The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Clinical outcomes of extracorporeal membrane oxygenation support in patients with hematologic malignancies

  • Kang, Hye Seon (Divisions of Pulmonary, Allergy and Critical Care Medicine, College of Medicine, The Catholic University of Korea) ;
  • Rhee, Chin Kook (Divisions of Pulmonary, Allergy and Critical Care Medicine, College of Medicine, The Catholic University of Korea) ;
  • Lee, Hea Yon (Divisions of Pulmonary, Allergy and Critical Care Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kim, Young Kyoon (Divisions of Pulmonary, Allergy and Critical Care Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kwon, Soon Seog (Divisions of Pulmonary, Allergy and Critical Care Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kim, Seok Chan (Divisions of Pulmonary, Allergy and Critical Care Medicine, College of Medicine, The Catholic University of Korea) ;
  • Lee, Jong Wook (Divisions of Hematology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea)
  • Received : 2014.04.15
  • Accepted : 2014.09.01
  • Published : 2015.07.01
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Abstract

Background/Aims: The clinical outcomes of patients with hematologic malignancies who were treated with extracorporeal membrane oxygenation (ECMO) after the failu re of optimal conventional therapy were determined. Methods: The medical records of all patients administered ECMO during their stay in a medical intensive care unit of Seoul St. Mary's Hospital between February 2010 and July 2013 were reviewed retrospectively. Results: In total, 15 patients with hematologic malignancies were compared to 33 immunocompetent patients with documented cardiorespiratory failure. Underlying hematologic malignancies were significantly associated with lower overall survival (0.0% vs. 24.2%, p = 0.044). Mortality was significantly associated with a higher 24 hours ECMO inspired fraction of oxygen ($0.71{\pm}0.24$ vs. $0.47{\pm}0.13$, p = 0.015), the development of infection after ECMO (87.5% vs. 25.0%, p = 0.001), and the presence of hyperbilirubinemia (70.0% vs. 0.0%, p < 0.001). Matching of the patients based on their Acute Physiology and Chronic Health Evaluation II scores confirmed the greater risk of mortality in patients with hematologic malignancies (survival: 0.0% vs. 40.0%, p = 0.017). The mean difference in inotropic-equivalent scores after ECMO was significantly lower in the immunocompetent patients than in those with hematologic malignancies ($-59.22{\pm}97.83$ vs. $53.87{\pm}164.46$, p = 0.026). Conclusions: Patients with hematologic malignancies who require ECMO for respiratory support have poor outcomes. The incidence of complications in these patients did not significantly differ from that in immunocompetent patients.

Keywords

References

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