Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)
- Volume 1 Issue 2
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- Pages.137-144
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- 2015
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- 2384-1583(pISSN)
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- 2508-3848(eISSN)
DOI QR Code
Biodistribution and PET imaging of [18F]FMISO in mousecolon cancer xenografted mice
- Seelam, Sudhakara Reddy (Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine) ;
- Lee, Ji Youn (Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine) ;
- Kim, Young Joo (Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine) ;
- Lee, Yun-Sang (Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine) ;
- Jeong, Jae Min (Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine)
- Received : 2015.10.23
- Accepted : 2015.12.24
- Published : 2015.12.30
Abstract
Hypoxia is an important adverse prognostic factor for tumor progression and is a major cause of failure of radiation therapy. In case of short-term hypoxia, the metabolism can recover to normal, but if hypoxia persists, it causes irreversible cell damage and finally leads to death. So a hypoxia marker would be very useful in oncology. In particular, 2-nitroimidazole can be reduced to form a reactive chemical species, which can bind irreversibly to cell components in the absence of sufficient oxygen, thus, the development of radiolabeled nitroimidazole derivatives for the imaging of hypoxia remains an active field of research to improve cancer therapy result. 2-nitroimidazole based hypoxia marker, [