Asian Pacific Journal of Cancer Prevention

  • 제16권11호
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  • Pages.4503-4508
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  • 2015
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Relations of Serum Visfatin and Resistin Levels with Endometrial Cancer and Factors Associated with its Prognosis

  • 발행 : 2015.06.26
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Background: The aims of this study were compare the serum visfatin and resistin levels between endometrial cancer (EC) patients and controls and evaluate their power to predict prognosis. Materials and Methods: This prospective study was conducted between March 2013 to June 2014 on the Gynecologic Oncology Department of the University of Selcuk, Konya, Turkey. A total of 42 EC patients and 42 controls were included and assessed for differences in serum visfatin and resistin levels, along with prognostic factors. Results: Endometrial cancer patients had significantly higher visfatin levels than control s (p: 0.011), associated with deep myometrial invasion (p: 0.019). In contrast the serum level of resistin did not significantly differ between EC patients and controls (p: 0.362). However, high resistin level in EC patients was associated with increase lymph node metastasis (p: 0.009). On logistic regression analysis, we found that serum visfatin elevation was associated with risk of myometrial invasion (OR: 1,091; 95%CI: 1.021-1.166; p: 0.010) and serum resistin with risk of lymph node metastasis (OR: 1.018; 95%CI: 1.000-1.035; p: 0.046). For myometrial invasion prediction, a serum visfatin level greater than 26.8 ng/mL demonstrated a sensitivity and specificity of 66.6 % and 96.4%, respectively. For lymph node metastasis prediction, the best cut-off for serum resistin level was 599ng/mL. A serum resistin level greater than this demonstrated a sensitivity and specificity of 87.5% and 77.1%, respectively. Conclusions: Our data suggest that serum visfatin is elevated in patients with EC and serum visfatin and resistin levels could be used to predict the risk of advance stage lesions.

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참고문헌

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피인용 문헌

  1. Discovery of biomarkers for endometrial cancer: current status and prospects vol.16, pp.12, 2016, https://doi.org/10.1080/14737159.2016.1258302
  2. Circulating Serum Level of Visfatin in Patients with Endometrial Cancer vol.2018, pp.2314-6141, 2018, https://doi.org/10.1155/2018/8576179
  3. Circulating visfatin levels and cancers risk: A systematic review and meta-analysis pp.00219541, 2018, https://doi.org/10.1002/jcp.27302
  4. The Correlation of Visfatin and Its Gene Polymorphism with Non-Small Cell Lung Cancer pp.1557-8852, 2018, https://doi.org/10.1089/cbr.2018.2526
  5. Novel oncogenic and chemoresistance-inducing functions of resistin in ovarian cancer cells require miRNAs-mediated induction of epithelial-to-mesenchymal transition vol.8, pp.1, 2018, https://doi.org/10.1038/s41598-018-30978-6