Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Predictors of Relapse in Patients with Organizing Pneumonia

  • Kim, Minjung (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Cha, Seung-Ick (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Seo, Hyewon (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Shin, Kyung-Min (Department of Radiology, Kyungpook National University School of Medicine) ;
  • Lim, Jae-Kwang (Department of Radiology, Kyungpook National University School of Medicine) ;
  • Kim, Hyera (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Yoo, Seung-Soo (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Lee, Jaehee (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Lee, Shin-Yup (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Kim, Chang-Ho (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Park, Jae-Yong (Department of Internal Medicine, Kyungpook National University School of Medicine)
  • Received : 2014.09.01
  • Accepted : 2015.04.09
  • Published : 2015.04.30
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Abstract

Background: Although organizing pneumonia (OP) responds well to corticosteroid therapy, relapse is common during dose reduction or follow-up. Predictors of relapse in OP patients remain to be established. The aim of the present study was to identify factors related to relapse in OP patients. Methods: This study was retrospectively performed in a tertiary referral center. Of 66 OP patients who were improved with or without treatment, 20 (30%) experienced relapse. The clinical and radiologic parameters in the relapse patient group (n=20) were compared to that in the non-relapse group (n=46). Results: Multivariate analysis demonstrated that percent predicted forced vital capacity (FVC), $PaO_2/FiO_2$, and serum protein level were significant predictors of relapse in OP patients (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.70-0.97; p=0.018; OR, 1.02; 95% CI, 1.00-1.04; p=0.042; and OR, 0.06; 95% CI, 0.01-0.87; p=0.039, respectively). Conclusion: This study shows that FVC, $PaO_2/FiO_2$ and serum protein level at presentation can significantly predict relapse in OP patients.

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References

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