletal maturation of Tokyo children. Ann Hum Biol 1996;23:457-469 https://doi.org/10.1080/03014469600004682
  14. Zhen OY, Baolin L. Skeletal maturity of the hand and wrist in Chinese school children in Harbin assessed by the TW2 method. Ann Hum Biol 1986;13:183-187 https://doi.org/10.1080/03014468600008331

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