Korean Journal of Radiology

  • 제16권1호
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  • Pages.139-145
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  • 2015
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  • 1229-6929(pISSN)
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  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지
DOI QR코드

DOI QR Code

Segmental Quantitative MR Imaging Analysis of Diurnal Variation of Water Content in the Lumbar Intervertebral Discs

  • Zhu, Tingting (Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Ai, Tao (Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Zhang, Wei (Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Li, Tao (Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) ;
  • Li, Xiaoming (Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology)
  • 투고 : 2013.11.17
  • 심사 : 2014.10.24
  • 발행 : 2015.02.01
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: To investigate the changes in water content in the lumbar intervertebral discs by quantitative T2 MR imaging in the morning after bed rest and evening after a diurnal load. Materials and Methods: Twenty healthy volunteers were separately examined in the morning after bed rest and in the evening after finishing daily work. T2-mapping images were obtained and analyzed. An equally-sized rectangular region of interest (ROI) was manually placed in both, the anterior and the posterior annulus fibrosus (AF), in the outermost 20% of the disc. Three ROIs were placed in the space defined as the nucleus pulposus (NP). Repeated-measures analysis of variance and paired 2-tailed t tests were used for statistical analysis, with p < 0.05 as significantly different. Results: T2 values significantly decreased from morning to evening, in the NP (anterior NP = -13.9 ms; central NP = -17.0 ms; posterior NP = -13.3 ms; all p < 0.001). Meanwhile T2 values significantly increased in the anterior AF (+2.9 ms; p = 0.025) and the posterior AF (+5.9 ms; p < 0.001). T2 values in the posterior AF showed the largest degree of variation among the 5 ROIs, but there was no statistical significance (p = 0.414). Discs with initially low T2 values in the center NP showed a smaller degree of variation in the anterior NP and in the central NP, than in discs with initially high T2 values in the center NP (10.0% vs. 16.1%, p = 0.037; 6.4% vs. 16.1%, p = 0.006, respectively). Conclusion: Segmental quantitative T2 MRI provides valuable insights into physiological aspects of normal discs.

