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A 45-Year-Old Man With Recurrent Dyspnea and Hemoptysis during Exercise: Exercise-Induced Pulmonary Hemorrhage/Edema

  • Kim, Dae Sung (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Konyang University Hospital) ;
  • Lee, Minhyeok (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Konyang University Hospital) ;
  • Kwon, Oh Jung (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Konyang University Hospital) ;
  • Jeong, Inbeom (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Konyang University Hospital) ;
  • Son, Ji Woong (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Konyang University Hospital) ;
  • Na, Moon Jun (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Konyang University Hospital) ;
  • Kwon, Sun Jung (Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Konyang University Hospital)
  • Received : 2015.04.22
  • Accepted : 2015.06.23
  • Published : 2015.10.30

Abstract

A 45-year-old man presented with dyspnea and hemoptysis during exercise. A chest computed tomography (CT) revealed multifocal diffuse patchy ground glass opacity and interlobular septal thickening in both the lungs. Permeability pulmonary edema or pulmonary hemorrhage was suspected. Serologic studies for autoimmune disorders and vasculitis were negative. There was no laboratory evidence of coagulopathy, other hematopoietic disease or infectious disease. Considering correlation with exercise, we diagnosed exercise-induced pulmonary hemorrhage (EIPH) or exercise-induced pulmonary edema (EIPE). The patient was managed with antifibrinolytics, antibiotics, and antitussive agent. After a week, follow-up chest CT revealed completely resolved pulmonary hemorrhage. About 2 months after the first event, he visited again with dyspnea and hemoptysis during running. In the present study, we report a case of recurrent pulmonary hemorrhage after exercise.

Keywords

References

  1. Ghio AJ, Ghio C, Bassett M. Exercise-induced pulmonary hemorrhage after running a marathon. Lung 2006;184:331-3. https://doi.org/10.1007/s00408-006-0023-2
  2. McKechnie JK, Leary WP, Noakes TD, Kallmeyer JC, MacSearraigh ET, Olivier LR. Acute pulmonary oedema in two athletes during a 90-km running race. S Afr Med J 1979;56:261-5.
  3. Luks AM, Robertson HT, Swenson ER. An ultracyclist with pulmonary edema during the Bicycle Race Across America. Med Sci Sports Exerc 2007;39:8-12. https://doi.org/10.1249/01.mss.0000235885.79110.79
  4. Lund KL, Mahon RT, Tanen DA, Bakhda S. Swimminginduced pulmonary edema. Ann Emerg Med 2003;41:251-6. https://doi.org/10.1067/mem.2003.69
  5. West JB, Mathieu-Costello O, Jones JH, Birks EK, Logemann RB, Pascoe JR, et al. Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary hemorrhage. J Appl Physiol (1985) 1993;75:1097-109. https://doi.org/10.1152/jappl.1993.75.3.1097
  6. Kindig CA, McDonough P, Fenton G, Poole DC, Erickson HH. Efficacy of nasal strip and furosemide in mitigating EIPH in Thoroughbred horses. J Appl Physiol (1985) 2001;91:1396-400. https://doi.org/10.1152/jappl.2001.91.3.1396
  7. Williams KJ, Robinson NE, Defeijter-Rupp H, Millerick-May M, Stack A, Hauptman J, et al. Distribution of venous remodeling in exercise-induced pulmonary hemorrhage of horses follows reported blood flow distribution in the equine lung. J Appl Physiol (1985) 2013;114:869-78. https://doi.org/10.1152/japplphysiol.01170.2012
  8. Sinha AK, Gleed RD, Hakim TS, Dobson A, Shannon KJ. Pulmonary capillary pressure during exercise in horses. J Appl Physiol (1985) 1996;80:1792-8. https://doi.org/10.1152/jappl.1996.80.5.1792
  9. Williams KJ, Derksen FJ, de Feijter-Rupp H, Pannirselvam RR, Steel CM, Robinson NE. Regional pulmonary veno-occlusion: a newly identified lesion of equine exercise-induced pulmonary hemorrhage. Vet Pathol 2008;45:316-26. https://doi.org/10.1354/vp.45-3-316
  10. Derksen F, Williams K, Stack A. Exercise-induced pulmonary hemorrhage in horses: the role of pulmonary veins. Compend Contin Educ Vet 2011;33:E6.
  11. Hull JH, Menzies-Gow A, Nicholson AG, Mohiaddin RH, Maher TM. Exercise-induced haemoptysis: a thoroughbred cause? Thorax 2013;68:599-600. https://doi.org/10.1136/thoraxjnl-2012-202209
  12. West JB. Invited review: pulmonary capillary stress failure. J Appl Physiol (1985) 2000;89:2483-9. https://doi.org/10.1152/jappl.2000.89.6.2483
  13. Hinchcliff KW. Exercise-induced pulmonary hemorrhage. In: Pagan JD, editor. Advanced in equine nutrition. Vol. IV. Nottingham: Nottingham University Press; 2009. p. 367-77.
  14. Manohar M, Hutchens E, Coney E. Frusemide attenuates the exercise-induced rise in pulmonary capillary blood pressure in horses. Equine Vet J 1994;26:51-4. https://doi.org/10.1111/j.2042-3306.1994.tb04331.x
  15. Epp TS, McDonough P, Padilla DJ, Gentile JM, Edwards KL, Erickson HH, et al. Exercise-induced pulmonary haemorrhage during submaximal exercise. Equine Vet J Suppl 2006; (36):502-7.

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  2. Diagnosis of Swimming Induced Pulmonary Edema—A Review vol.8, pp.None, 2015, https://doi.org/10.3389/fphys.2017.00652