Tuberculosis and Respiratory Diseases

  • 제78권3호
  • /
  • Pages.156-160
  • /
  • 2015
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  • 1738-3536(pISSN)
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  • 2005-6184(eISSN)
대한결핵및호흡기학회 (The Korean Academy of Tuberculosis and Respiratory Diseases)
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Update of Sepsis: Recent Evidences about Early Goal Directed Therapy

  • Cho, Woo Hyun (Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine)
  • 투고 : 2015.01.24
  • 심사 : 2015.02.23
  • 발행 : 2015.04.30
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초록

Severe sepsis and septic shock is a life-threatening disease. It is combined with multi-organ failure. In the past decade, early goal directed therapy has been proposed as an effective treatment strategy for better outcome. Recent epidemiologic studies showed that the outcome of sepsis has been improved with the introduction of early goal directed therapy. However, it is unclear which elements of early goal directed therapy contributed to the better outcome. Recent prospective and randomized trials suggested that some elements of early goal directed therapy did not have any effect on the outcome benefit. In this paper, recent articles about early goal directed therapy will be reviewed and the effectiveness of individual elements of early goal directed therapy will be discussed.

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참고문헌

  1. Elixhauser A, Friedman B, Stranges E. Septicemia in U.S. hospitals, 2009: statistical brief #122. Healthcare Cost and Utilization Project (HCUP) statistical briefs. Rockville: Agency for Health Care Policy and Research; 2006.
  2. Sasse KC, Nauenberg E, Long A, Anton B, Tucker HJ, Hu TW. Long-term survival after intensive care unit admission with sepsis. Crit Care Med 1995;23:1040-7. https://doi.org/10.1097/00003246-199506000-00008
  3. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-77. https://doi.org/10.1056/NEJMoa010307
  4. ARISE Investigators; ANZICS Clinical Trials Group, Peake SL, Delaney A, Bailey M, Bellomo R, et al. Goal-directed resuscitation for patients with early septic shock. N Engl J Med 2014;371:1496-506. https://doi.org/10.1056/NEJMoa1404380
  5. ProCESS Investigators, Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, et al. A randomized trial of protocolbased care for early septic shock. N Engl J Med 2014;370:1683-93. https://doi.org/10.1056/NEJMoa1401602
  6. Phua J, Koh Y, Du B, Tang YQ, Divatia JV, Tan CC, et al. Management of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study. BMJ 2011;342:d3245. https://doi.org/10.1136/bmj.d3245
  7. Lagu T, Rothberg MB, Shieh MS, Pekow PS, Steingrub JS, Lindenauer PK. Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007. Crit Care Med 2012;40:754-61. https://doi.org/10.1097/CCM.0b013e318232db65
  8. Miller RR 3rd, Dong L, Nelson NC, Brown SM, Kuttler KG, Probst DR, et al. Multicenter implementation of a severe sepsis and septic shock treatment bundle. Am J Respir Crit Care Med 2013;188:77-82. https://doi.org/10.1164/rccm.201212-2199OC
  9. Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA 2014;311:1308-16. https://doi.org/10.1001/jama.2014.2637
  10. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013;41:580-637. https://doi.org/10.1097/CCM.0b013e31827e83af
  11. Blanco J, Muriel-Bombin A, Sagredo V, Taboada F, Gandia F, Tamayo L, et al. Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. Crit Care 2008;12:R158. https://doi.org/10.1186/cc7157
  12. Danai P, Martin GS. Epidemiology of sepsis: recent advances. Curr Infect Dis Rep 2005;7:329-34. https://doi.org/10.1007/s11908-005-0005-1
  13. Esper AM, Martin GS. Extending international sepsis epidemiology: the impact of organ dysfunction. Crit Care 2009;13:120. https://doi.org/10.1186/cc7704
  14. Harrison DA, Welch CA, Eddleston JM. The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database. Crit Care 2006;10:R42. https://doi.org/10.1186/cc4854
  15. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003;348:1546-54. https://doi.org/10.1056/NEJMoa022139
  16. Zimmerman JE, Kramer AA, Knaus WA. Changes in hospital mortality for United States intensive care unit admissions from 1988 to 2012. Crit Care 2013;17:R81. https://doi.org/10.1186/cc12695
  17. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296-327. https://doi.org/10.1097/01.CCM.0000298158.12101.41
  18. Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004;32:858-73. https://doi.org/10.1097/01.CCM.0000117317.18092.E4
  19. Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R, et al. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 2004;350:2247-56. https://doi.org/10.1056/NEJMoa040232
  20. SAFE Study Investigators, Finfer S, McEvoy S, Bellomo R, McArthur C, Myburgh J, et al. Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis. Intensive Care Med 2011;37:86-96. https://doi.org/10.1007/s00134-010-2039-6
  21. Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M, et al. Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med 2014;370:1412-21. https://doi.org/10.1056/NEJMoa1305727
  22. Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Aneman A, et al. Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. N Engl J Med 2012;367:124-34. https://doi.org/10.1056/NEJMoa1204242
  23. LeDoux D, Astiz ME, Carpati CM, Rackow EC. Effects of perfusion pressure on tissue perfusion in septic shock. Crit Care Med 2000;28:2729-32. https://doi.org/10.1097/00003246-200008000-00007
  24. Bourgoin A, Leone M, Delmas A, Garnier F, Albanese J, Martin C. Increasing mean arterial pressure in patients with septic shock: effects on oxygen variables and renal function. Crit Care Med 2005;33:780-6. https://doi.org/10.1097/01.CCM.0000157788.20591.23
  25. Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N, et al. High versus low blood-pressure target in patients with septic shock. N Engl J Med 2014;370:1583-93. https://doi.org/10.1056/NEJMoa1312173
  26. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA, et al. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 2010;303:739-46. https://doi.org/10.1001/jama.2010.158
  27. Puskarich MA, Trzeciak S, Shapiro NI, Albers AB, Heffner AC, Kline JA, et al. Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest 2013;143:1548-53. https://doi.org/10.1378/chest.12-0878
  28. Forsythe SM, Schmidt GA. Sodium bicarbonate for the treatment of lactic acidosis. Chest 2000;117:260-7. https://doi.org/10.1378/chest.117.1.260
  29. De Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, et al. Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med 2010;362:779-89. https://doi.org/10.1056/NEJMoa0907118
  30. De Backer D, Aldecoa C, Njimi H, Vincent JL. Dopamine versus norepinephrine in the treatment of septic shock: a metaanalysis. Crit Care Med 2012;40:725-30. https://doi.org/10.1097/CCM.0b013e31823778ee
  31. Hayes MA, Timmins AC, Yau EH, Palazzo M, Hinds CJ, Watson D. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 1994;330:1717-22. https://doi.org/10.1056/NEJM199406163302404
  32. Gattinoni L, Brazzi L, Pelosi P, Latini R, Tognoni G, Pesenti A, et al. A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. N Engl J Med 1995;333:1025-32. https://doi.org/10.1056/NEJM199510193331601
  33. Holst LB, Haase N, Wetterslev J, Wernerman J, Guttormsen AB, Karlsson S, et al. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med 2014;371:1381-91. https://doi.org/10.1056/NEJMoa1406617

피인용 문헌

  1. 요로감염과 관련된 중증 패혈증 및 패혈성 쇼크의 치료 vol.17, pp.3, 2015, https://doi.org/10.22730/jmls.2020.17.3.80