The Korean journal of internal medicine

  • 제30권3호
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  • Pages.316-324
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  • 2015
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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DOI QR Code

The relationship between serum asymmetric dimethylarginine levels and subjective sleep quality in normotensive patients with type 2 diabetes mellitus

  • Aribas, Alpay (Department of Cardiology, Meram School of Medicine Hospital, Necmettin Erbakan University) ;
  • Kayrak, Mehmet (Department of Cardiology, Meram School of Medicine Hospital, Necmettin Erbakan University) ;
  • Tekinalp, Mehmet (Cardiology Clinic, Kahramanmaras Necip Fazil City Hospital) ;
  • Akilli, Hakan (Department of Cardiology, Meram School of Medicine Hospital, Necmettin Erbakan University) ;
  • Alibasic, Hayrudin (Cardiology Clinic, Lokman Hekim Van Hospital) ;
  • Yildirim, Serkan (Department of Cardiology, Meram School of Medicine Hospital, Necmettin Erbakan University) ;
  • Gunduz, Mehmet (Department of Cardiology, Ercis Government Hospital) ;
  • Taner, Alpaslan (Department of Biochemistry, Dr Faruk Sukan Maternity and Children's Hospital) ;
  • Unlu, Ali (Department of Biochemistry, Selcuk University School of Medicine)
  • 투고 : 2014.05.28
  • 심사 : 2014.11.14
  • 발행 : 2015.05.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Poor sleep quality (SQ) is associated with increased cardiovascular mortality and morbidity. Additionally, asymmetric dimethylarginine (ADMA) is an independent predictor of cardiovascular mortality and morbidity. However, no sufficient data regarding the relationship between ADMA levels and SQ have been reported. The goal of the current study was to evaluate the association between SQ and ADMA levels in normotensive patients with type 2 diabetes mellitus. Methods: The study participants consisted of 78 normotensive type 2 diabetics. The SQ of all participants was assessed using the Pittsburgh Sleep Quality Index (PSQI). Patients with a global PSQI score > 5 were defined as "poor sleepers." Factors associated with poor SQ were analyzed using a multiple regression model. Serum ADMA levels were measured using high performance liquid chromatography. Results: The median ADMA levels of the poor sleepers were increased compared with patients defined as good sleepers (5.5 [4.2 to 6.6] vs. 4.4 [2.9 to 5.4], p < 0.01, respectively). However, the L-arginine/ADMA ratio was decreased in poor sleepers (p < 0.01). Global PSQI scores were positively correlated with ADMA levels (p < 0.01) and negatively correlated with the L-arginine/ADMA ratio (p = 0.02). ADMA levels were correlated with sleep latency (p < 0.01) and sleep efficiency (p = 0.01). Logistic regression analysis showed that ADMA levels (odds ratio [OR], 1.68; 95% confidence interval [CI], 1.16 to 2.44; p = 0.01) and body mass index (OR, 1.15; 95% CI, 1.01 to 1.31; p = 0.04) were associated with poor SQ independently of glomerular filtration rate, sex, age, duration of diabetes, hemoglobin $A_{1c}$, total cholesterol, and systolic blood pressure. Conclusions: Self-reported SQ was independently associated with ADMA levels in normotensive patients with diabetes mellitus.

키워드

과제정보

연구 과제 주관 기관 : Selcuk University

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