키워드

참고문헌

  1. Adams MA, Dolan P, Hutton WC, Porter RW. Diurnal changes in spinal mechanics and their clinical significance. J Bone Joint Surg Br 1990;72:266-270
  2. Malko JA, Hutton WC, Fajman WA. An in vivo MRI study of the changes in volume (and fluid content) of the lumbar intervertebral disc after overnight bed rest and during an 8-hour walking protocol. J Spinal Disord Tech 2002;15:157-163 https://doi.org/10.1097/00024720-200204000-00012
  3. Watanabe A, Benneker LM, Boesch C, Watanabe T, Obata T, Anderson SE. Classification of intervertebral disk degeneration with axial T2 mapping. AJR Am J Roentgenol 2007;189:936-942 https://doi.org/10.2214/AJR.07.2142
  4. Stelzeneder D, Welsch GH, Kovacs BK, Goed S, Paternostro-Sluga T, Vlychou M, et al. Quantitative T2 evaluation at 3.0T compared to morphological grading of the lumbar intervertebral disc: a standardized evaluation approach in patients with low back pain. Eur J Radiol 2012;81:324-330 https://doi.org/10.1016/j.ejrad.2010.12.093
  5. Marinelli NL, Haughton VM, Munoz A, Anderson PA. T2 relaxation times of intervertebral disc tissue correlated with water content and proteoglycan content. Spine (Phila Pa 1976) 2009;34:520-524 https://doi.org/10.1097/BRS.0b013e318195dd44
  6. Marinelli NL, Haughton VM, Anderson PA. T2 relaxation times correlated with stage of lumbar intervertebral disk degeneration and patient age. AJNR Am J Neuroradiol 2010;31:1278-1282 https://doi.org/10.3174/ajnr.A2080
  7. Karakida O, Ueda H, Ueda M, Miyasaka T. Diurnal T2 value changes in the lumbar intervertebral discs. Clin Radiol 2003;58:389-392 https://doi.org/10.1016/S0009-9260(02)00583-4
  8. Malko JA, Hutton WC, Fajman WA. An in vivo magnetic resonance imaging study of changes in the volume (and fluid content) of the lumbar intervertebral discs during a simulated diurnal load cycle. Spine (Phila Pa 1976) 1999;24:1015-1022 https://doi.org/10.1097/00007632-199905150-00016
  9. Roberts N, Hogg D, Whitehouse GH, Dangerfield P. Quantitative analysis of diurnal variation in volume and water content of lumbar intervertebral discs. Clin Anat 1998;11:1-8 https://doi.org/10.1002/(SICI)1098-2353(1998)11:1<1::AID-CA1>3.0.CO;2-Z
  10. Weishaupt D, Zanetti M, Hodler J, Boos N. MR imaging of the lumbar spine: prevalence of intervertebral disk extrusion and sequestration, nerve root compression, end plate abnormalities, and osteoarthritis of the facet joints in asymptomatic volunteers. Radiology 1998;209:661-666 https://doi.org/10.1148/radiology.209.3.9844656
  11. Welsch GH, Trattnig S, Paternostro-Sluga T, Bohndorf K, Goed S, Stelzeneder D, et al. Parametric T2 and T2* mapping techniques to visualize intervertebral disc degeneration in patients with low back pain: initial results on the clinical use of 3.0 Tesla MRI. Skeletal Radiol 2011;40:543-551 https://doi.org/10.1007/s00256-010-1036-8
  12. Ludescher B, Effelsberg J, Martirosian P, Steidle G, Markert B, Claussen C, et al. T2-and diffusion-maps reveal diurnal changes of intervertebral disc composition: an in vivo MRI study at 1.5 Tesla. J Magn Reson Imaging 2008;28:252-257 https://doi.org/10.1002/jmri.21390
  13. Boos N, Wallin A, Aebi M, Boesch C. A new magnetic resonance imaging analysis method for the measurement of disc height variations. Spine (Phila Pa 1976) 1996;21:563-570 https://doi.org/10.1097/00007632-199603010-00006
  14. Stelzeneder D, Kovacs BK, Goed S, Welsch GH, Hirschfeld C, Paternostro-Sluga T, et al. Effect of short-term unloading on T2 relaxation time in the lumbar intervertebral disc--in vivo magnetic resonance imaging study at 3.0 tesla. Spine J 2012;12:257-264 https://doi.org/10.1016/j.spinee.2012.02.001
  15. Jazini E, Sharan AD, Morse LJ, Dyke JP, Aronowitz EB, Chen LK, et al. Alterations in T2 relaxation magnetic resonance imaging of the ovine intervertebral disc due to nonenzymatic glycation. Spine (Phila Pa 1976) 2012;37:E209-E215 https://doi.org/10.1097/BRS.0b013e31822ce81f
  16. Burstein D, Gray ML. Is MRI fulfilling its promise for molecular imaging of cartilage in arthritis? Osteoarthritis Cartilage 2006;14:1087-1090 https://doi.org/10.1016/j.joca.2006.07.001
  17. Welsch GH, Trattnig S, Domayer S, Marlovits S, White LM, Mamisch TC. Multimodal approach in the use of clinical scoring, morphological MRI and biochemical T2-mapping and diffusion-weighted imaging in their ability to assess differences between cartilage repair tissue after microfracture therapy and matrix-associated autologous chondrocyte transplantation: a pilot study. Osteoarthritis Cartilage 2009;17:1219-1227 https://doi.org/10.1016/j.joca.2009.03.018
  18. Drew SC, Silva P, Crozier S, Pearcy MJ. A diffusion and T2 relaxation MRI study of the ovine lumbar intervertebral disc under compression in vitro. Phys Med Biol 2004;49:3585-3592 https://doi.org/10.1088/0031-9155/49/16/006
  19. Chiu EJ, Newitt DC, Segal MR, Hu SS, Lotz JC, Majumdar S. Magnetic resonance imaging measurement of relaxation and water diffusion in the human lumbar intervertebral disc under compression in vitro. Spine (Phila Pa 1976) 2001;26:E437-E444 https://doi.org/10.1097/00007632-200110010-00017
  20. Trattnig S, Stelzeneder D, Goed S, Reissegger M, Mamisch TC, Paternostro-Sluga T, et al. Lumbar intervertebral disc abnormalities: comparison of quantitative T2 mapping with conventional MR at 3.0 T. Eur Radiol 2010;20:2715-2722 https://doi.org/10.1007/s00330-010-1843-2
  21. Perry J, Haughton V, Anderson PA, Wu Y, Fine J, Mistretta C. The value of T2 relaxation times to characterize lumbar intervertebral disks: preliminary results. AJNR Am J Neuroradiol 2006;27:337-342
  22. Zou J, Yang H, Miyazaki M, Morishita Y, Wei F, McGovern S, et al. Dynamic bulging of intervertebral discs in the degenerative lumbar spine. Spine (Phila Pa 1976) 2009;34:2545-2550 https://doi.org/10.1097/BRS.0b013e3181b32998

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